Thermodynamic and spectroscopic study of copper(<scp>II</scp>)–glycyl-<scp>L</scp>-histidylglycine complexes in aqueous solution

Daniele, Pier Giuseppe; Zerbinati, Orfeo; Zelano, Vincenzo; Ostacoli, Giorgio

doi:10.1039/dt9910002711

Cited by 57 publications

(40 citation statements)

References 15 publications

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“…The amide may form the Cu(Imip)(L) complex by coordination through the amine and carbonyl groups. It was reported that on increasing the pH, the coordination sites should switch from carbonyl oxygen to amide nitrogen [37,38]. However, since the stability constant value of the 111-1 species is in fair agreement with those of amino acids, where there is no induce ionization.…”

Section: Amide Complexesmentioning

confidence: 80%

Complex formation equilibria of imipenem with some transition metal ions. Ternary complex formation reactions involving Cu(II) with imipenem and various bio-relevant ligands

Shoukry

2013

Eur. J. Chem.

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KEYWORDSImipenem is one of the β-lactam antibiotics (β-lactamase inhibitors), which are reported to be the most important class of drugs that are capable of inhibiting the bacterial enzyme to protect the β-lactam antibiotic from destruction. In view of the biological importance of imipenem as drug, the ligation behavior of imipenem is studied in order to get an idea about its potentiality towards some transition metals in in-vitro systems. The binary complex formation equilibria with the metal ions Cu(II), Ni(II), Co(II), Mn(II), and Zn(II) were investigated potentiometrically. The effects of dioxane as a solvent, on the protonation constant of imipenem and the formation constants of Cu(II)-imipenem complexes were discussed. The ternary copper(II) complexes involving imipenem and various biologically relevant ligands containing different functional groups, as amino acids, amides, dicarboxylic acids and DNA constituents were investigated. The stability constants of the complexes are determined. The mechanisms of complex formation are speculatively discussed based on the calculated stability constant values. The ternary complexes are formed by simultaneous reactions. The concentration distributions of various species formed in solution were also evaluated as a function of pH.

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Section: Amide Complexesmentioning

confidence: 80%

Complex formation equilibria of imipenem with some transition metal ions. Ternary complex formation reactions involving Cu(II) with imipenem and various bio-relevant ligands

Shoukry

2013

Eur. J. Chem.

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“…Using a suitable computer program 22 the data were fitted to the final equation for estimating the formation constant of equation 3. We used the Gauss-Newton nonlinear least-squares method in computer program to refine the absorbance by minimizing the error squares sum from equation 8 2 ) ( 1, 2, 3, ...) (10) where a i is a quasi-experimental and b i is a calculated one. The computer program consisted of two different kind of fitting, (A) graphical, (B) numerical.…”

Section: Resultsmentioning

confidence: 99%

“…6 Transition metal complexes of amino acids and peptides in aqueous solution were studied by various techniques. [6][7][8][9][10][11][12][13][14][15][16][17][18][19][20] Potentiometry and UV-Vis spectrophotometry are the most widely used methods in the investigation of metal-peptide complexes. 6 Many analytical methods use molecular absorption spectrophotometry of coordination compounds for the determination of metal ions in solution.…”

Section: Introductionmentioning

confidence: 99%

Complexes of thallium(I) and cadmium(II) with dipeptides of L-phenylalanylglycine and Glycyl-L-phenylalanine

Sharifi¹,

Nori‐Shargh²,

Bahadory³

2007

J. Braz. Chem. Soc.

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As constantes de estabilidade dos complexos de íons tálio(I) e cádmio(II) com dipeptídeos de glicil-L-fenilalanina e L-fenilalanilglicina foram determinadas em solução aquosa a 25 °C e meio iônico 0,1 mol dm -3 usando uma combinação de técnicas potenciométricas e espectrofotométricas. Perclorato de sódio foi usado para manter a força iônica. A composição dos complexos formados foi determinada e observou-se que tálio (I) The stability constants of the complexes of thallium(I) and cadmium(II) ions with dipeptides of glycyl-L-phenylalanine and L-phenylalanylglycine were determined in aqueous solution at 25 °C and 0.1 mol dm -3 ionic medium using a combination of potentiometric and spectrophotometric techniques. Sodium perchlorate was used to maintain the ionic strength. The composition of the formed complexes was determined and it was shown that thallium(I) and cadmium (

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“…On increasing the pH, the coordination sites should switch from the carbonyl oxygen to the amide nitrogen. Such a change in coordination centers is now well documented [21,22]. The amide groups undergo deprotonation and the [Cu(PA)(LH −1 )] complexes are formed.…”

Section: Ternary Complex Formation Equilibria Involving Amino Acids Amentioning

confidence: 96%

Complex Formation Equilibria of Ternary Complexes of Cu(II) Involving Pyridine-2-Carboxylic Acid and Various Biologically Relevant Ligands

Shoukry¹,

Hosny²,

Amin³

et al. 2016

Int. J. Curr. Res. Chem. Pharm. Sci

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Binary and ternary complexes of Cu 2+ involving pyridine-2-carboxylic acid (picolinic acid; PA) and amino acids, peptides or DNA constituents(HL) have been investigated. Ternary complexes of amino acids or peptides are formed by simultaneous reactions. Amino acids form the [Cu(PA)L] complex, whereas peptides form [Cu(PA)L] and [Cu(PA)(LH -1 )]. The ternary complexes of Cu 2+ with picolinic acid and DNA are formed in a stepwise process, whereby binding of Cu 2+ to picolinic acid is followed by ligation of the DNA constituents. The stability of the ternary complexes is compared with the stabilities of the corresponding binary complexes. DNA constituents form both 1:1 and 1:2 complexes with[Cu(PA)] + . The concentration distribution of the complexes in solution was evaluated. Probable mode of chelation with picolinic acid and various biologically relevant ligands was discussed. Absorption spectra of the binary and ternary complexes of Cu 2+ were also investigated. The isolated metal chelates, [Cu(PA)(Cl2)(H2O)2] and [Cu(PA)2(Cl2)], are characterized by elemental analysis and infrared measurements.

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Thermodynamic and spectroscopic study of copper(II)–glycyl-L-histidylglycine complexes in aqueous solution

Cited by 57 publications

References 15 publications

Complex formation equilibria of imipenem with some transition metal ions. Ternary complex formation reactions involving Cu(II) with imipenem and various bio-relevant ligands

Complex formation equilibria of imipenem with some transition metal ions. Ternary complex formation reactions involving Cu(II) with imipenem and various bio-relevant ligands

Complexes of thallium(I) and cadmium(II) with dipeptides of L-phenylalanylglycine and Glycyl-L-phenylalanine

Complex Formation Equilibria of Ternary Complexes of Cu(II) Involving Pyridine-2-Carboxylic Acid and Various Biologically Relevant Ligands

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