Thermo-/pH-responsive preservative delivery based on TEMPO cellulose nanofiber/cationic copolymer hydrogel film in fruit packaging

Shaghaleh, Hiba; Hamoud, Yousef Alhaj; Xu, Xu; Liu, He; Wang, Shifa; Sheteiwy, Mohamed S.; Dong, Faqin; Guo, Lizhen; Qian, Yiwen; Li, Pengfei; Zhang, Shuangsheng

doi:10.1016/j.ijbiomac.2021.05.208

Cited by 40 publications

(6 citation statements)

References 44 publications

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“…It is also important to note that fib-CNF and carboxymethylcellulose (CMC) are already widely used as food additives [ 28 , 29 , 30 , 31 , 32 , 33 , 34 , 35 , 36 , 37 ].…”

Section: Discussionmentioning

confidence: 99%

Assessing the Safety of Mechanically Fibrillated Cellulose Nanofibers (fib-CNF) via Toxicity Tests on Mice: Single Intratracheal Administration and 28 Days’ Oral Intake

Yamashita,

Tokunaga,

Aoki

et al. 2024

Toxics

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Mechanically fibrillated cellulose nanofibers, known as fib-CNF (fiber length: 500 nm; diameter: 45 nm), are used in composites and as a natural thickener in foods. To evaluate their safety, we conducted a 28-day study in mice with inhalation exposure at 0.2 mg/body and oral administration of 400 mg/kg/day. Inhalation exposure to fib-CNF caused transient weight loss, changes in blood cell counts, and increased lung weights. These changes were attributed to adaptive responses. The oral administration of fib-CNF for 28 days resulted in no apparent toxic effects except for a slight decrease in platelet counts. The fib-CNF administration using the protocols studied appears to be safe in mice.

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“…It is also important to note that fib-CNF and carboxymethylcellulose (CMC) are already widely used as food additives [ 28 , 29 , 30 , 31 , 32 , 33 , 34 , 35 , 36 , 37 ].…”

Section: Discussionmentioning

confidence: 99%

Assessing the Safety of Mechanically Fibrillated Cellulose Nanofibers (fib-CNF) via Toxicity Tests on Mice: Single Intratracheal Administration and 28 Days’ Oral Intake

Yamashita,

Tokunaga,

Aoki

et al. 2024

Toxics

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“…The study examines the growth kinetics of escherichia coli and staphylococcus aureus against hydrogel films with 2,2,6,6-Tetramethylpiperidine-1-oxyl(TEMPO)-oxidized cellulose nanofiber/cationic copolymer, showing a moderate bacterial colony inhibition of around 40%. The hydrogel films displayed significant antifungal efficiency against aspergillus niger, particularly TEMPO-oxidized nanocellulose/cationic poly(N-isopropylacrylamide-co-acrylamide) ( NA TOCNF/CP NIPAM-AM ), which completely inhibited growth, demonstrating the potential of naringenin(NA) integrated into hydrogel films for enhanced antimicrobial effectiveness under acidic and/or high-temperature conditions, optimizing naringenin release rates and reducing naringenin concentration on fruit surfaces by 25–50% ( Figure 6 b) [ 155 ].…”

Section: Application Fields Of Cellulose Hydrogelsmentioning

confidence: 99%

Exploring Applications and Preparation Techniques for Cellulose Hydrogels: A Comprehensive Review

Tang,

Fang,

Lee

2024

Gels

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Cellulose hydrogels, formed either through physical or chemical cross-linking into a three-dimensional network from cellulose or its derivatives, are renowned for their exceptional water absorption capacities and biocompatibility. Rising demands for sustainable materials have spurred interest in cellulose hydrogels, attributed to their abundant supply, biodegradability, and non-toxic nature. These properties highlight their extensive potential across various sectors including biomedicine, the food industry, and environmental protection. Cellulose hydrogels are particularly advantageous in applications such as drug delivery, wound dressing, and water treatment. Recent large-scale studies have advanced our understanding of cellulose preparation and its applications. This review delves into the fundamental concepts, preparation techniques, and current applications of cellulose hydrogels in diverse fields. It also discusses the latest advances in nano-lignin-based hydrogels, providing a comprehensive overview of this promising material and offering insights and guidance for future research and development.

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“…The targeted delivery of albumin to the intestines was achieved through diffusion and polymer structure relaxation. Temperature-responsive hydrogels are another type of carrier that respond to the changes in the temperature of the environment they are in by swelling or shrinking, which allows for the bioactive compounds to be released from the gel structure [221]. Temperature-responsive hydrogels might not be used to deliver bioactive substances to the stomach, small intestine, and colon but instead for oral (buccal) delivery.…”

Section: Bioactive Substances Targeted Transport and Controlled Releasementioning

confidence: 99%

Binary Hydrogels: Induction Methods and Recent Application Progress as Food Matrices for Bioactive Compounds Delivery—A Bibliometric Review

Hilal

Florowska

Wroniak

2023

Gels

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Food hydrogels are biopolymeric materials made from food-grade biopolymers with gelling properties (proteins and polysaccharides) and a 3D network capable of incorporating large amounts of water. They have sparked considerable interest because of their potential and broad application range in the biomedical and pharmaceutical sectors. However, hydrogel research in the field of food science is still limited. This knowledge gap provides numerous opportunities for implementing their unique properties, such as high water-holding capacity, moderated texture, compatibility with other substances, cell biocompatibility, biodegradability, and high resemblance to living tissues, for the development of novel, functional food matrices. For that reason, this article includes a bibliometric analysis characterizing research trends in food protein–polysaccharide hydrogels (over the last ten years). Additionally, it characterizes the most recent developments in hydrogel induction methods and the most recent application progress of hydrogels as food matrices as carriers for the targeted delivery of bioactive compounds. Finally, this article provides a future perspective on the need to evaluate the feasibility of using plant-based proteins and polysaccharides to develop food matrices that protect nutrients, including bioactive substances, throughout processing, storage, and digestion until they reach the specific targeted area of the digestive system.

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Thermo-/pH-responsive preservative delivery based on TEMPO cellulose nanofiber/cationic copolymer hydrogel film in fruit packaging

Cited by 40 publications

References 44 publications

Assessing the Safety of Mechanically Fibrillated Cellulose Nanofibers (fib-CNF) via Toxicity Tests on Mice: Single Intratracheal Administration and 28 Days’ Oral Intake

Assessing the Safety of Mechanically Fibrillated Cellulose Nanofibers (fib-CNF) via Toxicity Tests on Mice: Single Intratracheal Administration and 28 Days’ Oral Intake

Exploring Applications and Preparation Techniques for Cellulose Hydrogels: A Comprehensive Review

Binary Hydrogels: Induction Methods and Recent Application Progress as Food Matrices for Bioactive Compounds Delivery—A Bibliometric Review

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