2003
DOI: 10.1136/bjo.87.1.90
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Thermochemotherapy in hereditary retinoblastoma

Abstract: Br J Ophthalmol 2003;87:90-95 Background/aim: The combination of chemotherapy and transpupillary thermotherapy, thermochemotherapy (TCT) has become an established part of the treatment plan in advanced retinoblastoma. The aim of this study was to identify safe indications, the complications as well as the limitations of this new treatment for retinoblastoma. Methods: Tumour response and side effects of TCT with an indirect laser ophthalmoscope (spot size about 400 µm) in 55 tumours of 26 children with bilat… Show more

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Cited by 61 publications
(25 citation statements)
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“…1,2 Numerous conservative treatment modalities have been published: cryoapplication, thermotherapy alone or combined with systemic chemotherapy, plaque radiotherapy, or even exclusive chemotherapy. [3][4][5][6][7][8][9][10][11][12] More recently, periocular, intraarterial, and intravitreal administration of chemotherapy have been used and are still under evaluation. These last modalities were developed during the study period.…”
Section: Introductionmentioning
confidence: 99%
“…1,2 Numerous conservative treatment modalities have been published: cryoapplication, thermotherapy alone or combined with systemic chemotherapy, plaque radiotherapy, or even exclusive chemotherapy. [3][4][5][6][7][8][9][10][11][12] More recently, periocular, intraarterial, and intravitreal administration of chemotherapy have been used and are still under evaluation. These last modalities were developed during the study period.…”
Section: Introductionmentioning
confidence: 99%
“…Brachytherapy was the primary treatment in 6 tumours. In 7 eyes, brachytherapy was used as secondary treatment for recurrences following combined treatment with laser coagulation (n = 5), cryocoagulation (n = 3) or thermochemotherapy (n = 3) [12] . Demographic data of the treated tumours and of the therapy parameters are listed in table 1 .…”
Section: Resultsmentioning
confidence: 99%
“…The infrared laser is focused directly on the tumor surface using either an ophthalmic microscope adapter or a large spot size indirect ophthalmoscope adapter. When using the indirect ophthalmoscope for TTT, it is important to ensure that the correct adapter is being used, as adapters designed for diode photocoagulation will not provide a continuous wavelength delivery necessary for hyperthermia (Lumbroso et al 2003;Schueler et al 2003).…”
Section: Focal Therapiesmentioning
confidence: 99%