Thermo-responsive polymers as surface active compounds: A review

Manfredini, Nicolò; Gardoni, Gianmaria; Sponchioni, Mattia; Moscatelli, Davide

doi:10.1016/j.eurpolymj.2023.112421

Cited by 6 publications

(2 citation statements)

References 165 publications

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“…Several thermoresponsive nanoscaffolds are proposed in the literature, with efforts towards the development of lower critical solution temperature (LCST) nanocarriers. 4,14,15 Indeed, the polymer chains of LCST-type nanocarriers shrink at temperatures above their LCST, inducing the release of the encapsulated drug. However, the drug is usually not entirely ejected from the NPs, due to a residual miscibility of the hydrophobic core with the payload beyond the LCST.…”

Section: Introductionmentioning

confidence: 99%

Zwitterionic nanoparticles for thermally activated drug delivery in hyperthermia cancer treatment

Colli,

Masi,

Jacchetti

et al. 2024

Nanoscale

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Section: Introductionmentioning

confidence: 99%

Zwitterionic nanoparticles for thermally activated drug delivery in hyperthermia cancer treatment

Colli,

Masi,

Jacchetti

et al. 2024

Nanoscale

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“…Two main behaviors have been reported, according to whether this sharp change in the solubility occurs by decreasing or increasing the environment temperature. In the former case, the binodal curve of the T cp as a function of the polymer volume fraction in the mixture has a maximum defined upper critical solution temperature (UCST), while in the latter the binodal curve shows a minimum defined lower critical solution temperature (LCST). − This smart and controllable behavior opened up a plethora of applications in sectors as diverse as oil and gas, − sensors, , and in particular biomedicine, − where thermoresponsive polymers are enabling fascinating and previously unexplored possibilities in tissue engineering and regenerative medicine.…”

Section: Introductionmentioning

confidence: 99%

Thermoresponsive Copolymers with Well-Defined Composition and Phase Separation Via Semi-Batch Free-Radical Polymerization in a Non-Polar Medium

Gardoni,

Menegon,

Sponchioni

et al. 2023

ACS Appl. Polym. Mater.

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Thermoresponsive polymers formulated in nonpolar media are finding a plethora of applications in the oil and gas and lubricant sectors. Their great adaptability mainly comes from the possibility of tuning their cloud point (T cp ), which is achieved by copolymerizing two or more monomers. In this direction, good control over the copolymer composition is crucial to ensure a sharp phase separation and, as a consequence, a prompt and well-defined response. For this reason, controlled radical polymerizations (CRPs) are often used to synthesize these materials. However, these pseudoliving polymerization techniques are still far from industrial maturity because of their cost and low polymerization rate. On the other hand, free-radical polymerization (FRP) is notoriously affected by the compositional drift of the copolymer chains, which for thermoresponsive polymers is reflected in broad phase separations. To overcome the disadvantages of FRP and guarantee remarkable control of the copolymer composition typical of CRPs, in this work we develop a semibatch power feed process for the copolymerization of diethylene glycol methyl ether methacrylate (EG 2 MA) and lauryl methacrylate in Dectol (i.e., a mixture of decane/toluene 50:50 v/v). First, their reactivity ratios were determined by analyzing the variation in the residual monomer phase composition over time at different initial molar ratios of the two monomers. These were subsequently employed for designing the inlet flow rate of the power feed strategy. Through this approach, we demonstrated for the first time that semibatch FRP is a valuable strategy to afford compositionally well-defined copolymers with a controllable upper critical solution temperature and sharp phase separations while maintaining high productivity and avoiding CRPs.

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Tetrazine-based dynamic covalent polymers as degradable extraction materials in sample preparation

Ortega-Zamora,

González-Sálamo,

Rivero

et al. 2024

Analytica Chimica Acta

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Thermo-responsive polymers as surface active compounds: A review

Cited by 6 publications

References 165 publications

Zwitterionic nanoparticles for thermally activated drug delivery in hyperthermia cancer treatment

Zwitterionic nanoparticles for thermally activated drug delivery in hyperthermia cancer treatment

Thermoresponsive Copolymers with Well-Defined Composition and Phase Separation Via Semi-Batch Free-Radical Polymerization in a Non-Polar Medium

Tetrazine-based dynamic covalent polymers as degradable extraction materials in sample preparation

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