“…Therefore, the UCNPs can significantly decrease thermal loading and minimize the tissue damage. − The use of UCNPs for the biological appliations has received increasing attention. However, as an optimal biological probe, the high UCL efficiency and multicolor UCL output are simultaneously required for UCNPs, which is still a challenge. , It is well-known that the UCL efficiency is related to particle size, crystallite phase, dopant ions, and host system. − In addition, size, shape, and phase of UCNPs have also great influence on their luminescence and biological application. − Compared with the sulfide hosts and fluoride hosts, oxide systems were addressed as the efficiency UCL hosts, owing to their high chemical stability and low toxicity. − …”