Thermal properties of Ni-substituted LaCoO3 perovskite

Abstract

With the objective of exploring the unknown thermodynamic behavior of LaCo 1-x Ni x O 3 family, we present here an investigation of the temperature-dependent (10K ≤ T ≤ 300K) thermodynamic properties of LaCo 1-x Ni x O 3 (x=0.1, 0.3, 0.5). The specific heat of LaCoO 3 with Ni doping in the perovskite structure at B-site has been studied by means of a Modified Rigid Ion Model (MRIM). This replacement introduces large cation variance at B-site hence the specific heat increases appreciably. We report here probably for the first time the cohesive energy, Reststrahlen frequency (υ) and Debye temperature (θ D ) of LaCo 1-x Ni x O 3 compounds.

Antidepressants for osteoarthritis

“…Pain is considered, by people with osteoarthritis, to be the most important symptom they experience (Tallon 2000). However, the causes of pain in osteoarthritis are multifactorial, complex and poorly understood (Thakur 2014). With increasing severity of radiographic osteoarthritis, the presence of pain increases, although the severity of pain is not strongly related to the structural severity of the disease (Felson 2005).…”

“…Whilst some structural changes within the joint itself, affecting bone and the synovium, may lead to local tissue damage that stimulates pain fibres (nociceptive pain), cartilage, often considered the target tissue in this condition, is aneural. It is becoming increasingly evident that maladaptive pain processing mechanisms also occur, with central pain sensitisation contributing to the pain experience in people with osteoarthritis (Thakur 2014). There are no established disease modifying treatments for osteoarthritis.…”

“…It is also affected by a component of neuropathic pain, which is defined as pain that is initiated or caused by a primary lesion or dysfunction affecting the somatosensory system (Treede 2008). These phenomena have been found to be present in 5% to 50% of patients with osteoarthritis (Thakur 2014). In a single cohort of patients with osteoarthritis, up to 70% of participants were reported to have evidence of pain sensitisation (Thakur 2014).…”

“…These phenomena have been found to be present in 5% to 50% of patients with osteoarthritis (Thakur 2014). In a single cohort of patients with osteoarthritis, up to 70% of participants were reported to have evidence of pain sensitisation (Thakur 2014). The presence of pain sensitivity increases with the severity and duration of symptomatic osteoarthritis (Thakur 2014).…”

“…In a single cohort of patients with osteoarthritis, up to 70% of participants were reported to have evidence of pain sensitisation (Thakur 2014). The presence of pain sensitivity increases with the severity and duration of symptomatic osteoarthritis (Thakur 2014). It is therefore possible that by targeting central pain processing mechanisms (instead of purely nociceptive tissue induced pain) as would occur via the use of antidepressant medications, pain may be better controlled in osteoarthritis.…”