Thermal nanoimprint lithography of sodium hyaluronate solutions with gas permeable inorganic hybrid mold for cosmetic and pharmaceutical applications

Yamagishi, Rio; Miura, Sayaka; Yasuda, Kaori; Sugino, Naoto; Kameda, Takao; Kawano, Yuki; Yokoyama, Yoshihiko; Takei, Satoshi

doi:10.35848/1882-0786/ac5ba6

Cited by 9 publications

(6 citation statements)

References 31 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…A sol-gel copolymer (Fig. 2, a) with four components, namely, 40 wt% 3-(acryloyloxy) propyl trimethoxysilane, 35 wt% methyltrimethoxysilane, 15 wt% tetraethyl titanate, and 10 wt% tetraethoxysilane, was synthesized by using sol-gel polymerization [30][31][32]. The 87 wt% sol-gel copolymer was added with 2,4,6,8-tetramethyl-2,4,6,8-tetravinylcyclotetrasiloxane (T2523: Tokyo Chemical Industry) (Fig.…”

Section: Methodsmentioning

confidence: 99%

Nanoimprint Lithography and Microinjection Molding Using Gas-Permeable Hybrid Mold for Antibacterial Nanostructures

Miura,

Yamagishi,

Sugino

et al. 2023

J. Photopol. Sci. Technol.

Self Cite

View full text Add to dashboard Cite

Biomimetic antibacterial nanostructures with a height of approximately 310 nm and a bottom diameter of approximately 240 nm were fabricated by microinjection molding for practical mass production in the fields of biology, electronic engineering, and life science. The gas-permeable hybrid mold fabricated by nanoimprint lithography was used as the mold for microinjection molding to improve the incomplete filling and molding defects caused by gas entrainment in cavities during microinjection molding. One same mold could be used repeatedly without cleaning for 200 injection molding cycles. Antibacterial activity evaluation showed that that the antibacterial activity of the fabricated biomimetic antibacterial nanostructures was 15% greater than that of a flat surface. This work establishes the advanced processing technology of high-resolution nanostructures by microinjection molding with the gas-permeable hybrid mold.

show abstract

Section: Methodsmentioning

confidence: 99%

Nanoimprint Lithography and Microinjection Molding Using Gas-Permeable Hybrid Mold for Antibacterial Nanostructures

Miura,

Yamagishi,

Sugino

et al. 2023

J. Photopol. Sci. Technol.

Self Cite

View full text Add to dashboard Cite

show abstract

“…Prior studies have underscored the molding limitations associated with hya acid microneedles when employing quartz or metal molds with gas impermeability limitations include molding defects stemming from the high interfacial tension b the solution and mold as well as the entrapment of bubbles at the needle tips [50,51 Prior studies have underscored the molding limitations associated with hyaluronic acid microneedles when employing quartz or metal molds with gas impermeability. These limitations include molding defects stemming from the high interfacial tension between the solution and mold as well as the entrapment of bubbles at the needle tips [50,51]. Conversely, the utilization of the UV-curing TiO 2 -SiO 2 gas-permeable mold ameliorates these issues by expelling bubbles through its porous structure and enhancing the overall mold quality.…”

Section: Patterning Of Sodium Hyaluronate Ultrafine Microneedles Usin...mentioning

confidence: 99%

Fabrication Technology of Self-Dissolving Sodium Hyaluronate Gels Ultrafine Microneedles for Medical Applications with UV-Curing Gas-Permeable Mold

Yamagishi,

Miura,

Yabu

et al. 2024

Gels

Self Cite

View full text Add to dashboard Cite

Microneedles are of great interest in diverse fields, including cosmetics, drug delivery systems, chromatography, and biological sensing for disease diagnosis. Self-dissolving ultrafine microneedles of pure sodium hyaluronate hydrogels were fabricated using a UV-curing TiO2-SiO2 gas-permeable mold polymerized by sol-gel hydrolysis reactions in nanoimprint lithography processes under refrigeration at 5 °C, where thermal decomposition of microneedle components can be avoided. The moldability, strength, and dissolution behavior of sodium hyaluronate hydrogels with different molecular weights were compared to evaluate the suitability of ultrafine microneedles with a bottom diameter of 40 μm and a height of 80 μm. The appropriate molecular weight range and formulation of pure sodium hyaluronate hydrogels were found to control the dissolution behavior of self-dissolving ultrafine microneedles while maintaining the moldability and strength of the microneedles. This fabrication technology of ultrafine microneedles expands their possibilities as a next-generation technique for bioactive gels for controlling the blood levels of drugs and avoiding pain during administration.

show abstract

“…The UV nanoimprint processes were performed in two steps: imprinting the gas-permeable template using a quartz master template and imprinting the UV-curable material using our developing gaspermeable template [48][49][50] [51].…”

Section: Ultraviolet Nanoimprint Lithographymentioning

confidence: 99%

Ultraviolet-curable Material with High Fluorine Content for Biomimetic Functional Structures Achieved by Nanoimprint Lithography with Gas-permeable Template for Life Science and Electronic Applications

Yamagishi,

Miura,

Ando

et al. 2023

J. Photopol. Sci. Technol.

Self Cite

View full text Add to dashboard Cite

Fluorine materials exhibit excellent properties, such as high water repellency, low adhesion, and chemical resistance, owing to their low surface energy. They also exhibit high thermal and oxidation stability owing to the strength of the C-F bonds. Recently, in the field of life science, further improvement of the low adherence and antifouling properties of biological substances and microorganisms by imparting surface properties to fluorine materials through pattern fabrication technology has attracted considerable attention. However, fluorine materials exhibit high thermal expansion and contraction, making it difficult to apply fabrication methods, such as injection molding and hot embossing. Conventional focused ion beam and laser processing are difficult for further pattern fabrication. Here, an ultraviolet (UV)-curable material with a high fluorine content (44wt%) was created, and the pattern fabrication of 80-nm line structures was performed on the material by UV nanoimprint lithography using the gas-permeable template that can permeate the gas entrained during pressurization. The water contact angle was 127.3°, with 129.7° being the most favorable, achieved by a combination of the water-repellency characteristics of the UV-curable material with high fluorine content and fine line patterning in the nanometer range. We discovered the possibility of creating surface functions on short-chain perfluoroalkyl sulfonate (PFAS) substitutes with a relatively low impact on the environment and human body by establishing a pattern fabrication method for long-chain PFAS, which is more difficult to pattern fabricate, as a preliminary experiment.

show abstract

Thermal nanoimprint lithography of sodium hyaluronate solutions with gas permeable inorganic hybrid mold for cosmetic and pharmaceutical applications

Cited by 9 publications

References 31 publications

Nanoimprint Lithography and Microinjection Molding Using Gas-Permeable Hybrid Mold for Antibacterial Nanostructures

Nanoimprint Lithography and Microinjection Molding Using Gas-Permeable Hybrid Mold for Antibacterial Nanostructures

Fabrication Technology of Self-Dissolving Sodium Hyaluronate Gels Ultrafine Microneedles for Medical Applications with UV-Curing Gas-Permeable Mold

Ultraviolet-curable Material with High Fluorine Content for Biomimetic Functional Structures Achieved by Nanoimprint Lithography with Gas-permeable Template for Life Science and Electronic Applications

Contact Info

Product

Resources

About