Thermal investigation on hydrated co-amorphous systems of nicotinamide and prilocaine

Anti-plasticizing effect of water on prilocaine and lidocaine – the role of the hydrogen bonding pattern

“…As shown in Table 1, the experimental T g s of PRL and LID with ethanol and ethylene glycol were higher than the theoretical T g s of the solvated drugs. These findings contradict the assumptions that ethanol and ethylene glycol acted purely as plasticizers for PRL and LID, 37 but rather indicate a certain anti-plasticizing potential. However, this anti-plasticizing potential did not result in an increase of the T g s of PRL and LID, but rather in a decrease that is less than theoretically predicted.…”