Thermal stability evaluation of doping compounds before GC-MS analysis by DSC

Hadef, Youcef; Kaloustian, J.; Nicolay, Alain; Portugal, Henri

doi:10.1007/s10973-006-8300-0

Cited by 8 publications

(2 citation statements)

References 21 publications

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“…It has been reported that this degradation could be explained by a possible dehydration of the alcoholic function (catalyzed by sulfuric acid present in the molecule) and then oxidation (Hadef et al, 2008; Raula et al, 2008; Xu et al, 2010). The DSC scans for both the drug as received and nanoparticles of albuterol were similar with no change in the melting points (Table 5).…”

Section: Resultsmentioning

confidence: 99%

Nanoparticle agglomerates of fluticasone propionate in combination with albuterol sulfate as dry powder aerosols

El-Gendy

Pornputtapitak

Berkland

2011

European Journal of Pharmaceutical Sciences

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Particle engineering strategies remain at the forefront of aerosol research for localized treatment of lung diseases and represent an alternative for systemic drug therapy. With the hastily growing popularity and complexity of inhalation therapy, there is a rising demand for tailor-made inhalable drug particles capable of affording the most proficient delivery to the lungs and the most advantageous therapeutic outcomes. To address this formulation demand, nanoparticle agglomeration was used to develop aerosols of the asthma therapeutics, fluticasone or albuterol. In addition, a combination aerosol was formed by drying agglomerates of fluticasone nanoparticles in the presence of albuterol in solution. Powders of the single drug nanoparticle agglomerates or of the combined therapeutics possessed desirable aerodynamic properties for inhalation. Powders were efficiently aerosolized (~75% deposition determined by cascade impaction) with high fine particle fraction and rapid dissolution. Nanoparticle agglomeration offers a unique approach to obtain high performance aerosols from combinations of asthma therapeutics.

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Section: Resultsmentioning

confidence: 99%

Nanoparticle agglomerates of fluticasone propionate in combination with albuterol sulfate as dry powder aerosols

El-Gendy

Pornputtapitak

Berkland

2011

European Journal of Pharmaceutical Sciences

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“…In this sense, previous works have used DSC in the analysis of apprehended preparations of AASs for the detection of the melting point of the supposed active ingredient as an indicative if the sample was falsified or not, generating satisfactory results (Berneira et al, 2019). In another research paper, authors compared the effect of derivatization of anabolic agents using DSC in order to detect a potential enhancement on their thermal stability for GC-MS analysis showing that silylation prevented degradation at higher temperatures (Hadef et al, 2008).…”

Section: Unconventional Techniquesmentioning

confidence: 99%

Extraction and analytical approaches in the forensic evaluation of anabolic androgenic steroid formulations

Berneira

Poletti

Freitas

et al. 2021

WIREs Forensic Science

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Anabolic androgenic steroids are controlled or prohibited substances worldwide since their abusive usage can lead to extensive side effects. For forensic purposes, apprehended formulations of anabolic agents have to be analyzed to determine their components as well as possible adulterants and contaminants. Nevertheless, there are no comprehensive reviews in the field in order to compile the methods and analytical techniques that have been described so far.Therefore, the aim of this work was to review the analytical techniques and methods of extraction available for the analysis of formulations of anabolic agents. In this sense, 76 research works that analyzed formulations of anabolic agents from 1979 to 2021 were reviewed and distributed under the extraction methods and the analytical techniques employed by the authors. Generally, ultrasonic-assisted extraction associated with methanol as extractor solvent is the procedure of choice with little contribution of solid or liquid-liquid extraction. According to the literature, there are several analytical tools available for the analysis of these substances, although gas and liquid chromatography coupled to mass spectrometry as well as spectroscopic techniques are frequently employed. Nonetheless, novel techniques have been developed in order to decrease analysis time, cost, and sample preparation, which are important features in the expressive numbers of anabolic agents apprehended yearly. Therefore, the application of adequate methods of extraction coupled to suitable analytical techniques can be efficient forensic tools in order to contest the illicit supply of anabolic androgenic steroids providing consistent evidence to legal courts.

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Current Awareness in Drug Testing and Analysis

2009

Drug Testing and Analysis

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In order to keep subscribers up‐to‐date with the latest developments in their field, John Wiley & Sons are providing a current awareness service in each issue of the journal. The bibliography contains newly published material in the field of drug testing and analysis. Each bibliography is divided into 18 sections: 1 Reviews; 2 Sports doping ‐ General; 3 Steroids; 4 Peptides; 5 Diuretics; 6 CNS agents; 7 Equine; 8 Recreational drugs ‐ General; 9 Stimulants; 10 Hallucinogens; 11 Narcotics; 12 Forensics; 13 Alcohol; 14 Tobacco; 15 Homeland security; 16 Workplace; 17 Product authenticity; 18 Techniques. Within each section, articles are listed in alphabetical order with respect to author. If, in the preceding period, no publications are located relevant to any one of these headings, that section will be omitted.

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Thermal stability evaluation of doping compounds before GC-MS analysis by DSC

Cited by 8 publications

References 21 publications

Nanoparticle agglomerates of fluticasone propionate in combination with albuterol sulfate as dry powder aerosols

Nanoparticle agglomerates of fluticasone propionate in combination with albuterol sulfate as dry powder aerosols

Extraction and analytical approaches in the forensic evaluation of anabolic androgenic steroid formulations

Current Awareness in Drug Testing and Analysis

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