Thermochemotherapy for B16 Melanoma: Combination Therapy of Hyperthermia, Melphalan, and CCNU in Mice

Vicente, Vicente; Gómez, M.A.; Ochotorena, M. M.; Cremades, Adolfo Díaz-Bautista; Canteras, Manuel

doi:10.1111/j.1600-0749.1990.tb00254.x

Cited by 6 publications

(2 citation statements)

References 14 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…However, prolongation of survival time was not mentioned. Vicente et al [20] conducted experiments using whole body hyperthermia on C57 BL mice and B16 melanoma and concluded that thermochemotherapy was effective in delaying tumor growth or reducing the number of metastases, but prolongation of survival was not discussed.…”

Section: Discussionmentioning

confidence: 99%

Continuous hyperthermic peritoneal perfusion with cisplatin in mice with peritoneal dissemination of B16 melanoma

Okuyama

Endo

Maehara

et al. 1994

Seminars in Surgical Oncology

View full text Add to dashboard Cite

We designed a model of peritoneal dissemination of gastric cancer in mice. B16 melanoma cells were injected into the peritoneal cavity of C57 BL mice, the object being to search for an effective treatment for peritoneal dissemination, using hyperthermia combined with cisplatin. Following the intraperitoneal administration of tumor cells, each mouse was subjected to continuous hyperthermic peritoneal perfusion (CHPP) using the peritoneal cavity expander (PCE), with or without cisplatin in the perfusate under conditions of laparotomy. Effects of the therapy were evaluated, based on comparison of survival time between the control and treated groups. There was no prolongation of mean survival periods for the groups given CHPP, with or without cisplatin, compared to findings in the no treatment control group. Optimal timing and doses of hyperthermia and cisplatin, or adding biochemical modulators to enhance the effects of cisplatin, will need to be determined to increase the efficacy of CHPP, with or without the concomitant administration of cisplatin.

show abstract

Section: Discussionmentioning

confidence: 99%

Continuous hyperthermic peritoneal perfusion with cisplatin in mice with peritoneal dissemination of B16 melanoma

Okuyama

Endo

Maehara

et al. 1994

Seminars in Surgical Oncology

View full text Add to dashboard Cite

show abstract

“…Raaphorst and Azzam [35] reported the response of transformed and normal cell lines to antimelanin compounds, 2-and 4-hydroxyanisole, alone or combined with hyperthermia or radiation. Treatment of B 16F to melanoma with the combination of hyperthermia, melphalan, and CCNU resulted in progressive delay in tumor growth, reduced metastases, and diminution of proliferative capacity [36]. As antitumor drugs fail to discriminate between normal and target tissues, any approach enabling a chemotherapeutic agent to reach its target in a selective manner would represent a major advancement in cancer chemotherapy.…”

mentioning

confidence: 99%

Enhanced Antitumor Effect of Radiation in Combination with Heat-Sensitive Liposome-Encapsulated Drug and Hyperthermia on Murine Tumors.

Tamiz

Ralhan

1995

J. Clin. Biochem. Nutr.

View full text Add to dashboard Cite

SummaryAdjuvant hyperthermia enhances the response of melanoma to irradiation or antineoplastic drugs. Radiation in combination with a targeted drug delivery system combining a thermosensitive Liposome-encapsulated antitumor drug with hyperthermia may thus result in enhancement of therapeutic efficacy for more effective management of melanoma. The present study was based on this rationale. The therapeutic effect of radiation alone, or in combination with thermosensitive liposome-encapsulated melphalan and hyperthermia, was determined on B16F10 murine melanoma transplanted into C57B1/6 mice. This multimodality regimen resulted in marked enhancement of the antitumor efficacy in treated animals, as determined by significant tumor growth regression (p < 0.001) and prolongation of survival, compared with the level of enhancement seen in animals receiving single-modality treatment. The results suggest that radiothermochemotherapy using radiation in combination with heat-mediated selective delivery of liposomal melphalan to tumor tissue would result in more effective management of melanoma.

show abstract

Interaction of Heat and Drugs In Vitro and In Vivo

Dahl

1995

Medical Radiology

View full text Add to dashboard Cite

Thermochemotherapy for B16 Melanoma: Combination Therapy of Hyperthermia, Melphalan, and CCNU in Mice

Cited by 6 publications

References 14 publications

Continuous hyperthermic peritoneal perfusion with cisplatin in mice with peritoneal dissemination of B16 melanoma

Continuous hyperthermic peritoneal perfusion with cisplatin in mice with peritoneal dissemination of B16 melanoma

Enhanced Antitumor Effect of Radiation in Combination with Heat-Sensitive Liposome-Encapsulated Drug and Hyperthermia on Murine Tumors.

Interaction of Heat and Drugs In Vitro and In Vivo

Contact Info

Product

Resources

About