Thermal Magnetic Field Activated Propolis Release From Liquid Crystalline System Based on Magnetic Nanoparticles

Toledo, Lucas de Alcântara Sica de; Rosseto, Hélen Cássia; Santos, Rafaela Said dos; Spizzo, F.; Bianco, L. Del; Montanha, Maiara Camotti; Esposito, Elisabetta; Kimura, Elza; Mendonca, Patricia; Svidzinski, Terezinha Inez Estivalet; Cortesi, Rita; Bruschi, Marcos Luciano

doi:10.1208/s12249-018-1163-4

Cited by 25 publications

(21 citation statements)

References 79 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…In general, iron oxides were shown great interest due to their nanosized form, and these crystalline polymorphs can be suitable for specific pharmaceutical applications. They can generally be synthesized as particulate materials displaying sizes less than 100 nm that can suffer the influence of an external magnetic field and can, thus, be manipulated [11,12,16,27,29,30].…”

Section: Iron Oxides and Nanoparticlesmentioning

confidence: 99%

“…Their emulsifying and adhesive properties enable the preparation of hydrogel structures. The hydrogen bonds between the polymer chains can involve the IOMNPs avoiding the agglomeration of nanoparticles [6,29].…”

Section: Drug Deliverymentioning

confidence: 99%

“…When IOMNPs are subjected to an altering current (AC), the magnetic field randomly flips the magnetization direction between the parallel and antiparallel orientations [1,6,29,32]. Magnetic energy can be transmitted to the nanoparticles in the form of heat, and this property can be used in vivo to raise the temperature of tumor tissues.…”

Section: Hyperthermiamentioning

confidence: 99%

“…Antimicrobial resistance is an old and huge concern for public health systems, having grown rapidly in recent times, spreading the preoccupation to economics [92,[95][96][97]. The use of gold, silver, aluminum, and iron oxide as antimicrobials was previously proven [29,[98][99][100][101][102].…”

Section: Antimicrobial Activitymentioning

confidence: 99%

“…IOMNPs may act as actual antimicrobial agents, or even in a synergistic way with antimicrobial agents [29,98]. A dosage form containing IOMNPs synergically mixed with streptomycin was already developed; it was prepared in a chitosan-based structure.…”

Section: Antimicrobial Activitymentioning

confidence: 99%

See 4 more Smart Citations

Pharmaceutical Applications of Iron-Oxide Magnetic Nanoparticles

Bruschi

Toledo

2019

Magnetochemistry

Self Cite

View full text Add to dashboard Cite

Advances of nanotechnology led to the development of nanoparticulate systems with many advantages due to their unique physicochemical properties. The use of iron-oxide magnetic nanoparticles (IOMNPs) in pharmaceutical areas increased in the last few decades. This article reviews the conceptual information about iron oxides, magnetic nanoparticles, methods of IOMNP synthesis, properties useful for pharmaceutical applications, advantages and disadvantages, strategies for nanoparticle assemblies, and uses in the production of drug delivery, hyperthermia, theranostics, photodynamic therapy, and as an antimicrobial. The encapsulation, coating, or dispersion of IOMNPs with biocompatible material(s) can avoid the aggregation, biodegradation, and alterations from the original state and also enable entrapping the bioactive agent on the particle via adsorption or covalent attachment. IOMNPs show great potential for target drug delivery, improving the therapy as a consequence of a higher drug effect using lower concentrations, thus reducing side effects and toxicity. Different methodologies allow IOMNP synthesis, resulting in different structures, sizes, dispersions, and surface modifications. These advantages support their utilization in pharmaceutical applications, and getting suitable drug release control on the target tissues could be beneficial in several clinical situations, such as infections, inflammations, and cancer. However, more toxicological clinical investigations about IOMNPs are necessary.

show abstract

Section: Iron Oxides and Nanoparticlesmentioning

confidence: 99%

Section: Drug Deliverymentioning

confidence: 99%

Section: Hyperthermiamentioning

confidence: 99%

Section: Antimicrobial Activitymentioning

confidence: 99%

Section: Antimicrobial Activitymentioning

confidence: 99%

See 3 more Smart Citations

Pharmaceutical Applications of Iron-Oxide Magnetic Nanoparticles

Bruschi

Toledo

2019

Magnetochemistry

Self Cite

View full text Add to dashboard Cite

show abstract

From propolis to nanopropolis: An exemplary journey and a paradigm shift of a resinous substance produced by bees

Javed

Mangla

Ahsan

2022

Phytotherapy Research

View full text Add to dashboard Cite

Propolis, a natural resinous mixture produced by honey bees is poised with diverse biological activities. Owing to the presence of flavonoids, phenolic acids, terpenes, and sesquiterpenes, propolis has garnered versatile applications in pharmaceutical industry. The biopharmaceutical issues associated with propolis often beset its use as being too hydrophobic in nature; it is not absorbed in the body well. To combat the problem, various nanotechnological approaches for the development of novel drug delivery systems are generally applied to improve its bioavailability. This paradigm shift and transition of conventional propolis to nanopropolis are evident from the literature wherein a multitude of studies are available on nanopropolis with improved bioavailability profile. These approaches include preparation of gold nanoparticles, silver nanoparticles, magnetic nanoparticles, liposomes, liquid crystalline formulations, solid lipid nanoparticles, mesoporous silica nanoparticles, etc. Nanopropolis has further been explored to assess the potential benefits of propolis for the development of futuristic useful products such as sunscreens, creams, mouthwashes, toothpastes, and nutritional supplements with improved solubility, bioavailability, and penetration profiles. However, more high-quality clinical studies assessing the effects of propolis either alone or in combination with synthetic drugs as well as natural products are warranted and its safety needs to be firmly established.

show abstract

Current status and future of delivery systems for prevention and treatment of infections in the oral cavity

Şenel

Özdoğan²,

Akca

2021

Drug Deliv. and Transl. Res.

View full text Add to dashboard Cite

Oral health reflects the general health, and it is fundamental to well-being and quality of life. An infection in the oral cavity can be associated with serious complications in human health. Local therapy of these infections offers many advantages over systemic drug administration, targeting directly to the diseased area while minimizing systemic side effects. Specialized drug delivery systems into the oral cavity have to be designed in such a fashion that they resist to the aqueous environment that is constantly bathed in saliva and subject to mechanical forces. Additionally, a prolonged release of drug should also be provided, which would enhance the efficacy and also decrease the repeated dosing. This review is aimed to summarize the current most relevant findings related to local drug delivery of various drug groups for prevention and treatment of infections (viral, bacterial, fungal) and infection-related manifestations in the oral cavity. Current therapeutic challenges in regard to effective local drug delivery systems will be discussed, and the recent approaches to overcome these obstacles will be reviewed. Finally, future prospects will be overviewed to promote novel strategies that can be implemented in clinical management for prevention and treatment of oral infections.

show abstract

Thermal Magnetic Field Activated Propolis Release From Liquid Crystalline System Based on Magnetic Nanoparticles

Cited by 25 publications

References 79 publications

Pharmaceutical Applications of Iron-Oxide Magnetic Nanoparticles

Pharmaceutical Applications of Iron-Oxide Magnetic Nanoparticles

From propolis to nanopropolis: An exemplary journey and a paradigm shift of a resinous substance produced by bees

Current status and future of delivery systems for prevention and treatment of infections in the oral cavity

Contact Info

Product

Resources

About