Thermoanalytical study of microspheres containing diltiazem hydrochloride

Hekmatara, T.; Regdon, Géza; Sipos, Péter; Erös, I.; Pintye‐Hódi, Klára

doi:10.1007/s10973-005-7303-6

Cited by 16 publications

(5 citation statements)

References 17 publications

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“…They are appropriate to use (fibers or granules as basic materials) for the microencapsulation of drugs having short biological half-life but frequent administration. It is important the long-term stability of controlled-release dosage forms too [7,[41][42][43][44]. The indiscriminate use of antifungal agents has led to the advancement of microorganisms tolerant to the various drugs used in the market [45].…”

Section: Discussionmentioning

confidence: 99%

Differential thermal analysis of the antibacterial effect of PLA-based materials planned for 3D printing

Maróti

Kocsis

Ferencz

et al. 2019

J Therm Anal Calorim

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Additive manufacturing technologies give many new application possibilities in our everyday life. Biomedical applications benefit a lot from 3D printing. In medical applications, several devices can be easily produced or prototyped with FFF/ FDM technologies, but we must minimize the contamination risk. New materials regularly appear on the market, recently specified as antibacterial, resulting from compounded silver nanoparticles. Because scientifically accurate and practical information is not available, this way, we lack information regarding mechanical and thermal stability of the printed products. In addition, these parameters are essential in the setting and optimizing the 3D printers. In our recent study, we aimed to analyze PLA, PLA-HDT as well as PLA-Ag nanocomposite in the form of additive manufacturing filament, with DTA/TG. The results showed that these composites, based on their thermal characteristics, can be suitable for 3D print biomedical devices such as orthoses, casts, medical models and also surgical guides; therefore, their further examination should be important, regarding mechanical characteristics and their possible antibacterial effect.

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Section: Discussionmentioning

confidence: 99%

Differential thermal analysis of the antibacterial effect of PLA-based materials planned for 3D printing

Maróti

Kocsis

Ferencz

et al. 2019

J Therm Anal Calorim

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“…Diltiazem hydrochloride (DL) is a benzothiazepine calcium–channel blocker with peripheral and coronary vasodilating effect with limited negative inotropic activity. Its short biological half‐life and thus frequent administration (usually three to four times a day) makes it a potential candidate for sustained or controlled release dosage forms 24. The present study aims at developing newly synthesized (PVA ‐co‐ PAA)/NaCl normal hydrogel (H), hydrogel microspheres (HM) and comparing the antihypertensive activity of DL from two formulations.…”

Section: Introductionmentioning

confidence: 99%

Comparative delivery of Diltiazem hydrochloride through synthesized polymer: Hydrogel and hydrogel microspheres

Ray¹,

Gils²,

Mohanta³

et al. 2009

J of Applied Polymer Sci

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In this study, interpenetrating polymer network (IPN) hydrogel based on polyvinyl alcohol (PVA) networking with polyacrylic acid (PAA) were prepared by a non-conventional emulsion method without any added crosslinker, using benzoyl peroxide as initiator and sodium chloride (NaCl) as additive. The IPN hydrogel was characterized by using Fourier transformed infrared (FTIR) spectrophotometry, Thermo gravimetric analysis (TGA), and Scanning electron microscopy (SEM). (PVA-co-PAA)/ NaCl normal IPN hydrogel (H) were fabricated into hydrogel microspheres (HM) by modified emulsion crosslinking method using glutaraldehyde-saturated toluene as crosslinker and were loaded with Diltiazem hydrochloride (DL). The IPN hydrogel showed more swelling in simulated intestinal fluid (SIF). (PVA-co-PAA)/NaCl HM for-mulation A1 showed comparatively higher DL entrapment (79%) and better control over DL release up to 24 h. By comparing antihypertensive activity of DL loaded two formulations in normotensive rats, HM formulation A1 found more effective in reducing blood pressure to 40.1%. The experimental results demonstrated that (PVA-co-PAA)/ NaCl HM had the greater potential than normal hydrogel to be used as a drug carrier. A single use of the prepared hydrogel microsphere system of DL can effectively control hypertension in rats. The system holds promise for clinical studies. V C 2009 Wiley Periodicals, Inc. J Appl Polym Sci 116: 959-968, 2010

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“…[8] The instrument was calibrated using high-purity indium metal as standard. The dynamic scans were taken in nitrogen atmosphere at the heating rate of 10°C/min.…”

Section: Methodsmentioning

confidence: 99%

“…All dynamic differential scanning calorimetry (DSC) studies were carried out on dupont thermal analyzer with 2010 DSC module. [ 8 ] The instrument was calibrated using high-purity indium metal as standard. The dynamic scans were taken in nitrogen atmosphere at the heating rate of 10°C/min.…”

Section: Methodsmentioning

confidence: 99%

Preparation and Evaluation of Mixture of Eudragit and Ethylcellulose Microparticles Loaded with Ranolazine for Controlled Release

Gowda¹,

Gowrav²,

Gangadharappa³

et al. 2011

Journal of Young Pharmacists

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To minimize the unwanted toxic effects of anti-anginal ranolazine by kinetic control of drug release, it was entrapped into gastro-resistant, biodegradable eudragit (EU) and ethyl cellulose (EC) binary blend using phase separation method. Ten formulations were prepared using different polymer blend ratios and solvent. The prepared microparticles were characterized for micromeritic properties, polymer drug compatibility by Fourier Transform Infrared Spectroscopy (FT-IR) and Differential Scannibg Calorimetry (DSC), and surface morphology by Scanning Electron Micrography (SEM). The yield of microparticles was up to 90% and more than 98% of the isolated microparticles are having volume mean diameter of 285 μm. The obtained angle of repose, percentage Carr's index and tapped density values were within the limits indicating good flow properties. The surface morphology revealed that particles were free-flowing, spherical, with minute pores and invert dents on the surface. The prepared microparticles were evaluated for percentage yield, encapsulation efficiency and in vitro release studies. FT-IR and DSC studies showed no chemical interaction between the drug and used polymers The in vitro drug release studies were carried out using pH 1.2 acid buffer and pH 7.4 phosphate buffer. EU acts as an excellent pH-dependent binder and helps to release the drug in the intestine. The drug release kinetics followed different transport mechanisms. Increasing the weight fractions of EU and decreased EC helps to control the drug release from the particles. From the differential (f1) and similarity factor (f2), Formulation F5 was the formulation most similar to the commercially available oral formulation as reference standard. The drug release performance was greatly affected by the materials used in microparticle preparations, which allow absorption in the intestinal tract.

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Thermoanalytical study of microspheres containing diltiazem hydrochloride

Cited by 16 publications

References 17 publications

Differential thermal analysis of the antibacterial effect of PLA-based materials planned for 3D printing

Differential thermal analysis of the antibacterial effect of PLA-based materials planned for 3D printing

Comparative delivery of Diltiazem hydrochloride through synthesized polymer: Hydrogel and hydrogel microspheres

Preparation and Evaluation of Mixture of Eudragit and Ethylcellulose Microparticles Loaded with Ranolazine for Controlled Release

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