Thermo-responsive nanofibers for on-demand biocompound delivery platform

Douaki, Ali; Tran, Thi Nga; Suarato, Giulia; Bertolacci, Laura; Petti, Luisa; Lugli, Paolo; Papadopoulou, Evie L.; Athanassiou, Athanassia

doi:10.1016/j.cej.2022.136744

Cited by 16 publications

(5 citation statements)

References 47 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Specific temperature-sensitive polymeric materials experience reduced solubility, leading to precipitation or phase separation. This unique characteristic can be harnessed to design and prepare nanocarrier materials for pesticides using temperature responsiveness. − Some commonly employed temperature triggers for these materials include n -hexadecane, PNIPAm, and their copolymers. These polymers undergo drastic chain collapse reactions above the LCST. − …”

Section: Stimulus-responsive Controlled Releasementioning

confidence: 99%

Recent Advances in Stimulus-Responsive Nanocarriers for Pesticide Delivery

Ma,

Li,

et al. 2024

J. Agric. Food Chem.

View full text Add to dashboard Cite

In an effort to make pesticide use safer, more efficient, and sustainable, micro-/nanocarriers are increasingly being utilized in agriculture to deliver pesticide-active agents, thereby reducing quantities and improving effectiveness. In the use of nanopesticides, the choice to further design and prepare pesticide stimulus-responsive nanocarriers based on changes in the plant growth environment (light, temperature, pH, enzymes, etc.) has received more and more attention from researchers. Based on this, this paper examines recent advancements in nanomaterials for the design of stimulus-responsive micro-/nanocarriers. It delves into the intricacies of preparation methods, material enhancements, in vivo/ex vivo controlled release, and application techniques for controlled release formulations. The aim is to provide a crucial reference for harnessing nanotechnology to pursue reduced pesticide use and increased efficiency.

show abstract

Section: Stimulus-responsive Controlled Releasementioning

confidence: 99%

Recent Advances in Stimulus-Responsive Nanocarriers for Pesticide Delivery

Ma,

Li,

et al. 2024

J. Agric. Food Chem.

View full text Add to dashboard Cite

show abstract

“…In addition to biomedical applications, PPC can also be modified for food packing materials [ 7 , 134 ], UV shielding materials [ 135 ], construction materials [ 136 ], agricultural mulching films [ 11 ], degradable surfactants [ 137 ], foaming and blowing materials [ 138 ], solid electrolytes and barriers [ 139 , 140 ] and smart materials [ 104 ] based on its outstanding properties. For a more comprehensive review of PPC in other applications, please refer to previous reviews [ 5 , 85 , 95 ].…”

Section: Other Applications Of Ppcmentioning

confidence: 99%

Poly(Propylene Carbonate)-Based Biodegradable and Environment-Friendly Materials for Biomedical Applications

Wang,

Li,

Yang

et al. 2024

IJMS

View full text Add to dashboard Cite

Poly(propylene carbonate) (PPC) is an emerging “carbon fixation” polymer that holds the potential to become a “biomaterial of choice” in healthcare owing to its good biocompatibility, tunable biodegradability and safe degradation products. However, the commercialization and wide application of PPC as a biomedical material are still hindered by its narrow processing temperature range, poor mechanical properties and hydrophobic nature. Over recent decades, several physical, chemical and biological modifications of PPC have been achieved by introducing biocompatible polymers, inorganic ions or small molecules, which can endow PPC with better cytocompatibility and desirable biodegradability, and thus enable various applications. Indeed, a variety of PPC-based degradable materials have been used in medical applications including medical masks, surgical gowns, drug carriers, wound dressings, implants and scaffolds. In this review, the molecular structure, catalysts for synthesis, properties and modifications of PPC are discussed. Recent biomedical applications of PPC-based biomaterials are highlighted and summarized.

show abstract

“…Many efforts have been made to explore the biodegradation behavior and mechanism of APCs, and some of these polymers, for example, poly(ethylene carbonate) (PEC), ,, poly(propylene carbonate), , and PTMC , have been used for drug delivery. Despite this, the specific mechanism of biodegradation for many APCs has yet to be determined, , especially for PTMC.…”

Section: Introductionmentioning

confidence: 99%

Investigating the Biodegradation Mechanism of Poly(trimethylene carbonate): Macrophage-Mediated Erosion by Secreting Lipase

Wang

Zhao

et al. 2023

Biomacromolecules

View full text Add to dashboard Cite

Poly(trimethylene carbonate) (PTMC), as one of the representatives of biodegradable aliphatic polycarbonates, has been found to degrade in vivo via surface erosion. This unique degradation behavior and the resulting nonacidic products make it more competitive with aliphatic polyesters (e.g., polylactide) in clinical practice. However, this surface degradation mechanism is complicated and not fully understood to date despite the findings that several reactive oxygen species and enzymes can specifically degrade PTMC in vitro. Herein, the biodegradation mechanism of PTMC was investigated by using possible degradation factors, distinct cell lines, and the inhibitors of these factors. The results demonstrate that PTMC undergoes a specific macrophage-mediated erosion. Macrophages tend to fuse into giant cells and elicit a typical inflammatory response by releasing proinflammatory cytokines. In addition, macrophages are suggested to primarily secrete enzymes (lipase specifically) to erode the PTMC bulk extracellularly as inhibiting their activity effectively prevented this eroding process. The clarification of the biodegradation mechanism in this work suggests that the degradation of PTMC highly depends on the foreign body response. Thus, it reminds the researchers to consider the effect of the microenvironment on the degradation and drug release of PTMC-based implantation devices and localized drug delivery systems.

show abstract

Thermo-responsive nanofibers for on-demand biocompound delivery platform

Cited by 16 publications

References 47 publications

Recent Advances in Stimulus-Responsive Nanocarriers for Pesticide Delivery

Recent Advances in Stimulus-Responsive Nanocarriers for Pesticide Delivery

Poly(Propylene Carbonate)-Based Biodegradable and Environment-Friendly Materials for Biomedical Applications

Investigating the Biodegradation Mechanism of Poly(trimethylene carbonate): Macrophage-Mediated Erosion by Secreting Lipase

Contact Info

Product

Resources

About