Thermal stress in Danio rerio : a link between temperature, light, thermo-TRP channels, and clock genes

Jerônimo, Rodrigo; Moraes, Maria Nathália; Assis, Leonardo Vinícius Monteiro de; Ramos, Bruno; Rocha, Thainá; Castrucci, Ana Maria de Lauro

doi:10.1016/j.jtherbio.2017.02.009

Cited by 23 publications

(42 citation statements)

References 62 publications

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“…In recent years, it has become apparent that there are other chromophores operating in different regions of the spectrum . The most important alternative chromophore appears to be transient receptor potential (TRP) ion channels that can be activated by light or heat . An example is TRPV1 that can be activated by blue or green light and by longer wavelength NIR light (980 nm) that targets water in the form of nanostructured exclusion zone water clusters .…”

Section: Introductionmentioning

confidence: 99%

Non‐mammalian Hosts and Photobiomodulation: Do All Life‐forms Respond to Light?

Hamblin

Huang

Heiskanen

2018

Photochem & Photobiology

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Photobiomodulation (PBM), also known as low-level laser (light) therapy, was discovered over 50 years ago, but only recently has it been making progress toward wide acceptance. PBM originally used red and near-infrared (NIR) lasers, but now other wavelengths and non-coherent light-emitting diodes (LEDs) are being explored. The almost complete lack of side effects makes the conduction of controlled clinical trials relatively easy. Laboratory research has mainly concentrated on mammalian cells (normal or cancer) in culture, and small rodents (mice and rats) as models of different diseases. A sizeable body of work was carried out in the 1970s and 1980s in Russia looking at various bacterial and fungal cells. The present review covers some of these studies and a recent number of papers that have applied PBM to so-called "model organisms." These models include flies (Drosophila), worms (Caenorhabditis elegans), fish (zebrafish) and caterpillars (Galleria). Much knowledge about the genomics and proteomics, and many reagents for these organisms already exist. They are inexpensive to work with and have lower regulatory barriers compared to vertebrate animals. Other researchers have studied different models (snails, sea urchins, Paramecium, toads, frogs and chickens). Plants may respond to NIR light differently from visible light (photosynthesis and photomorphogenesis) but PBM in plants has not been much studied. Veterinarians routinely use PBM to treat non-mammalian patients. The conclusion is that red or NIR light does indeed have significant biologic effects conserved over many different kingdoms, and perhaps it is true that "all life-forms respond to light."

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Section: Introductionmentioning

confidence: 99%

Non‐mammalian Hosts and Photobiomodulation: Do All Life‐forms Respond to Light?

Hamblin

Huang

Heiskanen

2018

Photochem & Photobiology

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“…Subsequent studies with those genes reinforce the dependence on temperature for proper entrainment of the circadian system in these species by showing a response in expression of cry1aa and per1a genes in S. carolitertii when subjected to a simulated scenario of moderate climate change (Jesus et al 2017). Other studies connected the circadian system with stress response through a network involving heat-shock proteins (HSP) (Jerônimo et al 2017).…”

Section: Introductionmentioning

confidence: 88%

“…This pathway can affect the expression of per2 in mammals as this gene possesses in its promoter a heatshock element (HSE) sequence (Kornmann et al 2007;Tamaru et al 2011;Chappuis et al 2013). Other authors studying this same relation in zebrafish hypothesize that HSF1 activation is related to circadian regulation in at least two ways: (1) HSP activation improves the ability of the organism to deal with thermal stress, but HSP also interacts with BMAL1 to maintain the optimal function of the circadian system and (2) HSF1 activates other circadianrelated genes as per2 that may result in synchronization of the circadian machinery and maintain the outputs of the circadian system fully functional (Jerônimo et al 2017). In the same work, Jerônimo et al (2017) identified the channel TRPV1 (Transient receptor potential cation channel subfamily V member 1), a thermo-sensitive receptor, as an integrant part of zebrafish circadian rhythm by playing a role in heat-mediated hsp90 and per2 responses.…”

Section: Introductionmentioning

confidence: 99%

“…Circadian rhythms can also be entrained by temperature (Liu et al 1998;Tsuchiya et al 2003;Lahiri et al 2005;Chappuis et al 2013;Jerônimo et al 2017). In mammals it was demonstrated that peripheral cells in vitro could sense the change of room temperature as a cue for entrainment of circadian system (Tsuchiya et al 2003).…”

Section: Introductionmentioning

confidence: 99%

“…In mammals it was demonstrated that peripheral cells in vitro could sense the change of room temperature as a cue for entrainment of circadian system (Tsuchiya et al 2003). In zebrafish, temperature has also an important role in circadian clock (Lahiri et al 2005;Jerônimo et al 2017), and it was proposed that temperature could entrain the phase of the system by driving expression levels of per3, and other clock genes (namely cry2 and cry1ba) via an alternative hypothetical enhancer upstream the E-box (Lahiri et al 2005). In this model, per1b (formerly known as per4) promoter integrates temperature and light regulatory input from the E-boxes together with regulation by other temperature-driven elements (Lahiri et al 2005).…”

Section: Introductionmentioning

confidence: 99%

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Adaptation and convergence in circadian-related genes in Iberian freshwater fish

Moreno

Sousa

Jesus

et al. 2019

Preprint

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The circadian clock is a biological timing system that improves the inherent ability of organisms to deal with environmental fluctuations. It is regulated by daily alternations of light but can also be affected by temperature. Fish, as ectothermic, have an increased dependence on the environmental temperature and thus are good models to study the integration of temperature within the circadian system. Here, we studied four species of freshwater fish of Squalius genus, distributed across a latitudinal gradient in Portugal with variable conditions of light and temperature. We identified and characterised the expected sixteen genes belonging to four main gene families (Cryptochromes, Period, CLOCK and BMAL) involved in the circadian system. We conducted phylogenetic analysis and tested these genes for the presence of signatures of selection based on dN/dS that revealed the presence of mutations under positive selection in nine genes. Furthermore, we analysed functional features of the proteins and found that these mutations alter protein isoelectric point and aliphatic index. Additionally, in 50% of the genes we found a pattern of convergence uncovered by the phylogenetic clustering of S. aradensis and S. pyrenaicus from Almargem, which inhabit basins with similar environmental conditions. Although this clustering can be explained by incomplete lineage sorting, evidence of positive selection in one gene in the two species and similar functional features in seven proteins are consistent with convergence at protein level. Our results highlight the importance of integrating sequence-based functional protein characterisation with dN/dS-based methods when studying the molecular adaptation of species.

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