Thermal stability and decomposition of pharmaceutical compounds

Lizarraga, Elena; Zabaleta, C.; Palop, Juan Antonio

doi:10.1007/s10973-006-7746-4

Cited by 20 publications

(2 citation statements)

References 6 publications

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“…The diacids are commercially available and the dianilides are readily prepared from the corresponding acid chlorides. The dianilides are typically high-melting solids that are quite stable . The structures of 1 − 6 are shown in Figure .…”

Section: Resultsmentioning

confidence: 99%

Halide Ions Complex and Deprotonate Dipicolinamides and Isophthalamides: Assessment by Mass Spectrometry and UV−Visible Spectroscopy

Carasel

Yamnitz

Winter³

et al. 2010

J. Org. Chem.

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The F(-), Cl(-), and Br(-) binding selectivity of bis(p-nitroanilide)s of dipicolinic and isophthalic acids was studied by using competitive electrospray mass spectrometry and UV-Visible spectroscopy. Both hosts prefer binding Cl(-) over either F(-) or Br(-). Host deprotonation was observed to some extent in all experiments in which the host was exposed to halide ions. When F(-) was present, host deprotonation was often the major process, whereas little deprotonation was observed by Cl(-) or Br(-), which preferred complexation. A solution of either host changed color when mixed with a F(-), H(2)PO(4)(-), di- or triphenylacetate solution.

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Section: Resultsmentioning

confidence: 99%

Halide Ions Complex and Deprotonate Dipicolinamides and Isophthalamides: Assessment by Mass Spectrometry and UV−Visible Spectroscopy

Carasel

Yamnitz

Winter³

et al. 2010

J. Org. Chem.

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“…Oxidative degradation pathways are shown in Scheme 3 (Figure 4c), which may exhibit oxidation of the amino and hydroxyl groups to the oxidized forms and formation of N-oxide in the amide moiety. Thermal degradation in Scheme 4 (Figure 4d) shows the possible suggested parts of the drug that may be affected by heat as the amide group and the ester group (Lizarraga, Zabaleta, & Palop, 2007).…”

Section: Degradation Hypothesismentioning

confidence: 99%

Accelerated stability study of the ester prodrug remdesivir: Recently FDA‐approved Covid‐19 antiviral using reversed‐phase‐HPLC with fluorimetric and diode array detection

Hamdy

Moneim

Kamal

2021

Biomedical Chromatography

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Remdesivir (RDV) is the first antiviral drug, approved by the Food and Drug Administration, to treat severe acute respiratory syndrome coronavirus 2. RDV is a relatively new chemical entity, 'ester prodrug', with no reported stability profile.Due to the urgency of its use and thus fast production, it is important to develop a stability-indicating method for its assay. Chromatographic separation was carried out on a C18 column (250 Â 4.6 mm, 5 μm) with dual detection: diode array at 240 nm and fluorescence at λ ex/em 245/390 nm. Isocratic elution of acetonitrile and distilled water (acidified with phosphoric acid, pH 4) in the ratio of 55:45 (v/v), respectively, was used. The linearity range using HPLC-diode array detection was 0.1-15 μg/mL, whereas that using fluorimetric detection was 0.05-15 μg/mL. As per the International Conference on Harmonization guidelines, RDV has been degraded by accelerated alkaline, acidic, neutral hydrolysis, oxidative, heat, and photolytic stress conditions. Possible degradation hypothesis of the parent molecule has been suggested and illustrated. The proposed methods have achieved selective determination of the intact drug with no peaks overlapping in all assumptions. Extensive degradation confirms threatened drug stability at thermal and basic hydrolytic stressing. The developed methods were fully validated and proved suitable for quality control routine analysis of RDV in raw material and pharmaceutical dosage forms.

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Synthesis, antimicrobial and thermal studies of nitropyridine-substituted double armed benzo-15-crown-5 ligands; alkali (Na+ and K+) and transition metal (Ag+) complexes; reduction of nitro compounds

Koçoğlu

Hayvalı

Öğütçü

et al. 2022

J Incl Phenom Macrocycl Chem

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Thermal stability and decomposition of pharmaceutical compounds

Cited by 20 publications

References 6 publications

Halide Ions Complex and Deprotonate Dipicolinamides and Isophthalamides: Assessment by Mass Spectrometry and UV−Visible Spectroscopy

Halide Ions Complex and Deprotonate Dipicolinamides and Isophthalamides: Assessment by Mass Spectrometry and UV−Visible Spectroscopy

Accelerated stability study of the ester prodrug remdesivir: Recently FDA‐approved Covid‐19 antiviral using reversed‐phase‐HPLC with fluorimetric and diode array detection

Synthesis, antimicrobial and thermal studies of nitropyridine-substituted double armed benzo-15-crown-5 ligands; alkali (Na+ and K+) and transition metal (Ag+) complexes; reduction of nitro compounds

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