Thermal Stabilization of Vulnerable Plaques

Casscells, S. Ward; Lal, Birendra N.; Madjid, Mohammad; Tewatia, Tarun; Aboshady, Ibrahim; Geng, Yong–Jian; Willerson, James T.

doi:10.1002/9780470987575.ch23

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2007

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“…Heating increases selective macrophage apoptosis, probably by inactivation of NF-kB and melting of oxidized cholesterol crystals. 29 Although some consider these effects as beneficial, the free cholesterol and apoptotic debris are not adequately removed in advanced lesions. 30 As a consequence, the increased amount of UCP2-positive macrophages in advanced plaques may stimulate inflammatory responses and enlargement of the necrotic core and may ultimately lead to plaque rupture.…”

Section: Discussionmentioning

confidence: 99%