Thermal inactivation scaling applied for SARS-CoV-2

Seifer, Shahar; Elbaum, Michael

doi:10.1016/j.bpj.2020.11.2259

Cited by 8 publications

(6 citation statements)

References 34 publications

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“…For the SARS-CoV-2 in cell culture, 99.99% inactivation was achieved after heating at 56 °C for 15 min, showing that it was compatible with the theoretical model (3) [ 48 ].

…”

Section: Discussionsupporting

confidence: 52%

Inactivation of viruses on surfaces by infrared techniques

Karaböce

Saban²,

Böyük³

et al. 2022

International Journal of Thermal Sciences

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“…For the SARS-CoV-2 in cell culture, 99.99% inactivation was achieved after heating at 56 °C for 15 min, showing that it was compatible with the theoretical model (3) [ 48 ].

…”

Section: Discussionsupporting

confidence: 52%

Inactivation of viruses on surfaces by infrared techniques

Karaböce

Saban²,

Böyük³

et al. 2022

International Journal of Thermal Sciences

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“…First, the temperature-induced denaturation leads to the destruction of the protein spike and virus at high temperatures. 56,57 Second, at extremely high temperatures, a reduction of hydrophobic interaction causes fewer effects on the virus.…”

Section: Interaction Of Planar Fiber With Sars-cov-2 Virusmentioning

confidence: 99%

Effects of surface charge and environmental factors on the electrostatic interaction of fiber with virus-like particle: A case of coronavirus

et al. 2021

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We propose a theoretical model to elucidate intermolecular electrostatic interactions between a virus and a substrate. Our model treats the virus as a homogeneous particle having surface charge and the polymer fiber of the respirator as a charged plane. Electric potentials surrounding the virus and fiber are influenced by the surface charge distribution of the virus. We use Poisson–Boltzmann equations to calculate electric potentials. Then, Derjaguin’s approximation and a linear superposition of the potential function are extended to determine the electrostatic force. In this work, we apply this model for coronavirus or SARS-CoV-2 case and numerical results quantitatively agree with prior simulation. We find that the influence of fiber’s potential on the surface charge of the virus is important and is considered in interaction calculations to obtain better accuracy. The electrostatic interaction significantly decays with increasing separation distance, and this curve becomes steeper when adding more salt. Although the interaction force increases with heating, one can observe the repulsive–attractive transition when the environment is acidic.

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Section: Particle-like Virus With Modified Charge Surfacementioning

confidence: 99%

Effects of surface charge and environmental factors on the electrostatic interaction of fiber with virus-like particle: A case of coronavirus

Dung¹,

Phan²,

Nguyen³

et al. 2021

Preprint

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We propose a theoretical model to elucidate intermolecular electrostatic interactions between a virus and a substrate. Our model treats the virus as a homogeneous particle having surface charge and the polymer fiber of the respirator as a charged plane. Electric potentials surrounding the virus and fiber are influenced by the surface charge distribution of the virus. We use Poisson-Boltzmann equations to calculate electric potentials. Then, Derjaguin's approximation and a linear superposition of the potential function are extended to determine the electrostatic force. In this work, we apply this model for coronavirus or SARS-CoV-2 case and numerical results quantitatively agree with prior simulation. We find that the influence of fiber's potential on the surface charge of the virus is important and is considered in interaction calculations to obtain better accuracy. The electrostatic interaction significantly decays with increasing separation distance, and this curve becomes steeper when adding more salt. Although the interaction force increases with heating, one can observe the repulsive-attractive transition when the environment is acidic.

show abstract

Thermal inactivation scaling applied for SARS-CoV-2

Cited by 8 publications

References 34 publications

Inactivation of viruses on surfaces by infrared techniques

Inactivation of viruses on surfaces by infrared techniques

Effects of surface charge and environmental factors on the electrostatic interaction of fiber with virus-like particle: A case of coronavirus

Effects of surface charge and environmental factors on the electrostatic interaction of fiber with virus-like particle: A case of coronavirus

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