Thermal stability and storage of human insulin

Richter, Bernd; Bongaerts, Brenda; Metzendorf, Maria‐Inti

doi:10.1002/14651858.cd015385

Cited by 4 publications

(5 citation statements)

References 38 publications

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“…Insulin pens, unused cartridges, and vials should be stored in a refrigerator between 2°C and 8°C until their expiration date. [ 17 ] Freezing insulin can cause it to become unusable, and storing it in a deep freezer can affect its bioavailability. Pens should not be stored with needles attached to avoid clogging and insulation leaks.…”

Section: Discussionmentioning

confidence: 99%

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Errors in diabetic insulin therapy and the vitality of proper precautions in Bangladesh: Real-life insights from the developing world

Tulsan,

Laila,

Patel

et al. 2024

Journal of Family Medicine and Primary Care

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Background: Insulin therapy errors can have life-threatening consequences in patients with diabetes. Given the increasing prevalence of diabetes and insulin therapy in Bangladesh, it is crucial to identify and prevent these errors. This study uses case-based clinical experiences to thematically analyze insulin therapy errors and propose preventive measures. The study aims to provide valuable insights into the challenges faced in managing insulin therapy in a developing country setting and the importance of involving various stakeholders. Materials and Methods: This is a qualitative research that used a case study approach to identify and analyze errors in insulin therapy in diabetic patients who had experienced adverse clinical consequences. The cases were thematically analyzed to generate insights into current global health problems resulting from erroneous insulin therapy. Results: The two case studies highlight potential risks of errors in insulin therapy, including poor glycemic control, complications, and death. The analysis also highlights the importance of careful monitoring, checks, and communication among health-care providers, patients, and pharmacists to prevent such errors. In addition, it emphasizes the need for education and awareness among patients and health-care providers to ensure safe and effective insulin therapy. Conclusion: Accurate insulin therapy is crucial for diabetes management and preventing adverse outcomes. Identified themes emphasize improved communication, education, and monitoring to minimize therapy errors. Insights from this study can inform policies and practices for better patient outcomes. Further research can identify the root causes and develop interventions to prevent errors, leading to improved quality of life for diabetics.

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Section: Discussionmentioning

confidence: 99%

“…When traveling, insulin should be kept in insulated bags or thermos flasks to prevent exposure to temperatures exceeding 30°C. [ 17 ] It is best to keep insulin in carry-on luggage when traveling by plane to avoid exposure to extreme temperatures, especially freezing.…”

Section: Discussionmentioning

confidence: 99%

Errors in diabetic insulin therapy and the vitality of proper precautions in Bangladesh: Real-life insights from the developing world

Tulsan,

Laila,

Patel

et al. 2024

Journal of Family Medicine and Primary Care

View full text Add to dashboard Cite

show abstract

“…According to a recent review, human insulin can withstand higher temperatures and longer durations without losing its effectiveness than previously believed 8 . The study included data from 17 studies, suggesting that unopened insulin vials, pens or prefilled plastic syringes can be stored at temperatures up to 25°C for 6 months and up to 37°C for 2 months without a significant loss of potency.…”

Section: Do We Need To Keep Insulin Refrigerated?mentioning

confidence: 99%

Update on technologies, medicines and treatments

O'Neill

2024

Diabet Med

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“…When in use, insulin is regularly exposed to the previously mentioned environmental risk factors and in the case of insulin pumps, which is worn close to the body, not only is the temperature in the reservoir increased, but constant movement can accelerate fibril formation 158 When in use, insulin can be stored at room temperature (below 25 or 30°C) for up to 4 weeks 145,155,159 The time period recommended for use after opening a vial varies between 10 days and 8 weeks for different insulin formulations.…”

Section: Administration and Storage Of Insulinmentioning

confidence: 99%

“…158 • When in use, insulin can be stored at room temperature (below 25 or 30 C) for up to 4 weeks. 145,155,159 • The time period recommended for use after opening a vial varies between 10 days and 8 weeks for different insulin formulations.…”

Section: Insulin Storage Recommendations For Insulin In Usementioning

confidence: 99%