Thermodynamic Properties of the First-Generation Hybrid Dendrimer with “Carbosilane Core/Phenylene Shell” Structure

Abstract

The molar heat capacity of the first-generation hybrid dendrimer with a “carbosilane core/phenylene shell” structure was measured for the first time in the temperature range T = 6–600 K using a precise adiabatic vacuum calorimeter and DSC. In the above temperature interval, the glass transition of the studied compound was observed, and its thermodynamic characteristics were determined. The standard thermodynamic functions (the enthalpy, the entropy, and the Gibbs energy) of the hybrid dendrimer were calculated over the range from T = 0 to 600 K using the experimentally determined heat capacity. The standard entropy of formation of the investigated dendrimer was evaluated at T = 298.15 K. The obtained thermodynamic properties of the studied hybrid dendrimer were compared and discussed with the literature data for some of the first-generation organosilicon and pyridylphenylene dendrimers.

Integration of Hybrid Dendrimers and Their Generations for Modulated Spatio‐Temporal Action

“…Moreover, glucan conjugated dendrimers 30 (GD 30) comprising of particle size 30 nm efficiently reduces cancer metastasis upon absorption by lymph nodes at specific target site in 48 h. [71] 1. 4…”

“…Synthetic polymer, the branched structure dendrimers consist of the central domain, bifurcated layer, and conjugated functional groups at extreme ends using divergent and convergent preparation approaches. [ 1–4 ] Due to their extremely branched structures and functionalization, the desirable surface characteristics like flexibility/rigidity, monodispersibility, shape, and solubility are explored with significant encapsulation. [ 3 ] Dendrimers show potential as non‐viral, novel, and therapeutic delivery transporters owing to their high capacity and ability to improve biodistribution of variety of drugs (ibuprofen, indomethacin, fluoroquinolones, macrolides, beta‐lactamines tenofovir, maraviroc, and zidovudine), nucleic acids (oligonucleotide, small interfering RNA (siRNA), and aptamer), genetic materials (DNA, RNA, and genes), and chemical diagnostic agents (gadolinium chelates, superparamagnetic iron oxide particles, and paramagnetic metal chelates such as Gd(III)‐DOTA for imaging.…”

“…poly(glutamic acid), poly(propyleneimine) and polyester with chloro(diphenyl phosphine) gold, copper oxide, and bovine serum albumin each possessing their own extremely branching atomic configuration. [ 4 ] The hybrid dendrimers display both the features derived from dendrimer constituents as well as their own original capabilities like significant entrapment efficiency, surface area, biocompatibility, biodegradability, bioavailability, and as non‐viral agents for targeted action. Hybrid dendrimers are acquainted with a variety of particular properties including optical, mechanical, electrical, and biological aspect with the integration of inorganic fragments like silica, copper, gold, carbosilane, platinum, and zinc.…”

“…Synthetic polymer, the branched structure dendrimers consist of the central domain, bifurcated layer, and conjugated functional groups at extreme ends using divergent and convergent preparation approaches. [1][2][3][4] Due to their extremely branched structures and functionalization, the desirable surface characteristics like flexibility/rigidity, monodispersibility, shape, and solubility are explored with significant encapsulation. [3] Dendrimers show potential as non-viral, novel, and therapeutic (DNA and RNA), proteins/peptides, carbosilane, urea, silica, stem cells, guanidine, etc.…”