Abstract:<p>Threofuranosyl nucleic
acid (TNA) is an analogue of DNA. Its inter-nucleotide linkages are shifted
from the wild-type 5'-to-3' one to the 3'-to-2' one. As a result, the number of
covalent bonds between consecutive phosphates is reduced from 6 to 5. This
leads to higher chemical stability, less reactive groups, and lower
conformational flexibility. Experimental observations indicate that the
interaction network is perturbed at the minimal level and the thermodynamic
stability of the duplex is u… Show more
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