Thermal immuno-nanomedicine in cancer

Yang, Zhe; Gao, Di; Zhao, Jing; Yang, Gaojie; Guo, Ming; Wang, Ying; Ren, Xuechun; Kim, Jong Seung; Jin, Lin; Tian, Zhongmin; Zhang, Xingcai

doi:10.1038/s41571-022-00717-y

Cited by 98 publications

(54 citation statements)

References 249 publications

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“…In addition to 1 3 promoting tumor angiogenesis and metastasis, the TME could induce treatment resistance and failure. Therefore, to manage the release of nucleic acid drugs used in gene therapy, the TME is frequently utilized as a hallmark for cancer treatment, while light, thermo, US, MF, etc., [69][70][71][72] are the mainly artificial exogenous stimuli that are applied for developing various GDNCs in gene therapy. By utilizing these exogenous stimuli, timely, localized, and quantitative gene release might be achieved.…”

Section: Various Stimulimentioning

confidence: 99%

Stimuli-Responsive Gene Delivery Nanocarriers for Cancer Therapy

Zhang

Kuang

et al. 2023

Nano-Micro Lett.

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Gene therapy provides a promising approach in treating cancers with high efficacy and selectivity and few adverse effects. Currently, the development of functional vectors with safety and effectiveness is the intense focus for improving the delivery of nucleic acid drugs for gene therapy. For this purpose, stimuli-responsive nanocarriers displayed strong potential in improving the overall efficiencies of gene therapy and reducing adverse effects via effective protection, prolonged blood circulation, specific tumor accumulation, and controlled release profile of nucleic acid drugs. Besides, synergistic therapy could be achieved when combined with other therapeutic regimens. This review summarizes recent advances in various stimuli-responsive nanocarriers for gene delivery. Particularly, the nanocarriers responding to endogenous stimuli including pH, reactive oxygen species, glutathione, and enzyme, etc., and exogenous stimuli including light, thermo, ultrasound, magnetic field, etc., are introduced. Finally, the future challenges and prospects of stimuli-responsive gene delivery nanocarriers toward potential clinical translation are well discussed. The major objective of this review is to present the biomedical potential of stimuli-responsive gene delivery nanocarriers for cancer therapy and provide guidance for developing novel nanoplatforms that are clinically applicable.

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Section: Various Stimulimentioning

confidence: 99%

Stimuli-Responsive Gene Delivery Nanocarriers for Cancer Therapy

Zhang

Kuang

et al. 2023

Nano-Micro Lett.

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“…From these results, hyperthermia has been suggested as a unique non-invasive cancer theranostics with localized thermal effects and without side effects to healthy tissues or cells. Many light sources have been suggested, from radiofrequency to laser are applied to stimulate the irradiation in gold nanostructures for phototherapy [ 67 , 68 , 69 , 70 , 71 , 72 ].…”

Section: Gold Nanostructures In Nanomedicinementioning

confidence: 99%

Recent Progress of Gold-Based Nanostructures towards Future Emblem of Photo-Triggered Cancer Theranostics: A Special Focus on Combinatorial Phototherapies

Sekar¹,

Basavegowda

Thathapudi

et al. 2023

Pharmaceutics

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Cancer is one of the most dangerous health problems in the millennium and it is the third foremost human cause of death in the universe. Traditional cancer treatments face several disadvantages and cannot often afford adequate outcomes. It has been exhibited that the outcome of several therapies can be improved when associated with nanostructures. In addition, a modern tendency is being developed in cancer therapy to convert single-modal into multi-modal therapies with the help of existing various nanostructures. Among them, gold is the most successful nanostructure for biomedical applications due to its flexibility in preparation, stabilization, surface modifications, less cytotoxicity, and ease of bio-detection. In the past few decades, gold-based nanomaterials rule cancer treatment applications, currently, gold nanostructures were the leading nanomaterials for synergetic cancer therapies. In this review article, the synthesis, stabilization, and optical properties of gold nanostructures have been discussed. Then, the surface modifications and targeting mechanisms of gold nanomaterials will be described. Recent signs of progress in the application of gold nanomaterials for synergetic cancer therapies such as photodynamic and photo-thermal therapies in combination with other common interventions such as radiotherapy, chemotherapy, and will be reviewed. Also, a summary of the pharmacokinetics of gold nanostructures will be delivered. Finally, the challenges and outlooks of the gold nanostructures in the clinics for applications in cancer treatments are debated.

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“…Nanomedicine has been used for cancer diagnosis and therapy via merging the physical, biological, chemical and digital technologies together (Ahmad et al, 2023;Li et al, 2023). In recent years, nanomedicine has exhibited a potent effect in immunotherapy for cancer patients (Irvine and Dane, 2020;Guo et al, 2022b;Wang et al, 2022b;Yang et al, 2023).…”

Section: Nanomedicinementioning

confidence: 99%

Nanoparticles overcome adaptive immune resistance and enhance immunotherapy via targeting tumor microenvironment in lung cancer

et al. 2023

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Lung cancer is one of the common malignant cancers worldwide. Immune checkpoint inhibitor (ICI) therapy has improved survival of lung cancer patients. However, ICI therapy leads to adaptive immune resistance and displays resistance to PD-1/PD-L1 blockade in lung cancer, leading to less immune response of lung cancer patients. Tumor microenvironment (TME) is an integral tumor microenvironment, which is involved in immunotherapy resistance. Nanomedicine has been used to enhance the immunotherapy in lung cancer. In this review article, we described the association between TME and immunotherapy in lung cancer. We also highlighted the importance of TME in immunotherapy in lung cancer. Moreover, we discussed how nanoparticles are involved in regulation of TME to improve the efficacy of immunotherapy, including Nanomedicine SGT-53, AZD1080, Nanomodulator NRF2, Cisplatin nanoparticles, Au@PG, DPAICP@ME, SPIO NP@M-P, NBTXR3 nanoparticles, ARAC nanoparticles, Nano-DOX, MS NPs, Nab-paclitaxel, GNPs-hPD-L1 siRNA. Furthermore, we concluded that targeting TME by nanoparticles could be helpful to overcome resistance to PD-1/PD-L1 blockade in lung cancer.

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Thermal immuno-nanomedicine in cancer

Cited by 98 publications

References 249 publications

Stimuli-Responsive Gene Delivery Nanocarriers for Cancer Therapy

Stimuli-Responsive Gene Delivery Nanocarriers for Cancer Therapy

Recent Progress of Gold-Based Nanostructures towards Future Emblem of Photo-Triggered Cancer Theranostics: A Special Focus on Combinatorial Phototherapies

Nanoparticles overcome adaptive immune resistance and enhance immunotherapy via targeting tumor microenvironment in lung cancer

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