Thermal thresholds, vibrotactile thresholds and finger systolic blood pressures in dockyard workers exposed to hand-transmitted vibration

Lindsell, Christopher J.; Griffin, Michael J.

doi:10.1007/s004200050389

Cited by 32 publications

(21 citation statements)

References 18 publications

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“…The present study showed that thermal perception thresholds for warmth and cold as well as vibration and pain perception thresholds were significantly more deteriorated among patients with hand-arm vibration syndrome than in healthy controls, which agrees with previous studies 8,9,[13][14][15][16] . These findings suggest that both small and large sensory nerve fibers are impaired in vibration-induced neuropathy.…”

Section: Discussionsupporting

confidence: 82%

Thermal Perception Threshold Testing for the Evaluation of Small Sensory Nerve Fiber Injury in Patients with Hand-Arm Vibration Syndrome.

et al. 2000

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The aim of the present study was to investigate whether thermal perception threshold testing is a useful method that could replace pain threshold testing in the evaluation of small sensory nerve fiber injury in vibration-induced neuropathy. Vibration, pain, and thermal (warm and cold) perception thresholds were examined on both middle fingers of 50 patients with hand-arm vibration syndrome and 29 healthy controls of similar age. The patients were divided into three subgroups according to the Stockholm Workshop sensorineural scale. Thermal (warm and cold) thresholds as well as vibration and pain thresholds were significantly more deteriorated among the patients than in the controls. Among the patients, warm thresholds elevated and cold thresholds lowered according to the Stockholm Workshop scale. Thermal thresholds were significantly correlated with pain thresholds, and the sensitivity of the thermal threshold testing tended to be greater than that of the pain threshold testing. The present findings indicate that thermal threshold testing for warm and cold perception can be a useful substitute for pain threshold testing to examine small nerve fiber injury in vibration-induced neuropathy.

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Section: Discussionsupporting

confidence: 82%

Thermal Perception Threshold Testing for the Evaluation of Small Sensory Nerve Fiber Injury in Patients with Hand-Arm Vibration Syndrome.

et al. 2000

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“…, with vibration magnitudes around the perception threshold. Repeated exposures to vibration magnitudes close to the perception threshold do not appear to cause systematic or significant increases in 125-Hz thresholds at the fingertips (20). The low-magnitude and shortduration exposure in the present study may not have been sufficient to cause a change in the sensitivity of the Pacinian channel (22,28).…”

Section: Circulatory Effects Of Acute Vibrationcontrasting

confidence: 39%

Reductions in finger blood flow in men and women induced by 125-Hz vibration: association with vibration perception thresholds

Yao

Griffin

2011

Journal of Applied Physiology

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Ye Y, Griffin MJ. Reductions in finger blood flow in men and women induced by 125-Hz vibration: association with vibration perception thresholds. J Appl Physiol 111: 1606 -1613, 2011. First published September 15, 2011 doi:10.1152/japplphysiol.00407.2011.-Vibration of one hand reduces blood flow in the exposed hand and in the contralateral hand not exposed to vibration, but the mechanisms involved are not understood. This study investigated whether vibration-induced reductions in finger blood flow are associated with vibrotactile perception thresholds mediated by the Pacinian channel and considered sex differences in both vibration thresholds and vibration-induced changes in digital circulation. With force and vibration applied to the thenar eminence of the right hand, finger blood flow and finger skin temperature were measured in the middle fingers of both hands at 30-s intervals during seven successive 4-min periods: 1) pre-exposure with no force or vibration, 2) pre-exposure with force, 3) vibration 1, 4) rest with force, 5) vibration 2, 6) postexposure with force, and 7) recovery with no force or vibration. A 2-N force was applied during periods 2-6 and 125-Hz vibration at 0.5 and 1.5 ms Ϫ2 root mean square (r.m.s.; unweighted) was applied during periods 3 and 5, respectively. Vibrotactile thresholds were measured at the thenar eminence of right hand using the same force, contact conditions, and vibration frequency. When the vibration magnitude was greater than individual vibration thresholds, changes in finger blood flow were correlated with thresholds (with both 0.5 and 1.5 ms Ϫ2 r.m.s. vibration): subjects with lower thresholds showed greater reductions in finger blood flow. Women had lower vibrotactile thresholds and showed greater vibration-induced reductions in finger blood flow. It is concluded that mechanoreceptors responsible for mediating vibration perception are involved in the vascular response to vibration.

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“…Low concentrations of NO have been found to enhance tumor growth, whereas overproduction of NO can induce apoptosis through unknown mechanisms in neural cells, macrophages, cancer cells, and other cell types (Sang et al, 2010). NO administration has been shown to increase the radiosensitivity of mouse mammary carcinoma EMT-6 cells (Janssens et al, 1999), Chinese hamster V79 cells (Pavord et al, 1996), and sarcomatous SCK cells (Lindsell and Griffin, 1999). NO interacts with DNA and leads to single-stranded DNA breaks, which enhances MnSOD-induced tumor-growth inhibition.…”

Section: Discussionmentioning

confidence: 99%

Bidirectional Regulation of Manganese Superoxide Dismutase (MnSOD) on the Radiosensitivity of Esophageal Cancer Cells

Sun

Hu²,

Wang³

et al. 2012

Asian Pacific Journal of Cancer Prevention

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The mitochondrial antioxidant protein manganese superoxide dismutase (MnSOD) may represent a new type of tumor suppressor protein. Overexpression of the cDNA of this gene by plasmid or recombinant lentiviral transfection in various types of cancer leads to growth suppression both in vitro and in vivo. We previously determined that changes in MnSOD expression had bidirectional effects on adriamycin (ADR) when combined with nitric oxide (NO). Radiation induces free radicals in a manner similar to ADR, so we speculated that MnSOD combined with NO would also have a bidirectional effect on cellular radiosensitivity. To examine this hypothesis, TE-1 human esophageal squamous carcinoma cells were stably transfected using lipofectamine with a pLenti6-DEST plasmid containing human MnSOD cDNA at moderate to high overexpression levels or with no MnSOD insert. Blastidicin-resistant colonies were isolated, grown, and maintained in culture. We found that moderate overexpression of MnSOD decreased growth rates, plating efficiency, and increased apoptosis. However, high overexpression increased growth rates, plating efficiency, and decreased apoptosis. When combined with NO, moderate overexpression of MnSOD increased the radiosensitivity of esophageal cancer cells, whereas high MnSOD overexpression had the opposite effect. This finding suggests a potential new method to kill certain radioresistant tumors and to provide radioresistance to normal cells.

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Thermal thresholds, vibrotactile thresholds and finger systolic blood pressures in dockyard workers exposed to hand-transmitted vibration

Abstract: Vascular and neurological signs produced by hand-transmitted vibration can occur independently, but the principal vascular symptom (i.e. attacks of blanching) and some commonly reported neurological symptoms (i.e. sensations of numbness and tingling) may be related.

Cited by 32 publications

References 18 publications

Thermal Perception Threshold Testing for the Evaluation of Small Sensory Nerve Fiber Injury in Patients with Hand-Arm Vibration Syndrome.

Thermal Perception Threshold Testing for the Evaluation of Small Sensory Nerve Fiber Injury in Patients with Hand-Arm Vibration Syndrome.

Reductions in finger blood flow in men and women induced by 125-Hz vibration: association with vibration perception thresholds

Bidirectional Regulation of Manganese Superoxide Dismutase (MnSOD) on the Radiosensitivity of Esophageal Cancer Cells

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