Thermal stability, thermodynamics and kinetic study of (R)-(–)-phenylephrine hydrochloride in nitrogen and air environments

Wan, Yameng; He, Hui; Li, Fanfan; Zhang, Pengshuai; Gao, Xuejin; Wang, Yujie; Gan, Zhenjie; Li, Yanxun

doi:10.1007/s10973-022-11911-6

Cited by 3 publications

(1 citation statement)

References 34 publications

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“…Kinetic studies are, nowadays, of great importance in the characterization of pharmaceuticals, including active pharmaceutical ingredients, excipients, and even coating and packaging materials [1][2][3][4]. The degradation processes that occur can be physical (crystallization of amorphous drugs, transitions in crystalline states, moisture adsorption, formation, and growth of crystals) or chemical (hydrolysis, oxidation, photolysis, dehydration, and racemization).…”

Section: Introductionmentioning

confidence: 99%

Kinetic Investigation of the Oxidative Thermal Decomposition of Levonorgestrel

Ridichie,

Ledeţi,

Peter

et al. 2023

Processes

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In this study, we have focused on studying the heterogenous degradation kinetics regarding the decomposition of the emergency contraceptive agent levonorgestrel (LNG), which is a second-generation synthetic progestogen that is the active component of the racemic mixture of norgestrel. The degradation processes of the active pharmaceutical ingredient (API) were compared with the ones obtained from a model system containing the API along with the excipients that are found in a commercialized pharmaceutical formulation in a mass ratio of 1:1 (LNGMIX), in order to observe if the excipients have a stabilizing or destabilizing effect on the degradation of this progestogen. To achieve this, the following investigational methods were used: FTIR (Fourier transform infrared) spectroscopy and thermal analysis (TG/DTG/DSC analysis). For the kinetic analysis, the data obtained from two main decomposition processes observed on the DTG curves were used and processed with a preliminary method, namely ASTM E698, and two isoconversional methods: Friedman and Flynn–Wall–Ozawa. The isoconversional study revealed that the decomposition mechanisms of both LNG and LNGMIX are complex, and the excipients have a stabilizing effect on the decomposition of the API in tablet.

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Section: Introductionmentioning

confidence: 99%

Kinetic Investigation of the Oxidative Thermal Decomposition of Levonorgestrel

Ridichie,

Ledeţi,

Peter

et al. 2023

Processes

View full text Add to dashboard Cite

show abstract

Kinetic Investigation of Oxidative Thermal Decomposition of Levonorgestrel

Ridichie,

Ledeţi,

Peter

et al. 2023

Preprint

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In this study, we have focused on studying the heterogenous degradation kinetics of regarding the decomposition of emergency contraceptive agent levonorgestrel (LNG), which is a second-generation synthetic progestogen that is the active component of the racemic mixture of norgestrel. The degradation processes of the active pharmaceutical ingredient (API) were compared with the ones obtained from model system containing the API along with the excipients that are found in a commercialized pharmaceutical formulation in a mass ratio of 1:1 (LNGMIX), in order to observe if the excipients have a stabilizing or destabilizing effect for the degradation of this progestogen. To achieve this, the following investigational methods were used: FTIR (Fourier transform infrared) spectroscopy and thermal analysis (TG/DTG/DSC analysis). For the kinetic analysis the data obtained from two main decomposition processes observed on the DTG curves were used and processed with a preliminary method, namely ASTM E698 and two isoconversional methods: Friedman and Flynn-Wall-Ozawa. The isoconversional study revealed that the decomposition mechanism of both LNG and LNGMIX are complex, and the excipients have a stabilizing effect over decomposition of API in tablet.

show abstract