Thermal Properties of Biological Tissue Gel-Phantoms in a Wide Low-Temperature Range

Agafonkina, I. V.; Belozerov, A. G.; Berezovsky, Yu. M.; Королев, И. А.; Пушкарев, А. В.; Tsiganov, D. I.; Шакуров, А. В.; Жердев, А. А.

doi:10.1007/s10891-021-02356-z

Cited by 11 publications

(7 citation statements)

References 31 publications

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“…The data that represent the temperature difference between brass, copper and monolithic sapphire applicators were obtained for the jel-based tissue phantom (see ref. [42]), which has the thermal properties similar to living tissues [56]. In that study, the applicators were of the same size and were cooled down at the same conditions.…”

Section: Resultsmentioning

confidence: 99%

Manufacturing of Sapphire Crystals with Variable Shapes for Cryosurgical Applications

Dolganova,

Zotov,

Rossolenko

et al. 2024

Crystals

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Consideration of sapphire shaped crystals as the material for manufacturing of medical instruments expands the opportunities of various approaches for diagnostics, exposure and treatment. Due to physical, mechanical and chemical properties of sapphire, as well as to its complex shape, such instruments are capable to demonstrate better performance for medical applications comparing to common tools. However, the manufacturing of high quality sapphire crystal with such geometry is still a complex issue, that usually requires application of various crystal growth techniques assisted with the automated weight control system. In this work, we consider one of such cases, that is the growth of a sapphire crystal, which can be applied for cryosurgery as an applicator due to a hollow-monolithic shape transition. Its hollow part can be filled with coolant in order to enable fast freezing of biological tissue during application. For this aim, it is of high importance to exclude the appearance of inclusions during the shape transition. To overcome this problem, we suggest using of noncapillary shaping (NCS) technique of crystal growth and study the weight signal measured during the manufacturing. We obtain the analytical description of the weight signal alteration that can be used as the program equation to control the crystal shape. We experimentally demonstrate the advantage of using such crystal for cryosurgery and obtaining faster ice-ball formation inside the model gelatin-based medium in comparison with the usage of the monolithic sapphire applicator of the same diameter. The demonstrated ability can be applied for future development of cryosurgical tools, while the analytical description of the weight signal could find its application for NCS manufacturing of sapphire crystals for other purposes.

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Section: Resultsmentioning

confidence: 99%

Manufacturing of Sapphire Crystals with Variable Shapes for Cryosurgical Applications

Dolganova,

Zotov,

Rossolenko

et al. 2024

Crystals

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show abstract

“…The 5% w/v agar-agar gel, mimicking the surrounding intestinal structures, was prepared following. 10 Reproducible endoscope and temperature sensor positions were achieved by a 3-dimensional-printed, multicomponent, customized fixation jig. The gastroscope and colonoscope were directed vertically toward the tissue surface (ie, touching with circular frontal plane of endoscope tip), whereas the duodenoscopes were oriented laterally (ie, touching the endoscope tube).…”

Section: Methodsmentioning

confidence: 99%

Preclinical Assessment of Tissue Effects by Gastrointestinal Endoscope Tip Temperature

Jäger¹,

Morales-Orcajo²,

Gager

et al. 2023

Current Therapeutic Research

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“…7 a. Here ultrasonic gel is used as its thermal properties are more stable and it thermal conductivity is close to biological tissues 61 . The overall thickness of the fabricated sample was ~ 1500 µm, and the thickness of the introduced ultrasound gel was ~ 330 µm.…”

Section: Methodsmentioning

confidence: 99%

Label-free photothermal optical coherence microscopy to locate desired regions of interest in multiphoton imaging of volumetric specimens

Ravichandran

Hur

Kim

et al. 2023

Sci Rep

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Biochip-based research is currently evolving into a three-dimensional and large-scale basis similar to the in vivo microenvironment. For the long-term live and high-resolution imaging in these specimens, nonlinear microscopy capable of label-free and multiscale imaging is becoming increasingly important. Combination with non-destructive contrast imaging will be useful for effectively locating regions of interest (ROI) in large specimens and consequently minimizing photodamage. In this study, a label-free photothermal optical coherence microscopy (OCM) serves as a new approach to locate the desired ROI within biological samples which are under investigation by multiphoton microscopy (MPM). The weak photothermal perturbation in sample by the MPM laser with reduced power was detected at the endogenous photothermal particles within the ROI using the highly sensitive phase-differentiated photothermal (PD–PT) OCM. By monitoring the temporal change of the photothermal response signal of the PD–PT OCM, the hotspot generated within the sample focused by the MPM laser was located on the ROI. Combined with automated sample movement in the x–y axis, the focal plane of MPM could be effectively navigated to the desired portion of a volumetric sample for high-resolution targeted MPM imaging. We demonstrated the feasibility of the proposed method in second harmonic generation microscopy using two phantom samples and a biological sample, a fixed insect on microscope slide, with dimensions of 4 mm wide, 4 mm long, and 1 mm thick.

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Thermal Properties of Biological Tissue Gel-Phantoms in a Wide Low-Temperature Range

Cited by 11 publications

References 31 publications

Manufacturing of Sapphire Crystals with Variable Shapes for Cryosurgical Applications

Manufacturing of Sapphire Crystals with Variable Shapes for Cryosurgical Applications

Preclinical Assessment of Tissue Effects by Gastrointestinal Endoscope Tip Temperature

Label-free photothermal optical coherence microscopy to locate desired regions of interest in multiphoton imaging of volumetric specimens

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