Thermally induced double proton transfer in GG and wobble GT base pairs: A possible origin of the mutagenic guanine

Elementary Molecular Mechanisms of the Spontaneous Point Mutations in DNA: A Novel Quantum-Chemical Insight into the Classical Understanding

“…5). A potential pathway for the generation of the mutagenic amino-enol form of guanine is reported by Padermshoke et al (Padermshoke et al, 2008), who investigated DPT reactions in three guanine-guanine dimers, a guanine-thymine wobble base pair, and a model compound 4(3H)-pyrimidinone dimer using ab initio MO calculations and liquid-phase IR spectroscopy. The calculations suggest that the DPT processes in these dimers are energetically accessible and temperature-dependent IR measurements of the model compound reveal that slight thermal energy can induce the DPT reaction, and hence the enol tautomer can appear.…”

“…It is also generally accepted in the literature that wobble base pairs (Gua·Thy and Ade·Cyt) (Brown et al, 1985;Crick, 1966;Hunter et al, 1986;Kennard, 1985;Padermshoke et al, 2008;Patel et al, 1982aPatel et al, , 1982bPatel et al, , 1984aPatel et al, , 1984b formed by bases in their canonical tautomeric forms www.intechopen.com…”

The effect of oxidation on the stability of G:C base pair: a MP2 study

“…A proper description of these non-bonded interactions helps to understand the basic principles governing the formation of the 3D nucleic acid architectures [2,3]. Owing to the importance, there have been numerous studies, experimental [4] and computational [5,6], concerned with the association of nucleotide base pairs.…”

MP2 study on the hydrogen-bonding interaction between 5-hydroxymethyl-uracil and DNA bases: A, C, G, T

“…A proper description of these non-bonded interactions helps to understand the basic principles governing the formation of the 3D nucleic acid architectures [2,3]. Due to the importance, there have been numerous studies, experimental [4] and computational [5,6], concerned with the association of nucleotide base pairs.…”