Thermally Triggered Triazolinedione–Tyrosine Bioconjugation with Improved Chemo- and Site-Selectivity
Elias Denijs,
Kamil Unal,
Kevin Bevernaege
et al.
Abstract:A bioconjugation strategy is reported that allows the derivatization of tyrosine side chains through triazolinedione-based "Y-clicking". Blocked triazolinedione reagents were developed that, in contrast to classical triazolinedione reagents, can be purified before use, can be stored for a long time, and allow functionalization with a wider range of cargoes and labels. These reagents are benchstable at room temperature but steadily release highly reactive triazolinediones upon heating to 40 °C in buffered media… Show more
This highlight provides an account of the discovery and advances in the tyrosine-click (Y-click) reaction and its extensive application in the mapping of proteins, imaging of living cells, and in the fields of analytical and medicinal chemistry.
This highlight provides an account of the discovery and advances in the tyrosine-click (Y-click) reaction and its extensive application in the mapping of proteins, imaging of living cells, and in the fields of analytical and medicinal chemistry.
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