Thermal Properties and Morphology of Poly(3‐Hydroxybutyrate‐<i>co</i>‐3‐Hydroxyvalerate) with Poly(Caprolactone Triol) Mixtures

Wessler, Katiusca; Nishida, Maurício Hajime; Silva, João; Pezzin, Ana Paula Testa; Pezzin, Sérgio Henrique

doi:10.1002/masy.200651322

Cited by 10 publications

(9 citation statements)

References 8 publications

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“…PCL Triol is a biodegradable, semi-crystalline, aliphatic polyester, with low molecular weight and melting point which has been investigated to a great extent as a biomaterial as well as in drug delivery applications [32][33][34]. One reason for this is the degradation products of PCL being naturally occurring metabolites in the human body with sutures composed of PCL being approved by the US Food and Drug Administration (FDA) [35].…”

Section: Stereolithographic Printing Processmentioning

confidence: 99%

“…One reason for this is the degradation products of PCL being naturally occurring metabolites in the human body with sutures composed of PCL being approved by the US Food and Drug Administration (FDA) [35]. Further to this, low molecular weight PCL Triols have been investigated for their potential to act as plasticizers [33,36,37] with Kanis et al [34] indicating that it is the three hydroxyl groups present which allow it to act as a plasticizer. Furthermore, PCL Triols due to their nature do not possess photopolymerizable terminal groups and therefore cannot crosslink on their own which is why PCL derivatives have been developed [38][39][40].…”

Section: Stereolithographic Printing Processmentioning

confidence: 99%

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Additive Manufacturing of Personalized Pharmaceutical Dosage Forms via Stereolithography

et al. 2019

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The introduction of three-dimensional printing (3DP) has created exciting possibilities for the fabrication of dosage forms, paving the way for personalized medicine. In this study, oral dosage forms of two drug concentrations, namely 2.50% and 5.00%, were fabricated via stereolithography (SLA) using a novel photopolymerizable resin formulation based on a monomer mixture that, to date, has not been reported in the literature, with paracetamol and aspirin selected as model drugs. In order to produce the dosage forms, the ratio of poly(ethylene glycol) diacrylate (PEGDA) to poly(caprolactone) triol was varied with diphenyl(2,4,6-trimethylbenzoyl)phosphine oxide (Irgacure TPO) utilized as the photoinitiator. The fabrication of 28 dosages in one print process was possible and the printed dosage forms were characterized for their drug release properties. It was established that both drugs displayed a sustained release over a 24-h period. The physical properties were also investigated, illustrating that SLA affords accurate printing of dosages with some statistically significant differences observed from the targeted dimensional range, indicating an area for future process improvement. The work presented in this paper demonstrates that SLA has the ability to produce small, individualized batches which may be tailored to meet patients’ specific needs or provide for the localized production of pharmaceutical dosage forms.

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Section: Stereolithographic Printing Processmentioning

confidence: 99%

Section: Stereolithographic Printing Processmentioning

confidence: 99%

Additive Manufacturing of Personalized Pharmaceutical Dosage Forms via Stereolithography

et al. 2019

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“…Após adição da cipermetrina a blenda analisada demonstrou alteração relacionada ao P(3HB), como a elevação da T c de 43 para 55 °C, enquanto que para a PCL foi possível observar a T g em -43 °C, a T c em -12 °C e decréscimo na T m de 55 para 43 °C. A partir dos dados de entalpia de fusão (ΔH 0 m ) para o polímero 100% cristalino, ΔH 0 m = 142 J g -1 para o P(3HB) [41] e ΔH 0 m = 146 J g -1 para o PCL [14] o grau de cristalinidade (α c ) dos componentes na blenda foi calculado (α c %), através da razão de ΔH m pelo ΔH 0 m . A cristalinidade de um polímero pode ser considerada como um "arranjo ordenado", uma repetição regular de estruturas atômicas moleculares.…”

Section: Caracterização Das Microesferasunclassified

“…Entre os materiais que podem ser empregados na microencapsulação, encontram-se os polímeros obtidos de fontes naturais como os polihidroxialcanoatos e os poliésteres sintéticos como as policaprolactonas [12,13] . Os polihidroxialcanoatos são poliésteres termoplásticos sintetizados por várias bactérias a partir de fontes renováveis [14] . O polímero mais importante deste grupo é o poli(3-hidroxibutirato) -P(3HB), biodegradável [15] com ponto de fusão entre 173-180 °C e temperatura de transição vítrea entre -5 e 5 °C [16,17] .…”

