Thermally stable bioactive borosilicate glasses: Composition–structure–property correlations

Chakraborty, Anustup; Prasad, Sakthi; Kant, Shashi; Vel, Rathina; Tripathy, Sucheta; Sinha, Prasanta Kumar; Dey, Krishna Kishor; Lodhi, Lekhan; Ghosh, Manasi; Allu, Amarnath R.; Bodhak, Subhadip; Biswas, Kaushik

doi:10.1557/s43578-023-01017-6

Cited by 1 publication

(15 citation statements)

References 79 publications

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“…The borosilicate bioactive glass compositions (Table 1) were synthesized using a conventional melt-quench technique as described in our previous work. 46 Glasses were melted at temperatures ranging from 1150 to 1350 °C depending upon the composition.…”

Section: Glass Synthesismentioning

confidence: 99%

“…A similar chemical shift referencing technique and magic angle spinning parameters as mentioned in our previous publication were followed for the measurements. 46 2.2.2. Raman Spectroscopy.…”

Section: Structural Analysis 221 Mas Nmr Spectroscopymentioning

confidence: 99%

“…47 The in vitro bioactivity test for 1, 3, and 7 days was performed adopting similar procedures as mentioned elsewhere. 46 Simultaneously, SBF supernatants were analyzed by inductively coupled plasma atomic emission spectroscopy (ICP-AES, Spectro Genesis) to quantify Si 4+ and B 3+ ion concentrations after each time point (1, 3, and 7 days). Similarly, supernatant pH was measured using a pH meter (Eutech, Singapore) having a temperature measurement accessory.…”

Section: In Vitromentioning

confidence: 99%

“…To evaluate the antibacterial properties of the sintered bioactive glass coating, the broth microdilution method coupled with colony-forming unit (CFU) counting was employed following protocols as mentioned in our previous work. 46 Briefly, the initial bacterial suspensions with a 10 7 CFU/mL concentration were obtained by culturing a single colony of E. coli and S. aureus strains in Luria−Bertani (LB) broth followed by further dilution. The prepared bacterial suspensions were supplemented with sintered glass powders (representing the behavior of the sintered coating) at concentrations of 10 and 20 mg/mL.…”

Section: In Vitro Cytocompatibility Of Coatingmentioning

confidence: 99%

“…The B 4 units with two Si and two B neighbors give rise to the peak at 1.75−2.12 ppm range, while those with one Si and 3 B neighbors contribute a peak at the 4−4.9 ppm range. 46,51,55 Overall, four different borate units could be identified, and their relative abundance as calculated from the relative peak area is furnished in Table S5 (see Supporting Information). The relative abundance data disclose a higher proportion of B 4 units compared to B 3 units for all the studied samples in accordance with our previous studies on borosilicate bioactive glasses.…”

Section: Mas Nmr Spectroscopymentioning

confidence: 99%

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Tailored Bioactive Glass Coating: Navigating Devitrification Toward a Superior Implant Performance

Chakraborty,

Bodhak,

Tah

et al. 2024

ACS Biomater. Sci. Eng.

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The development of well-adherent, amorphous, and bioactive glass coatings for metallic implants remains a critical challenge in biomedical engineering. Traditional bioactive glasses are susceptible to crystallization and exhibit a thermal expansion mismatch with implant materials. This study introduces a novel approach to overcome these limitations by employing systematic Na 2 O substitution with CaO in borosilicate glasses. In-depth structural analysis (MD simulations, Raman spectroscopy, and NMR) reveals a denser network with smaller silicate rings, enhancing thermal stability, reducing thermal expansion, and influencing dissolution kinetics. This tailored composition exhibited optimal bioactivity (in vitro formation of bone-like apatite within 3 days) and a coefficient of thermal expansion closely matching Ti-6Al-4V, a widely used implant material. Furthermore, a consolidation process, meticulously designed with insights from crystallization kinetics and the viscosity-temperature relationship, yielded a crack-free, amorphous coating on Ti-6Al-4V substrates. This novel coating demonstrates excellent cytocompatibility and strong antibacterial action, suggesting superior clinical potential compared with existing technologies.

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Section: Glass Synthesismentioning

confidence: 99%

Section: Structural Analysis 221 Mas Nmr Spectroscopymentioning

confidence: 99%