Thermodynamic properties of microemulsions: Pseudophase equilibrium—Vapor pressure measurements

Biais, J.; Ödberg, Lars; Stenius, Per

doi:10.1016/0021-9797(82)90080-7

Cited by 47 publications

(12 citation statements)

References 24 publications

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“…We note that these assumptions concerning the distribution of the components between different domains in the solution is very similar to the pseudophase model suggested by Biais et al [30,31].…”

Section: Descriptions Of the Modelmentioning

confidence: 81%

“…Both theoretical calculations and experimental data indicate that the formation of micelles for this high water/octanoate ratio starts at w(Cl0OH ) ~ 95%. That the continuous medium behaves as the corresponding pure organic solvent when saturated with water is also a result of the ,,pseudophase" treatment described in reference [30] and has also been found by spectroscopic analysis of the system water/Aerosol OT/isooctane [33]. Calorimetric and dielectric studies also indicate that aggreagations begins at w(C10OH ) ~ 95% [27,32].…”

Section: Discussionmentioning

confidence: 92%

“…This leads to variations in the solubility of water and, hence, it is necessary to take into account the distribution of water between the interior of the reversed micelle and the organic phase. The importance of the autoassociation process caused by intramolecular hydrogen bonding in alcohol-containing solvents as well as the distribution of water between the aqueous and organic moieties in reversed micellar solutions is clearly brought forward in a recent thermodynamic model [30,31].…”

Section: Introductionmentioning

confidence: 99%

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Reversed micellar solutions in the system sodium octanoate/decanol/water: Model calculations and dynamic light scattering measurements

Sjöblom¹,

Rosenqvist²,

Stenius³

1982

Colloid & Polymer Sci

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Geometrical calculations of aggregate sizes in the reversed micellar solution phase of the system water/sodium octanoate/decanol at 20 ~ have been tested by dynamic light scattering studies. The autocorrelation functions were interpreted in the simplest possible way (monodisperse aggregates, Stokes-Einstein diffusion equations) since the geometrical model does not account for detailed changes in shapes or micellar interactions. The model predicts the main features of micellization in these solutions, i. e., the micelles grow continuously as the concentration of water or the molar ratio water/octanoate increases, association begins at quite low concentrations of water and the surrounding decanolic solvent behaves as pure decanol which is saturated with water.

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Section: Descriptions Of the Modelmentioning

confidence: 81%

Section: Discussionmentioning

confidence: 92%

Section: Introductionmentioning

confidence: 99%

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Reversed micellar solutions in the system sodium octanoate/decanol/water: Model calculations and dynamic light scattering measurements

Sjöblom¹,

Rosenqvist²,

Stenius³

1982

Colloid & Polymer Sci

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“…In an ionic microemulsion, containing surfactant, alcohol, water and hydrocarbon, the pseudophases are the hydrophobic domains, the hydrophilic domains and the interfacial region. Vapour pressure measurements have been quite successful in elucidating the composition of the pseudophases, by comparison with reference systems [25,26]. Such an approach, in this case assuming that a pseudophase model is applicable and that the compositions of the domains can be obtained from vapour pressures, was made for the present system.…”

Section: Discussionmentioning

confidence: 98%

An NMR self-diffusion investigation of water/xylene/alkyl amine solutions

Wärnheim

1986

Colloid & Polymer Sci

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Extensions of the solution phases have been determined and the self-diffusion behaviour investigated in ternary systems containing water/xylene/primary alkyl amine, where the chain length of the amine varied between C6 and C_q 0. The phase diagrams at 25~ are dominated by a solution phase and a rather large water/xylene miscibility gap which increases slightly in size with increasing chain length of the amine. A lamellar liquid crystalline phase was found in all binary amine/water systems at 25 ~ except for hexylamine where the lamellar phase melts below this temperature. The self-diffusion coefficients of all components decrease in a similar way when water is added to a xylene/amine solution. The self-diffusion is rapid and of similar magnitude for all components, which shows that no well-defined inverse aggregates are formed. The data are discussed in terms of hydrogen bonding between the different species in the solution.

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“…These studies included exposure of formulation to thermal (both low & high) as well as mechanical stress & observing the effects on the phase separation, clarity of the ME formulation (Moulik et al, 2000;Biais et al, 1982) .The test was carried out in two parts;…”

Section: Thermodynamic Stability Studiesmentioning

confidence: 99%

Formulation and Evaluation of Microemulsion Based in Situ Gel of Acyclovir for Vaginal Delivery

Deshkar

Bokare

Todmal

2020

ijrps

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The purpose of the present study was to formulate and evaluate microemulsion based in situ gel of Acyclovir (ACV) for the vaginal delivery. The solubility of ACV in oils and surfactants and co-surfactant was evaluated to identify the components of the microemulsion. Microemulsion region was determined by using the pseudo-ternary phase diagrams for different formulations. Microemulsion formulation was prepared using Labrafil M1994C as oil phase, Cremophor RH40 as surfactant and Polyethylene glycol 400 and Transcutol P as co-surfactant and water. Microemulsion formulations were evaluated for pH, viscosity, conductivity and stability study. In situ gel of ACV, microemulsion was prepared using thermosensitive polymer, poloxamer.In situ gelwas characterized for viscosity, gelling temperature, the effect of dilution on gelling temperature, gelling ability, and in vitro drug release and release kinetics. The globule size of developed microemulsion was less than 100 nm with PDI in the range 0.307 to 0.641. The optimized microemulsion based in situ gel demonstrated shear thinning behaviour, the gelation temperature with and without dilution was in the range of 30-35ºC, and the drug release was sustained over eight hours. Mucoadhesive properties of microemulsion based in situ gel formulations were determined with a texture analyzer using a goat vaginal tissue, and the results indicated that the presence of microemulsion increased the mucoadhesion significantly. Microemulsion based in situ gel was successfully developed for vaginal delivery of Acyclovir.

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Thermodynamic properties of microemulsions: Pseudophase equilibrium—Vapor pressure measurements

Cited by 47 publications

References 24 publications

Reversed micellar solutions in the system sodium octanoate/decanol/water: Model calculations and dynamic light scattering measurements

Reversed micellar solutions in the system sodium octanoate/decanol/water: Model calculations and dynamic light scattering measurements

An NMR self-diffusion investigation of water/xylene/alkyl amine solutions

Formulation and Evaluation of Microemulsion Based in Situ Gel of Acyclovir for Vaginal Delivery

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