Thermal Properties and Changes of Acoustic Parameters in an Egg White Phantom During Heating and Coagulation by High Intensity Focused Ultrasound

Divkovic, Gabriela Wilzbach; Liebler, Marko; Braun, Klaus; Dreyer, Thomas; Huber, Peter E.; Jenne, Jürgen

doi:10.1016/j.ultrasmedbio.2006.11.021

Cited by 52 publications

(42 citation statements)

References 14 publications

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“…The egg white phantom for HIFU is based on a polyacrylamide gel mixed with egg white, which is used as the temperature-sensitive indicator [7][8][9]. Having the same temperature-sensitive benefits to BSA, egg white is far less expensive.…”

Section: Egg White Phantom For Hifumentioning

confidence: 99%

“…In fundamental laboratory tests, tissue-mimicking phantoms, including BSA phantoms and egg white phantoms, have been recognized as useful tools for real-time visualization of HIFU-induced lesion evolution and calibration of HIFU transducers [5][6][7][8][9][10]. Some research groups have attempted to characterize the tissue-mimicking phantoms acoustically.…”

Section: Introductionmentioning

confidence: 99%

“…Among those, Lafon et al [5,6] measured the acoustic and optical properties of BSA-embedded polyacrylamide hydrogels as a function of BSA concentration and temperature; Takegami et al [7] presented the acoustic property characterization of polyacrylamide gels with different egg white concentrations. However, to date, very limited research has been conducted on the thermophysical characterization of tissue-mimicking phantoms for HIFU; except that Divkovic et al [8,9] reported on the thermal properties and temperature-dependent acoustic properties of egg white phantoms. But, in their study, the thermal conductivity and specific heat capacity were measured separately using the hot-wire method and conventional calorimetry, which are not available in most standard ultrasound labs.…”

Section: Introductionmentioning

confidence: 99%

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Simultaneous Measurement of Thermophysical Properties of Tissue-Mimicking Phantoms for High Intensity Focused Ultrasound (HIFU) Exposures

et al. 2012

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Tissue-mimicking phantoms, including bovine serum albumin phantoms and egg white phantoms, have been developed for, and in laboratory use for, realtime visualization of high intensity focused ultrasound-induced thermal coagulative necrosis since 2001. However, until now, very few data are available concerning their thermophysical properties. In this article, a step-wise transient plane source method has been used to determine the values of thermal conductivity, thermal diffusivity, and specific heat capacity of egg white phantoms with elevated egg white concentrations (0 v/v% to 40 v/v%, by 10 v/v% interval) at room temperature (∼20 • C). The measured thermophysical properties were close to previously reported values; the thermal conductivity and thermal diffusivity were linearly proportional to the egg white concentration within the investigation range, while the specific heat capacity decreased as the egg white concentration increased. Taking account of large differences between real experiment and ideal model, data variations within 20 % were accepted.Keywords Egg white phantom · High intensity focused ultrasound (HIFU) ·Step-wise transient plane source (TPS) method · Thermophysical properties ·

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Section: Egg White Phantom For Hifumentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Simultaneous Measurement of Thermophysical Properties of Tissue-Mimicking Phantoms for High Intensity Focused Ultrasound (HIFU) Exposures

et al. 2012

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“…The egg white phantom has been applied primarily to in vitro studies for the performance evaluation of therapeutic ultrasonic devices such as High Intensity Focused Ultrasound (HIFU) and hyperthermia [7][8][9][10][11][12][13][14].…”

Section: Introductionmentioning

confidence: 99%

Evaluation of Acoustic, Thermal, and Morphological Properties in the Egg White Phantom

Kim¹,

Kim²,

Moon³

et al. 2015

Journal of Biomedical Engineering Research

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Abstract:The egg white phantom is a thermal lesion visualization phantom able to illustrate a thermal lesion. It is often used to evaluate the performance of HIFU and is less expensive than the BSA phantom. This study determined the optimal phantom composition for evaluated therapeutic ultrasound machines by varying the egg white concentration in the egg white phantom and demonstrated its utility as a therapeutic ultrasound phantom. The egg white phantom at varying egg white concentrations (10-40% in 10% intervals) was fabricated, and its thermal properties and acoustic properties were assessed. In addition, the size and shape of the formed lesion were compared between the egg white phantom and bovine liver tissue according to the electrical power. The results showed that 30% egg white phantom was optimal for the performance evaluation due to its thermal and acoustic properties. The generated thermal lesions formed sequentially as a cigar, ellipse, tadpole, and cone shapes according to the electrical power; a similar tendency was observed in the liver tissue. Hence, we conclude that the egg white phantom will prove useful in quantitatively evaluating the thermal effects of therapeutic ultrasound.

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“…RECENT IMPROVEMENTS IN high-intensity focused ultrasound (HIFU) technology have revealed its potential as a noninvasive surgical tool in many clinical settings (1)(2)(3)(4)(5)(6)(7). Of the many tools available for monitoring HIFU treatment, magnetic resonance imaging (MRI) has proven to be a practical tool for this purpose.…”

mentioning

confidence: 99%

Proton resonance frequency shift‐weighted imaging for monitoring MR‐guided high‐intensity focused ultrasound transmissions

Chen

Huang

Peng

et al. 2011

Magnetic Resonance Imaging

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Purpose: To combine temperature-related information of phase images and magnitude images acquired from an MR spoiled gradient echo sequence using a postprocessing method referred to as PRF-shift-weighted imaging (PRFSWI). Materials and Methods:Phase images are capable of detecting shifts in proton resonance frequency (PRF) caused by local changes in temperature. Magnitude images provide anatomical information for treatment planning and positioning as well as temperature-related contrast. We used PRFSWI to produce a phase-mask and performed multiplication on the magnitude image to increase temperature-related contrast.Results: Through MRI-guided focused ultrasound (MRIg-FUS) experiments (both ex vivo and in vivo), we determined that PRFSWI is capable of enhancing the contrast of a heated area even in the initial stages of transmitting high-intensity focused ultrasound energy. Conclusion:The PRFSWI images are sensitive to changes in temperature and display the heated spot directly in the magnitude images. Although the images do not provide quantitative data related to temperature, this method could be used as a complement to the phase temperature mapping method in the real-time monitoring of MRIgFUS experiments.

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Thermal Properties and Changes of Acoustic Parameters in an Egg White Phantom During Heating and Coagulation by High Intensity Focused Ultrasound

Cited by 52 publications

References 14 publications

Simultaneous Measurement of Thermophysical Properties of Tissue-Mimicking Phantoms for High Intensity Focused Ultrasound (HIFU) Exposures

Simultaneous Measurement of Thermophysical Properties of Tissue-Mimicking Phantoms for High Intensity Focused Ultrasound (HIFU) Exposures

Evaluation of Acoustic, Thermal, and Morphological Properties in the Egg White Phantom

Proton resonance frequency shift‐weighted imaging for monitoring MR‐guided high‐intensity focused ultrasound transmissions

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