Thermochemical Properties of Dissolution of Nicotinic Acid C6H5NO2(s) in Aqueous Solution

Di, You-Ying; Xü, Dong; Kong, Yali; Zhang, Chunsheng

doi:10.1007/s10953-017-0607-x

Cited by 5 publications

(1 citation statement)

References 8 publications

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“…Nicotinic acid is missing in CHNOSZ. We used measured literature values for the thermodynamic properties at standard conditions [128,129] and imported them into CHNOSZ. This allowed to calculate the Gibbs energies of formation over the whole considered temperature range.…”

Section: Gibbs Free Energies Of Formation For Species Missing In Chnoszmentioning

confidence: 99%

Possible Ribose Synthesis in Carbonaceous Planetesimals

Paschek

Köhler

Pearce

et al. 2022

Life

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The origin of life might be sparked by the polymerization of the first RNA molecules in Darwinian ponds during wet-dry cycles. The key life-building block ribose was found in carbonaceous chondrites. Its exogenous delivery onto the Hadean Earth could be a crucial step toward the emergence of the RNA world. Here, we investigate the formation of ribose through a simplified version of the formose reaction inside carbonaceous chondrite parent bodies. Following up on our previous studies regarding nucleobases with the same coupled physico-chemical model, we calculate the abundance of ribose within planetesimals of different sizes and heating histories. We perform laboratory experiments using catalysts present in carbonaceous chondrites to infer the yield of ribose among all pentoses (5Cs) forming during the formose reaction. These laboratory yields are used to tune our theoretical model that can only predict the total abundance of 5Cs. We found that the calculated abundances of ribose were similar to the ones measured in carbonaceous chondrites. We discuss the possibilities of chemical decomposition and preservation of ribose and derived constraints on time and location in planetesimals. In conclusion, the aqueous formose reaction might produce most of the ribose in carbonaceous chondrites. Together with our previous studies on nucleobases, we found that life-building blocks of the RNA world could be synthesized inside parent bodies and later delivered onto the early Earth.

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Section: Gibbs Free Energies Of Formation For Species Missing In Chnoszmentioning

confidence: 99%

Possible Ribose Synthesis in Carbonaceous Planetesimals

Paschek

Köhler

Pearce

et al. 2022

Life

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“Cap‐Pair” Effect as the Reason of the Catalytic Properties of Nicotinic Acid: Experimental and Theoretical Studies

Nieszporek

2022

ChemPhysChem

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The influence of nicotinic acid (NC) on the kinetics and the mechanism of electroreduction of Zn2+ ions in the acetate buffer (pH=6.0) was investigated using electrochemical methods (EIS, CV, SWV and DC). It was shown that the anions of NC catalyze the electrode reaction (cap‐pair effect) by adsorbing on the surface of the mercury electrode. The catalytic activity of NC is due to its ability to form active NC−Zn2+ complexes on the electrode surface, facilitating the electron transfer process. However, no evidence of the formation of such complexes in the solution was found using classical molecular dynamics. Moreover, it was proved that the electroreduction of Zn2+ ions in the presence of NC is a two‐stage process. The first stage involves the transfer of the first electron, preceded by the partial loss of the hydration shell by the Zn2+ ions and formation of the active complex. Moreover, it was shown that in the range of lower concentrations, c≤1.10−2 mol.dm−3, the nicotinic acid shows weaker catalytic abilities than another form of vitamin B3 – nicotinamide. In the range of its higher concentrations, the nicotinic acid is a more effective catalyst for the electroreduction of Zn2+ ions.

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Prebiotic Vitamin B₃ Synthesis in Carbonaceous Planetesimals

Paschek,

Lee,

Semenov

et al. 2023

ChemPlusChem

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Aqueous chemistry within carbonaceous planetesimals is promising for synthesizing prebiotic organic matter essential to all life. Meteorites derived from these planetesimals delivered these life building blocks to the early Earth, potentially facilitating the origins of life. Here, we studied the formation of vitamin B3 as it is an important precursor of the coenzyme NAD(P)(H), which is essential for the metabolism of all life as we know it. We propose a new reaction mechanism based on known experiments in the literature that explains the synthesis of vitamin B3. It combines the sugar precursors glyceraldehyde or dihydroxyacetone with the amino acids aspartic acid or asparagine in aqueous solution without oxygen or other oxidizing agents. We performed thermochemical equilibrium calculations to test the thermodynamic favorability. The predicted vitamin B3 abundances resulting from this new pathway were compared with measured values in asteroids and meteorites. We conclude that competition for reactants and decomposition by hydrolysis are necessary to explain the prebiotic content of meteorites. In sum, our model fits well into the complex network of chemical pathways active in this environment.

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Thermochemical Properties of Dissolution of Nicotinic Acid C6H5NO2(s) in Aqueous Solution

Cited by 5 publications

References 8 publications

Possible Ribose Synthesis in Carbonaceous Planetesimals

Possible Ribose Synthesis in Carbonaceous Planetesimals

“Cap‐Pair” Effect as the Reason of the Catalytic Properties of Nicotinic Acid: Experimental and Theoretical Studies

Prebiotic Vitamin B₃ Synthesis in Carbonaceous Planetesimals

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Thermochemical Properties of Dissolution of Nicotinic Acid C6H5NO2(s) in Aqueous Solution

Cited by 5 publications

References 8 publications

Possible Ribose Synthesis in Carbonaceous Planetesimals

Possible Ribose Synthesis in Carbonaceous Planetesimals

“Cap‐Pair” Effect as the Reason of the Catalytic Properties of Nicotinic Acid: Experimental and Theoretical Studies

Prebiotic Vitamin B3 Synthesis in Carbonaceous Planetesimals

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Product

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About

Prebiotic Vitamin B₃ Synthesis in Carbonaceous Planetesimals