Thermal studies on metal complexes of 5-nitrosopyrimidine derivatives IV

Abstract

The thermal decomposition processes of the complexes of 6-amino-5-nitrosouracil with Fe(ll), Co01), Ni(ll) and Cu(il) have been studied using "IG and DSC techniques. Dehydration energies have been calculated from the DSC curves.

New Aspects on the Origin of Color in the Solid State. Coherently Shifting of the Protons in Violurate Crystals

“…In an attempt to address these questions we have focused on a systematic study of nucleic acids such as uracil, thymine, and cytosine. These are interesting species for the purpose of controlling self-assembly because, in addition to their known affinity for complementary bases, they can also form complexes with transition metals, 16 thereby allowing the generation of metal-organic selfassembled structures. One attractive template appeared to be violuric acid and especially violurate salts.…”

Inhibition of Superoxide Dismutase from Ascaris suum by Benzimidazoles and Synthesized Pyrimidine and Glycine Derivatives

“…These compounds showed considerably less inhibiInhibition of SOD from A. smon Pharmacology 1996;52:61-68tory effect on host's SOD than on parasite's SOD (table 3). In the case of pyrimidine com pounds, it has been demonstrated earlier that they lack toxicity to mammals [5], Compari son of the results summarized in tables 1 and 3 leads us to suggest that this group of com pounds may become a source of particularly effective anthelmintics, with an intrinsically specific inhibitory action on parasite energy metabolism when used at low concentrations.…”

“…Here we assess the effects of several puta tive drugs against SOD of the parasite: (1) a series of benzimidazoles which are known to be powerful broad-spectrum anthelmintics; (2) several pyrimidine derivatives, of which some thiopyrimidine analogues possess effec tive antibacterial, antifungal, antiviral, and insecticidal activities [5], and (3) several gly cine derivates which, as the pyrimidine deriv atives mentioned above, are efficient chela tors of inorganic ions such as iron, zinc, and manganese. These compounds can, therefore, act as inhibitors of enzymes containing a me tallic ion as the prosthetic group [6], as in the case of SOD.…”

Thermal studies on Ni(II), Cu(II) and Pd(II) complexes of 6-amino-5-formyluracil and its N-methyl derivatives

“…For this reason and in connection with our studies on the synthesis, characterization and thermal behaviour of derivatives of biological importance [14][15][16][17][18][19][20][21][22], we describe here the thermal behaviour of tJour pyrimidine derivatives, 6-amino-5-formyluracil (HFU), 6-amino-l-methyl-5-formyluracil (1-HFU), 6-amino-3-m~thyl-5-formyluracil (3-HFU) and 6-amino-l,3-dimethyl-5-formyluracil (HDFU), and the new Ni(II), Cu(II) and Pd(II) complexes of these pyrimidine derivatives. Experimental HFU and its N-methylated derivatives were synthesized according to Pfleiderer [22], using 6-aminouracil and its methylated derivatives as starting materials [23][24].…”