Thermodynamic properties of solubility of 2-methyl-5-arylfuran-3-carboxylic acids in organic solvents

Abstract

Abstract.1 The temperature dependencies of both acids solubility in acetonitrile, dimethylketone, isopropanol, ethylacetate and benzene were investigated. The results were represented by Shredder's equation according to which enthalpies, entropies and Gibbs energy of solubility at 298 K were determined. Fusion heats of the acids were determined using differential thermal analysis. In accordance with obtained values the enthalpies, entropies and Gibbs energy of mixing were calculated. The compensating effect of mixing was observed for al solvents with carboxy group.

Thermodynamic Properties of 2-Methyl-5-arylfuran-3 Carboxylic Acids Chlorine Derivatives in Organic Solvents

“…2). A similar dependence was observed in our previous studies [13] for 2-methyl-5-phenylfuran-3-carboxylic acid (Eq. (9)) and 2-methyl-5-(4-methylphenyl)-furan-3-carboxylic acid (Eq.…”

“…Since most reactions occur in solutions, the optimization of synthesis and purification of compounds with an arylfuran fragment is impossible without the determination of thermodynamic parameters of solubility. Some works regarding the thermodynamic properties of compounds with arylfuran fragment have appeared in recent years [12][13][14][15][16][17]. The presented work is the continuation of the previous research.…”

“…Δ fus H = T fus • Δ fus S (4) To evaluate the specific entropy of fusion of the investigated acids, we used the experimental results [13][14][15][16][17][18][19][20] obtained by a derivatographic method for arylfurans (Table 4).…”

“…2. Dependence between the enthalpy and the entropy of mixing for acids in organic solvents: 2-methyl-5-(2-chloro-5-trifluoromethylphenyl)-furan-3-carboxylic acid (○); 2-methyl-5-(2,5-dichlorophenyl)-furan-3-carboxylic acid (◊); 5-methyl-5-(4-methylphenyl)-furan-3-carboxylic acid [13] (□) and 5-phenyl-2-methyl-3-furancarboxylic acid [13] (Δ); points 1-4 refer to solutions of investigated compounds in acetonitrile…”

“…The temperature dependence of the solubility of the investigated acids was determined by gravimetric method, the same as in previous studies [12][13][14][15][16][17].…”