Thermitase-Catalyzed Hydrolysis of the C-Terminal Ester Group of Protected Peptide Ester Derivatives

Enzymic Protecting Group Techniques

“…From the respective dicyclopentyl ester 58 it preferably (ratio 20:1) removes the 7-ester in 90% yield78 (Figure 18). In addition, the enzyme thermitase and the alkaline protease from B. subtilis (vide supra) hold a great potential for the selective manipulation of dicarboxylic that the selective deprotection of peptides can be achieved advantageously by making use of enzymatic reactions.…”