Thermoassociative Block Copolymers of Poly(<i>N</i>‐Isopropylacrylamide) and Poly(Propylene Oxide)

Hasan, Erol; Zhang, M.; Müller, Axel H. E.; Tsvetanov, Christo B.

doi:10.1081/ma-120030919

Cited by 29 publications

(16 citation statements)

References 34 publications

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“…The synthesis of pNIPAAM block copolymers received a significant stimulus by the development of the so-called ''living'' radical polymerization (LRP). Several pNIPAAM block copolymers have been prepared by both reversible addition-fragmentation chain transfer (RAFT) [7][8][9][10][11][12][13][14][15][16][17][18] and atom transfer radical polymerization (ATRP) [19][20][21][22][23][24][25][26][27][28][29]. Nevertheless, to our knowledge the direct synthesis of pNIPAAM block copolymers with permanently charged quaternized cationic monomers has not been reported yet.…”

Section: Introductionmentioning

confidence: 93%

Synthesis and association properties of thermoresponsive and permanently cationic charged block copolymers

Patrizi

Diociaiuti

Capitani³

et al. 2009

Polymer

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Section: Introductionmentioning

confidence: 93%

Synthesis and association properties of thermoresponsive and permanently cationic charged block copolymers

Patrizi

Diociaiuti

Capitani³

et al. 2009

Polymer

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“…These macromolecules are typically synthesized by transforming an ω‐hydroxy PEO segment into an ATRP,45, 78–83 a RAFT44, 84, 85 or a NMP64 macroinitiator (Scheme ). This synthetic route is also suitable for preparing poly(propylene oxide) (PPO) macroinitiators 80, 86, 87. Nevertheless, α,ω‐dihydroxy telechelic PEO can also be used for preparing triblock amphiphiles of the ABA type 88–90.…”

Section: At the Molecular Scale: Synthesis Of Building Blocks By Crpmentioning

confidence: 99%

Solution self‐assembly of tailor‐made macromolecular building blocks prepared by controlled radical polymerization techniques

Lutz

2006

Polymer International

136

116

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This review describes the preparation of colloidal aggregates (spherical micelles, cylindrical micelles, polymer vesicles, multicompartment micelles, polyion complexes, schizophrenic micelles) using bottom-up self-assembly approaches. In particular, it focuses primarily on the self-organization of well-defined macromolecular building blocks (macrosurfactants, polysoaps, polyelectrolytes) synthesized by controlled radical polymerization techniques such as atom transfer radical polymerization, reversible addition fragmentation transfer polymerization and nitroxide-mediated polymerization. The goal of this review is to highlight that these versatile techniques of polymer synthesis allow the preparation of unprecedented nanostructures in dilute solutions

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“…26 The ATRP macroinitiator was synthesized by reacting PPG 35 with 2.5 mol equiv of 2-bromoisobutyryl bromide in dry toluene in the presence of triethylamine (2.5 mol equiv) at 20°C for 24 h, as reported elsewhere. [27][28][29] ATRP was carried out at 50°C for 6 h. The copolymer was precipitated in hot water (60°C) and filtered out. It was dissolved in tetrahydrofuran (THF), and the solution was eluted through a silica gel column to remove the Cu(II) complex.…”

Section: Synthesis Of Paa 18 Ppo 35 Paa 18 Triblock Copolymermentioning

confidence: 99%

Cisplatin delivery vehicles based on stabilized polymeric aggregates comprising poly(acrylic acid) chains

Stoyanova

Petrov

Karadjova

et al. 2017

Polym J

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Stabilized polymeric aggregates (SPAs) comprising poly(acrylic acid) chains were studied as a delivery platform for cisplatin. SPAs were prepared by blending a poly(ethylene oxide)-block-poly(propylene oxide)-block-poly(ethylene oxide) triblock copolymer with a poly(acrylic acid)-block-poly(propylene oxide)-block-poly(acrylic acid) triblock copolymer and additional loading and photocrosslinking of pentaerythritol tetraacrylate. Dynamic light scattering analysis revealed particles with a hydrodynamic diameter of 176 nm and a monomodal particle size distribution. The stabilized polymeric aggregates were loaded with cisplatin by a ligand exchange reaction, achieving a high loading efficiency of 76%. A study on the release of complexes of platinum(II) from the particles in phosphate-buffered saline (PBS) and citrate buffer solution (CBS) at 37°C revealed a sustained release profile. More than 90% and nearly 80% of the loaded drug were released within 312 h in PBS and CBS, respectively. The in vitro cell viability assay indicated that cisplatin immobilized in the SPAs is less cytotoxic than the non-immobilized agent. The intracellular accumulation of the entrapped complex was comparable to that of the free drug.

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Thermoassociative Block Copolymers of Poly(N‐Isopropylacrylamide) and Poly(Propylene Oxide)

Cited by 29 publications

References 34 publications

Synthesis and association properties of thermoresponsive and permanently cationic charged block copolymers

Synthesis and association properties of thermoresponsive and permanently cationic charged block copolymers

Solution self‐assembly of tailor‐made macromolecular building blocks prepared by controlled radical polymerization techniques

Cisplatin delivery vehicles based on stabilized polymeric aggregates comprising poly(acrylic acid) chains

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