Thermodynamic properties of aqueous solutions of macromolecular compounds

Masimov, A.A.; Zaslavsky, Boris Y.; Gasanov, A.A.; Рогожин, С. В.

doi:10.1016/s0021-9673(01)87838-9

Cited by 7 publications

(6 citation statements)

References 8 publications

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“…Results of the analysis of Collander linear relationships between distribution coefficients of drugs in all different octanol-buffer systems examined are presented in Table S1. Sixteen compounds (# 2, 5, 6,9,10,12,13,15,17,18,20,21,22,24,25,27) deviate from the relationship by more than 25% and are considered to behave as outliers, Sixteen compounds (# 2, 5, 6,9,10,12,13,15,17,18,20,21,22,24,25,27) deviate from the relationship by more than 25% and are considered to behave as outliers,…”

Section: Resultsmentioning

confidence: 99%

“…where superscripts i and o denote the two octanol-buffer i and octanol-buffer o systems under comparison. It follows from eqn (9) and eqn (2) that the slope in the Collander relationship can be expressed as:…”

Section: Resultsmentioning

confidence: 99%

“…The ionic composition of an aqueous phase in an octanol-buffer system affects the solute partitioning in the system [8][9][10] , but very limited studies of salt and buffer effects have been reported in the literature to our knowledge [11][12][13][14] . The ionic composition of an aqueous phase in an octanol-buffer system affects the solute partitioning in the system [8][9][10] , but very limited studies of salt and buffer effects have been reported in the literature to our knowledge [11][12][13][14] .…”

Section: Introductionmentioning

confidence: 99%

“…The likely answer seems to be that different authors might use different buffers in the octanol-buffer systems, and only the pH value used is commonly reported in the literature. The ionic composition of an aqueous phase in an octanol-buffer system affects the solute partitioning in the system, [8][9][10] but very limited studies of the salt and buffer effects have been reported. [11][12][13][14] This study examined and compared the effects of the salt composition on the partitioning of randomly selected drugs in octanol-buffer systems.…”

Section: Introductionmentioning

confidence: 99%

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Effect of ionic composition on the partitioning of organic compounds in octanol–buffer systems

et al. 2015

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Distribution of 29 drug compounds was examined in octanol-buffer systems of eight different ionic compositions at pH 7.4. It was found that the ionic composition of the octanol-buffer system has a noticeable and unpredictable effect on the logD 7.4 values for different compounds. It is established that the response of compounds to different ionic environments displayed as logD 7.4 values are linearly interrelated similarly to different properties of compounds in the organic solvent-free aqueous solutions reported previously [Ferreira et al., Phys. Chem. Chem. Phys. 2014, 16, 23347]. Analysis of the role of different structural features of compounds examined in their ionic responsiveness showed that molecular polarizability and polar surface area are the two most important features. It is suggested that the relationships reported here and previously are based on the same physical principles that must be taken into account in any theoretical model of solute-water interactions in aqueous solutions containing salt additives.

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Section: Resultsmentioning

confidence: 99%

Section: Resultsmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Effect of ionic composition on the partitioning of organic compounds in octanol–buffer systems

et al. 2015

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“…The effects of salts on the intrinsic viscosity, cloud point, swelling and solubility of various nonionic polymers in aqueous media have been reported in the literature [10][11][12]. It is known that the structure and/or thermodynamic state of water is affected by the presence of macromolecules [13][14][15] as well as by that of inorganic salts [9,16]. The observed effects of both anions and cations upon the Dextran-PVA biphasic system seems to disagree with the direct ion-polymer binding hypothesis.…”

Section: Discussionmentioning

confidence: 99%

Aqueous biphasic systems formed by nonionic polymers I. Effects of inorganic salts on phase separation

Zaslavsky

Bagirov²,

Borovskaya

et al. 1986

Colloid & Polymer Sci

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The effect of salts KSCN, KI, KBr, KCI, KC104, KF, K2SO4 and NH4CI, LiC1, NaC1, KC1, CsC1 on the binodials of the phase diagrams for aqueous biphasic dextranpolyvinylpyrrolidone, dextran-polyvinyl alcohol, dextran-ficoll and dextran-polyethylene glycol systems was studied. It is established that the K-salts present at the concentrations of 0.1 and 0.5 mol/kg alter the binodials of the phase diagrams for the above systems. The effect of a salt is found to be related to the lyotropy of the salt quantified by the salt molal surface tension increment. It is assumed that phase separation in an aqueous polymer biphasic system is affected by the presence of a salt mainly due to the effect of the salt on the structure and/or state of water in the system.

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Methods of analysis of the relative hydrophobicity of biological solutes

Zaslavsky

Масимов²

Topics in Current Chemistry

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Thermodynamic properties of aqueous solutions of macromolecular compounds

Cited by 7 publications

References 8 publications

Effect of ionic composition on the partitioning of organic compounds in octanol–buffer systems

Effect of ionic composition on the partitioning of organic compounds in octanol–buffer systems

Aqueous biphasic systems formed by nonionic polymers I. Effects of inorganic salts on phase separation

Methods of analysis of the relative hydrophobicity of biological solutes

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