“…Many data, based on different heat treatments in one cell line, using altered pH, heat modifying agents or development of thermotolerance have suggested a causal relationship between heat killing and heat radiosensitization (Konings and van der Meer-Kalverkamp 1980, Freeman et al 1981, Djordjevic 1983, Haveman 1983, Raaphorst and Azzam 1983, Dewey 1983, Holahan et al 1984, van Rijn et al 1984 although other data do not show this relationship (Lunec and Parker 1980, Mivechi and Hofer 1983, Nielsen 1983, Hartson-Eaton et al 1984. The different results of these investigations may possibly be explained by the differences in cell lines used and in the different heat schedules employed.…”