Thermal Stability and Kinetic Study of Fluvoxamine Stability in Binary Samples with Lactose

Abstract

Purpose: In the present study the incompatibility of FLM (fluvoxamine) with lactose in solid state mixtures was investigated. The compatibility was evaluated using different physicochemical methods such as differential scanning calorimetry (DSC), Fourier-transform infrared (FTIR) spectroscopy and mass spectrometry. Methods: Non-Isothermally stressed physical mixtures were used to calculate the solid–state kinetic parameters. Different thermal models such as Friedman, Flynn–Wall–Ozawa (FWO) and Kissinger–Akahira–Sunose (KAS) were used for the characterization of the drug-excipient interaction. Results: Overall, the incompatibility of FLM with lactose as a reducing carbohydrate was successfully evaluated and the activation energy of this interaction was calculated. Conclusion: In this research the lactose and FLM Maillard interaction was proved using physicochemical techniques including DSC and FTIR. It was shown that DSC- based kinetic analysis provides fast and versatile kinetic comparison of Arrhenius activation energies for different pharmaceutical samples.

Evaluation the Effect of Amine Type on the Non-isothermally Derived Activation Energy for the Interaction of 3 Antidepressant Drugs with Lactose

“…Selected DSC thermograms of (A) FLM, lactose and FLM- lactose 1:1 W/W binary mixture 10 (B) SER, lactose and SER- lactose 1:1 W/W binary mixture 11 (C) DOX, lactose and DOX- lactose 1:1 W/W binary mixture 12 (β=10) [Presented with permission].…”

“…Selected DSC thermograms of (A) FLM-lactose 10 (B) SER-lactose 11 (C) DOX-lactose 1:1 binary mixtures at different heating rates (β=2.5, 10, 15) [Presented with permission].…”

“…Multiple scanning method using DSC at different heating rates and isoconversional calculation procedures are fast and easy alternatives to the conventional method, in order to calculate solid-state kinetic parameters. 8-10…”

Analytical Investigation of the Possible Chemical Interaction of Methyldopa with Some Reducing Carbohydrates Used as Pharmaceutical Excipients

“…Although maillard incompatibility in pharmaceutical dosage forms has gained considerable attention in recent years, pharmaceutical industries still utilize this reducing excipient in the manufactured formulations. 16-25…”

Comparative physicochemical stability and clinical anti‐wrinkle efficacy of transdermal emulgel preparations of 5% sodium ascorbyl phosphate and or ascorbic acid on human volunteers

“…The best analytical approach to quantify the remaining drug after stability tests is defined as high-pressure liquid chromatography. [4][5][6][7][8] Spiclin and coworkers have claimed that "Sodium ascorbyl phosphate (SAP), a hydrophilic derivative of ascorbic acid (AA), has improved stability arising from its chemical structure". 9 Based on literature review, no comparative stability evaluations and clinical anti-wrinkle efficacy of transdermal emulgel preparations of (SAP) and (AA) on human volunteers have been performed yet and this is the first study to compare "final product stability" of ascorbic acid and sodium ascorbyl phosphate in a pharmaceutical formulation in the same conditions of manufacturing and storage and also compares the anti-wrinkle efficacy and safety on human volunteers.…”