Thermo-sensitive complex micelles from sodium alginate- graft -poly( N -isopropylacrylamide) for drug release

Yu, Ning; Li, Guiying; Gao, Yurong; Jiang, Hua; Tao, Qian

doi:10.1016/j.ijbiomac.2016.01.066

Cited by 42 publications

(26 citation statements)

References 28 publications

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“…146 Prior to predicting and controlling the properties of a micellar system, the copolymers utilized should be well-defined. Depending on the nature of the polymer to be synthesized, the most appropriate polymerization reaction to use, such as anionic, ring-opening polymerization (ROP), or radical polymerization is determined.…”

Section: Synthesis Methods Of Thermosensitive Npsmentioning

confidence: 99%

Temperature-Responsive Smart Nanocarriers for Delivery Of Therapeutic Agents: Applications and Recent Advances

Karimi

Zangabad

Ghasemi

et al. 2016

ACS Appl. Mater. Interfaces

338

212

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Smart drug delivery systems (DDSs) have attracted the attention of many scientists, as carriers that can be stimulated by changes in environmental parameters such as temperature, pH, light, electromagnetic fields, mechanical forces, etc. These smart nanocarriers can release their cargo on demand when their target is reached and the stimulus is applied. Using the techniques of nanotechnology, these nanocarriers can be tailored to be target-specific, and exhibit delayed or controlled release of drugs. Temperature-responsive nanocarriers are one of most important groups of smart nanoparticles (NPs) that have been investigated during the past decades. Temperature can either act as an external stimulus when heat is applied from the outside, or can be internal when pathological lesions have a naturally elevated termperature. A low critical solution temperature (LCST) is a special feature of some polymeric materials, and most of the temperature-responsive nanocarriers have been designed based on this feature. In this review, we attempt to summarize recent efforts to prepare innovative temperature-responsive nanocarriers and discuss their novel applications.

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Section: Synthesis Methods Of Thermosensitive Npsmentioning

confidence: 99%

Temperature-Responsive Smart Nanocarriers for Delivery Of Therapeutic Agents: Applications and Recent Advances

Karimi

Zangabad

Ghasemi

et al. 2016

ACS Appl. Mater. Interfaces

338

212

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“…The main mechanism of the thermally induced water release above the LCST is a sharp transition from a hydrophilic state to a hydrophobic state at the LCST . Owing to this unique property, PNIPAM hydrogels have been extensively applied in many fields including drug release, self‐healing materials, tissue engineering, etc. Recently, it should be pointed out that copolymers composed of PNIPAM and biodegradable components forming semi‐interpenetrating polymeric networks (semi‐IPNs) have been developed, which usually possess characteristics of desired biocompatibility .…”

Section: Introductionmentioning

confidence: 99%

“…prepared thermo‐sensitive complex micelles assembled from biocompatible graft copolymers of sodium alginate‐ graft ‐PNIPAM and divalent metal ions for controlled drug release. The polymer micelles performed well for drug encapsulation and release ability . Slemming‐Adamsen et al .…”

Section: Introductionmentioning

confidence: 99%

Thermal and pH dual‐responsive hydrogels based on semi‐interpenetrating network of poly(N‐isopropylacrylamide) and collagen nanofibrils

Ding

Zhang

et al. 2019

Polymer International

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Hydrogels with environment-sensitive properties have great potential applications in the controlled drug release field. In this paper, hybrid hydrogels with semi-interpenetrating polymer networks (semi-IPNs), composed of poly(N-isopropylacrylamide) (PNIPAM) as the thermo-sensitive component by in situ polymerization and self-assembled collagen nanofibrils as the pH-sensitive framework, were prepared for controlled release of methyl violet as a model drug. From Fourier transform infrared spectroscopy and scanning electron microscopy, it was indicated that the crosslinking of PNIPAM in the presence of collagen nanofibrils led to the formation of semi-IPNs with homogeneous porous structure, and the semi-IPNs showed improved thermal stability and elastic properties compared with the native collagen as determined using differential scanning calorimetry and rheologic measurements. Furthermore, the semi-IPNs possessed swelling behaviors quite different from those of neat collagen or PNIPAM hydrogel under various pH values and temperatures. Correspondingly, as expected, the drug release behavior in vitro for semi-IPNs performed variously compared with that for single-component semi-IPNs, which revealed the tunable performance of semi-IPNs for release ability. Finally the thermo-and pH-responsive mechanism of the semi-IPNs was illuminated to provide guidance for the application of the thermo-and pH-sensitive collagen-based hybrid hydrogels in controlled drug delivery systems.

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“…The polymer micelle demonstrated good polydispersivity and excellent performance for incapsullation and the drug release. The superior metal-induced properties of sensitive polymer micelles indicate their application in controlled drug delivery systems [74]. The molecule weight (Mw) which affects the cytotoxicity of poly(NIPAM) was examined.…”

Section: Introductionmentioning

confidence: 99%

Hydrogels based on N-isopropylmethacrylamide and N-isopropylacrylamide

Urošević¹,

Nikolić²,

Ilić‐Stojanović³

et al. 2018

Adv Techol

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Hydrogels are three-dimensional polymer networks which have the capacity to retain a large quantity of water or biological fluids in the swollen state. Thermosensitive hydrogels have received special attention of reserachers since they represent a parameter which frequently changes in chemical, biological and physiological systems. Thermosensitive hydrogels have the critical solution temperature, i.e. they exhibit a substantial change in volume with the temperature change. Homopolymers poly(N-isopropylmethacrylamide) (poly(NIPMAM)) and poly(N-isopropylacrylamide) (poly(NIPAM)) are thermosensitive materials which have lately become the subject of intensive study. Monomer N-isopropylmethacrylamide, NIPMAM, enters into copolymerization with monomer N-isopropylacrylamide, NIPAM, in order to create a system with a phase transition temperature approximate to the human body temperature. In literature data there is available information on the synthesis and characterization of microgels, nanogels and copolymers based on NIPMAM and NIPAM. These thermosensitive polymer materials are used in controlled drug delivery and protein immobilization.

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Thermo-sensitive complex micelles from sodium alginate- graft -poly( N -isopropylacrylamide) for drug release

Cited by 42 publications

References 28 publications

Temperature-Responsive Smart Nanocarriers for Delivery Of Therapeutic Agents: Applications and Recent Advances

Temperature-Responsive Smart Nanocarriers for Delivery Of Therapeutic Agents: Applications and Recent Advances

Thermal and pH dual‐responsive hydrogels based on semi‐interpenetrating network of poly(N‐isopropylacrylamide) and collagen nanofibrils

Hydrogels based on N-isopropylmethacrylamide and N-isopropylacrylamide

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