Section: Introductionunclassified

Microencapsulação do pesticida cipermetrina em blendas de P(3HB/PCL): caracterização e ensaio de liberação in vitro

et al. 2016

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ResumoA aplicação de polímeros biodegradáveis para encapsular pesticidas é uma estratégia que permite, a partir de diferentes proporções entre os polímeros, modificar o perfil de liberação do agente. Este trabalho avaliou a liberação controlada do pesticida cipermetrina encapsulado em microesferas de blendas de P(3HB)/PCL (100/0, 0/100, 97/03, 95/05, 90/10, 80/20 e 70/30) obtidas pelo método de emulsificação-evaporação do solvente. As imagens de microscopia eletrônica de varredura revelam a forte influência da PCL na porosidade das microesferas. As análises de infravermelho mostraram a presença do pesticida em todas as composições de polímeros avaliadas. O ensaio de liberação de cipermetrina sugere que, no intervalo de 4 horas, o teor de cipermetrina liberada é dependente da composição das blendas utilizadas. As microesferas de PHB e blendas com menores teores de PCL, 97/03 e 95/05 liberaram 75% a 85% enquanto a composição 70/30 liberou 100% de cipermetrina. Palavras-chave: polímeros biodegradáveis, blendas, microencapsulação. AbstractThis work evaluated the controlled release of cypermethrin pesticide loaded in microspheres of P(3HB)/PCL blends obtained by emulsion-evaporation method. SEM analysis revealed a strong influence of PCL on the porosity of the microspheres. The infrared spectra showed the presence of pesticide in all polymer compositon evaluated. DSC curves showed that with higher content of PCL, decreased the crystallinity degree of polymers, resulting in a faster release of the pesticide. The release assay of cypermethrin suggests that within an interval of four hours the amount of pesticide released varies depending on the composition of the blends.

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“…Biodegradable microsphere‐based controlled release systems have been widely studied for pesticides and drug‐delivery devices 1. Polyhydroxyalkanoates are thermoplastic polyesters synthesized from bacteria after fermentation with renewable resources 2. The most important polymer is poly(3‐hydroxybutyrate) [P(3HB)], which has a melting point around 173–180°C and a glass‐transition temperature around −5 to 5°C 3…”

Section: Introductionmentioning

confidence: 99%

Biodegradable microspheres of poly(3‐hydroxybutyrate)/poly(ε‐caprolactone) loaded with malathion pesticide: Preparation, characterization, and in vitro controlled release testing

Suave

Dall’Agnol

Pezzin

et al. 2010

J of Applied Polymer Sci

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In this investigation, our aim was to evaluate the performance of a controlled release of malathion pesticide loaded in microspheres of pure polymers of poly(3-hydroxybutyrate) and poly(e-caprolactone) (PCL) and of blends of these polymers with compositions of 70/30, 80/20, 90/10, 95/5, and 97/3 w/w. Microspheres were obtained by an emulsion-evaporation method to load a model pesticide. Scanning electron microscopy and differential scanning calorimetry were used to characterize the effect of the pesticide on the morphology and particles size of the biodegradable microspheres. The interaction between the matrix and pesticide was determined by Fourier transform infrared spectroscopy. The test for controlled release was performed in an aqueous medium, and malathion was quantified by ultraviolet spectroscopy. The results show that the release of malathion was improved with the PCL content in the blends; this indicated the possibility of modulating the release of the pesticide in these biodegradable blends.

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Thermal Properties and Morphology of Poly(3‐Hydroxybutyrate‐co‐3‐Hydroxyvalerate) with Poly(Caprolactone Triol) Mixtures

Cited by 10 publications

References 8 publications

Additive Manufacturing of Personalized Pharmaceutical Dosage Forms via Stereolithography

Additive Manufacturing of Personalized Pharmaceutical Dosage Forms via Stereolithography

Microencapsulação do pesticida cipermetrina em blendas de P(3HB/PCL): caracterização e ensaio de liberação in vitro

Biodegradable microspheres of poly(3‐hydroxybutyrate)/poly(ε‐caprolactone) loaded with malathion pesticide: Preparation, characterization, and in vitro controlled release testing

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