Thermodynamic behaviour of an e-cigarette: Investigation of nicotine delivery consistency using nicotine yield

Soulet, Sébastien; Casile, Carine

doi:10.1016/j.tsep.2022.101452

Cited by 2 publications

(1 citation statement)

References 33 publications

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“…This exponential behavior in reaction rates, also found in articles on CO, is fundamentally linked to Arrhenius relations and reveals a significant temperature increase above the temperatures of optimal conditions. In an optimal regime, e-liquid vaporization occurs under thermal equilibrium or close to it [50]. Therefore, above these equilibrium conditions, e-liquids are overheated in the gas phase by radiative heat transfers.…”

Section: Foreword: the Optimal Regime Of Vapingmentioning

confidence: 99%

Critical Review of the Recent Literature on Organic Byproducts in E-Cigarette Aerosol Emissions

Soulet

Sussman

2022

Toxics

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We review the literature on laboratory studies quantifying the production of potentially toxic organic byproducts (carbonyls, carbon monoxide, free radicals and some nontargeted compounds) in e-cigarette (EC) aerosol emissions, focusing on the consistency between their experimental design and a realistic usage of the devices, as determined by the power ranges of an optimal regime fulfilling a thermodynamically efficient process of aerosol generation that avoids overheating and “dry puffs”. The majority of the reviewed studies failed in various degrees to comply with this consistency criterion or supplied insufficient information to verify it. Consequently, most of the experimental outcomes and risk assessments are either partially or totally unreliable and/or of various degrees of questionable relevance to end users. Studies testing the devices under reasonable approximation to realistic conditions detected levels of all organic byproducts that are either negligible or orders of magnitude lower than in tobacco smoke. Our review reinforces the pressing need to update and improve current laboratory standards by an appropriate selection of testing parameters and the logistical incorporation of end users in the experimental design.

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Section: Foreword: the Optimal Regime Of Vapingmentioning

confidence: 99%

Critical Review of the Recent Literature on Organic Byproducts in E-Cigarette Aerosol Emissions

Soulet

Sussman

2022

Toxics

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Physical and chemical characterizations of a reference e-cigarette used in animal testing

Soulet,

Constans,

Quinty

2023

Sci Rep

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A minimal necessary condition for preclinical studies to contribute to risk assessments of e-cigarettes (ECs) is the ability to expose laboratory animals to an appropriate dosage of aerosols. In this study, we examined the fulfilment of this essential consistency condition for the ECX-Joyetech E-Vic Mini (ECX), a piece of computerized exposure equipment manufactured by SCIREQ, which has been employed by numerous in vivo testing. We began by calibrating the customary Evic VTC mini device mod and the 4 coils available, reproducing in the laboratory the operation of the ECX in the power-control and temperature-control modes, using puffing parameters recommended by its documentation. We then conducted the following tests for each coil: (1) verifying whether the generated aerosols satisfy an optimal operational regime, free from overheating, as determined by a linear relation between the mass of vaporized e-liquid vs. supplied power and (2) obtaining the mean yields of aldehydes for each of the tested power settings and coils. The results of these tests show that, under the main conditions used in in vivo testing, the ECX equipment fails to comply with these consistency requirements, especially for coils with low subohm resistance, a shortcoming that can be corrected by applying much larger airflows for these coils. Therefore, the outcomes of preclinical studies using the ECX equipment should be examined with great scepticism and subjected to further testing.

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Thermodynamic behaviour of an e-cigarette: Investigation of nicotine delivery consistency using nicotine yield

Cited by 2 publications

References 33 publications

Critical Review of the Recent Literature on Organic Byproducts in E-Cigarette Aerosol Emissions

Critical Review of the Recent Literature on Organic Byproducts in E-Cigarette Aerosol Emissions

Physical and chemical characterizations of a reference e-cigarette used in animal testing

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