Thermoanalytical characterization of clindamycin-loaded intravitreal implants prepared by hot melt extrusion

Tamaddon, Lana; Mostafavi, Sayed Abolfazl; Karkhane, Reza; Riazi‐Esfahani, Mohammad; Dorkoosh, Farid Abedin; Rafiee-Tehrani, Morteza

doi:10.4103/2277-9175.161563

Cited by 9 publications

(7 citation statements)

References 37 publications

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“…However, the absence of high-intensity bands for albendazole in the ABZ-PU spectrum suggests that most of the ABZ was incorporated into the core of PU nanoparticles. Also, no new absorption bands were detected in the spectrum of ABZ-PU NP thus suggesting that ABZ did not affect the PU structure and stability; these results are in agreement with other previous reports [55,65].…”

Section: Discussionsupporting

confidence: 92%

Solid Polymeric Nanoparticles of Albendazole: Synthesis, Physico-Chemical Characterization and Biological Activity

et al. 2020

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Albendazole is a benzimidazole derivative with documented antitumor activity and low toxicity to healthy cells. The major disadvantage in terms of clinical use is its low aqueous solubility which limits its bioavailability. Albendazole was incorporated into stable and homogeneous polyurethane structures with the aim of obtaining an improved drug delivery system model. Spectral and thermal analysis was used to investigate the encapsulation process and confirmed the presence of albendazole inside the nanoparticles. The in vitro anticancer properties of albendazole encapsulated in polyurethane structures versus the un-encapsulated compound were tested on two breast cancer cell lines, MCF-7 and MDA-MB-231, in terms of cellular viability and apoptosis induction. The study showed that the encapsulation process enhanced the antitumor activity of albendazole on the MCF-7 and MDA-MB-23 breast cancer lines. The cytotoxic activity manifested in a concentration-dependent manner and was accompanied by changes in cell morphology and nuclear fragmentation.

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Section: Discussionsupporting

confidence: 92%

Solid Polymeric Nanoparticles of Albendazole: Synthesis, Physico-Chemical Characterization and Biological Activity

et al. 2020

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“…The DSC curve of clindamycin showed an endothermic melting peak at 170.5 °C. Another sharp endothermic peak at 243 °C and an exothermic peak at 210 °C were also observed (Tamaddon et al, 2015). The DSC plot of PVA exhibited an endothermic melting peak at approximately 180°C and a second small endothermic peak presented at 210 °C, as previously reported by Andrade et al (2020).…”

Section: Dsc Measurementsupporting

confidence: 84%

Clindamycin peel-off mask film, an effective formulation for C. acnes treatment: characterization and microbiological activity

Morakul

Wongrakpanich²,

Teeranachaideekul³

et al. 2023

Indonesian J Pharm

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Clindamycin is the antibiotic of choice for treating Cutibacterium acnes (C. acnes) which was presented in various dosage forms such as topical solution, gel, and foam. In this current study, clindamycin was formulated as the peel-off mask gel, intending to form film, providing the drug release profile in a sustained manner leading to better antimicrobial efficacy and enabling peel-off after use. The peel-off mask gel was designed into many formulations with varying concentrations of film-forming agents. The major film-forming agent was 10 %w/w PVA that was combined with the additional film-forming agents PVP-K30 or SA. Clindamycin 1 %w/w was loaded in the selected formulations F18 (10 %w/w PVA and 20 %w/w PVP-K30) and F21 (10 %w/w PVA and 1.5 %w/w SA). The physical property evaluation of the peel-off mask gel showed that the types and concentrations of film-forming agents influenced the viscosity, spreadability, and film-forming ability. The film’s tensile strength indicating the preference of use was also determined. There was no interaction between the ingredients in the formulation evaluated by FT-IR, XRD, and DSC. The F18 and F21 formulations showed a good to very good spreadability and film-forming ability, a suitable tensile strength with a drying time of approximately 8 min, and pH 4-5. Both formulations provided the highest antimicrobial susceptibility for C. acnes compared to the blank film and the clindamycin solution indicating the potential to be developed as the new market formulation for acne treatment.

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“…It is clear that clindamycin’s Tm peak appears in all drug–polymer physical mixtures with minor changes in position, indicating that neither polymer used affected the crystalline nature of clindamycin HCl and the absence of interaction at solid state. The DSC results of clindamycin-polymer films shows the disappearance of the characteristic T m peak of the drug which can be explained by the transformation of clindamycin from an unstable crystalline form to its stable amorphous form during dissolving and re-precipitation processes [ 21 ]. Figure 8 shows the X-ray pattern of pure clindamycin with numerous sharp and distinct peaks at 2θ angle of 6.4°, 9.2°, 13.1°, 16.2°, 26.5° indicating crystalline nature of drug [ 13 ].…”

Section: Resultsmentioning

confidence: 99%

Investigation of Drug–Polymer Compatibility Using Chemometric-Assisted UV-Spectrophotometry

et al. 2017

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A simple chemometric-assisted UV-spectrophotometric method was used to study the compatibility of clindamycin hydrochloride (HC1) with two commonly used natural controlled-release polymers, alginate (Ag) and chitosan (Ch). Standard mixtures containing 1:1, 1:2, and 1:0.5 w/w drug–polymer ratios were prepared and UV scanned. A calibration model was developed with partial least square (PLS) regression analysis for each polymer separately. Then, test mixtures containing 1:1 w/w drug–polymer ratios with different sets of drug concentrations were prepared. These were UV scanned initially and after three and seven days of storage at 25 °C. Using the calibration model, the drug recovery percent was estimated and a decrease in concentration of 10% or more from initial concentration was considered to indicate instability. PLS models with PC3 (for Ag) and PC2 (for Ch) showed a good correlation between actual and found values with root mean square error of cross validation (RMSECV) of 0.00284 and 0.01228, and calibration coefficient (R2) values of 0.996 and 0.942, respectively. The average drug recovery percent after three and seven days was 98.1 ± 2.9 and 95.4 ± 4.0 (for Ag), and 97.3 ± 2.1 and 91.4 ± 3.8 (for Ch), which suggests more drug compatibility with an Ag than a Ch polymer. Conventional techniques including DSC, XRD, FTIR, and in vitro minimum inhibitory concentration (MIC) for (1:1) drug–polymer mixtures were also performed to confirm clindamycin compatibility with Ag and Ch polymers.

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Thermoanalytical characterization of clindamycin-loaded intravitreal implants prepared by hot melt extrusion

Cited by 9 publications

References 37 publications

Solid Polymeric Nanoparticles of Albendazole: Synthesis, Physico-Chemical Characterization and Biological Activity

Solid Polymeric Nanoparticles of Albendazole: Synthesis, Physico-Chemical Characterization and Biological Activity

Clindamycin peel-off mask film, an effective formulation for C. acnes treatment: characterization and microbiological activity

Investigation of Drug–Polymer Compatibility Using Chemometric-Assisted UV-Spectrophotometry

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