Abstract:TP53 is one of the most important tumor suppressor genes and is known as the “genetic guardian”. Targeting the MDM2-p53 loop is an attractive tumor treatment strategy. Herein, an organic PCM with a melting point of 43.5℃ was prepared by using biocompatible fatty acids and alcohols. PCM was used to co-encapsulate a photosensitizer (IR780) and a novel MDM2-p53 inhibitor (APG-115). The final prepared multifunctional temperature responsive release nanoplatform (PIA NPs) can not only effectively deliver APG-115 and… Show more
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