Thermo-responsive extraction of cadmium(II) ion with TPEN-NIPA gel. Effect of the number of polymerizable double bond toward gel formation and the extracting behavior

Quadruple Click: A Facile Pathway leading to Tetrakis(4‐(1,2,3‐triazolyl)methyl)‐ethylenediamine Derivatives as a New Class of Extracting Agents for Soft Metal Ions

“…The extraction of soft metal ions by triazole ethylenediamine derivatives 1 was then investigated in polymer gels. As polymer gels, in which TPEN derivatives were incorporated as cross‐linker, have been shown to extract soft metal ions,3b,c,e it is intriguing to apply related gels with 1 as a cross‐linker. In particular, polymer gels prepared by using N ‐isopropyl acrylamide (NIPA) as a monomer were revealed to exhibit a temperature‐dependent extraction performance.…”

Thermoresponsive extraction of cadmium(II) ions by poly(TPEN–NIPA) gels. Effect of chain length and branched spacer structure on gel formation and extraction behavior

“…Syntheses of pyridine derivatives bearing allyloxy moieties 3a-6a and TPEN derivative 1a were previously reported. [5][6][7] Reactions affording 3b-d, 4b-d, 5b-d and 6b-d were conducted in similar manners. Although the reaction of 2-methyl-4-nitropyridine-1-oxide with allylic alcohol 2a or 2d proceeded smoothly, harsh conditions were necessary to afford 3b and 3c.…”

“…The gel was shown to extract Cd II at low temperatures, whereas little extraction was observed at elevated temperatures. [5][6][7][8] N,N,N¢,N¢-(tetrakis-2-pyridylmethyl)ethylenediamine is recognized as a hexadentate ligand with six nitrogen donors and has been shown to chelate a variety of soft metal ions such as Hg, Cd, Au and Pd. [9][10][11][12][13] It was also shown to be effective for the chelation of f-block metals; the separation of minor actinides from high-level radioactive waste is a pressing issue.…”

“…7,8,[24][25][26][27][28][29] It was shown that poly(TPEN-NIPA) gel must be prepared from TPEN derivatives bearing at least three double-bond moieties to form a stable polymer gel and to show temperature-dependent changes in extraction behaviors. Accordingly, our concern centers on the relationship between the chain length and the branched structure of the spacer moiety between the polymer main chain and TPEN moiety.…”

Zinc Chelation Mediates the Lysosomal Disruption without Intracellular ROS Generation

“…N,N,N′,N′-Tetrakis(2-pyridylmethyl)ethylenediamine (TPEN) is a membrane-permeable hexadentate compound which chelates metal ions such as Cu 2+ , Zn 2+ , and Fe 2+ [ 1 , 2 ], but this intracellular chelator has shown a high affinity for zinc [ 3 – 5 ]. This special property permits the use of TPEN in a variety of settings, often as a tool to probe the functions of zinc in cell cultures.…”