The main topic of the study is to evaluate the effect of particle concentration and fractional composition on the differential pressure in the Venturi tube during the measurement of flow rate of the gasparticle mixture. Gas phase flow was described by Euler method, while particles movement by Lagrange method. Calculations were performed using ANSYS Fluent Package. A series of numerical calculations were carried out on the particle loading ratio Y ≤ 2 and their diameters of 10 µm ≤ d p ≤ 200 µm. It has been found that, except for the Y concentration loading ratio, the increase in the differential pressure in the venturi tube also affects the Stokes number. It depends on the flow conditions and particles diameter. A correction function has been proposed to determine the effect of particles diameter on the results of the mixture flow measurement. The results of the calculations were compared with the Lee and Crowe experimental data. A good comparison of calculation results to measurement results was found.