Thermal grill‐evoked sensations of heat correlate with cold pain threshold and are enhanced by menthol and cinnamaldehyde

Averbeck, Beate; Rucker, F.; Laubender, Rüdiger P.; Carr, Richard W.

doi:10.1002/j.1532-2149.2012.00239.x

Cited by 20 publications

(27 citation statements)

References 46 publications

(75 reference statements)

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“…As for the L-menthol containing solution this is well in line with previous results. 4,8,63 However, CA, herein found to induce cold hyperalgesia has previously been found to produce contradictory CPT results including cold hypoalgesia, cold hyperalgesia or simply no significant alterations. 3,39,40,43,50 Cold pain sensation is hypothesized to rely on a mutual nociceptive pathway for both nociceptive heat and cold producing a M A N U S C R I P T…”

Section: Thermal Thresholdsmentioning

confidence: 88%

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High-Concentration L-Menthol Exhibits Counter-Irritancy to Neurogenic Inflammation, Thermal and Mechanical Hyperalgesia Caused by Trans-cinnamaldehyde

Andersen

Gazerani

Arendt-Nielsen

2016

The Journal of Pain

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Drugs interacting with transient receptor potential channels are of great therapeutic potential. In the present study we established cutaneous pain and hyperalgesia using the TRPA1 agonist CA. Subsequently, we showed that the frequently used topical counterirritant and TRPM8 agonist, L-menthol, decreased evoked pain, hyperalgesia, and inflammation, indicating direct and indirect antinociceptive mechanisms.

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Section: Thermal Thresholdsmentioning

confidence: 88%

“…Ethanol was chosen as a vehicle because of 1) its ability to dissolve a high concentration of L-menthol, 2) its low toxicity for an organic solvent, 3) its marginal somatosensory sensory effects and 4) the precedence of using it in literature. 3,4,39,40,43 …”

Section: Application Of Ca and L-mentholmentioning

confidence: 99%

High-Concentration L-Menthol Exhibits Counter-Irritancy to Neurogenic Inflammation, Thermal and Mechanical Hyperalgesia Caused by Trans-cinnamaldehyde

Andersen

Gazerani

Arendt-Nielsen

2016

The Journal of Pain

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“…In addition, we used both sub-domains of sensory tests and additional global scores for the analyses. Note that clinical populations evince threshold changes in their response to heat and cold pain (Valmunen et al, 2009 ; Averbeck et al, 2013 ; Ahmad et al, 2014 ) and in their sensitivity to smell and taste (Mattes et al, 1995 ; Grossmann et al, 2005 ; Iranzo et al, 2013 ). On the assumption that heat/cold pain perception and smell/taste identification are substantially different processes, we analyzed them additionally to the global scores for each sensation.…”

Section: Methodsmentioning

confidence: 99%

Disentangling interoception: insights from focal strokes affecting the perception of external and internal milieus

et al. 2015

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Interoception is the moment-to-moment sensing of the physiological condition of the body. The multimodal sources of interoception can be classified into two different streams of afferents: an internal pathway of signals arising from core structures (i.e., heart, blood vessels, and bronchi) and an external pathway of body-mapped sensations (i.e., chemosensation and pain) arising from peripersonal space. This study examines differential processing along these streams within the insular cortex (IC) and their subcortical tracts connecting frontotemporal networks. Two rare patients presenting focal lesions of the IC (insular lesion, IL) or its subcortical tracts (subcortical lesion, SL) were tested. Internally generated interoceptive streams were assessed through a heartbeat detection (HBD) task, while those externally triggered were tapped via taste, smell, and pain recognition tasks. A differential pattern was observed. The IC patient showed impaired internal signal processing while the SL patient exhibited external perception deficits. Such selective deficits remained even when comparing each patient with a group of healthy controls and a group of brain-damaged patients. These outcomes suggest the existence of distinguishable interoceptive streams. Results are discussed in relation with neuroanatomical substrates, involving a fronto-insulo-temporal network for interoceptive and cognitive contextual integration.

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“…3 It is well known that low concentrations of topical L-menthol create an innocuous cooling sensation 19 ; however, when high concentrations are used, 11,47 cold hypersensitivity develops. 5,8,20 The transient receptor potential channel subfamily M (melastin) member 8 (TRPM8) is located on C-and Ad-fibers and is a key player in the development of L-menthol-induced cold allodynia. 32 This channel is activated by temperatures ,25˚C and L-menthol.…”

Section: Introductionmentioning

confidence: 99%

Cold and L-menthol-induced sensitization in healthy volunteers—a cold hypersensitivity analogue to the heat/capsaicin model

Andersen

Poulsen²,

Uchida³

et al. 2015

Pain

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Topical high-concentration L-menthol is the only established human experimental pain model to study mechanisms underlying cold hyperalgesia. We aimed at investigating the combinatorial effect of cold stimuli and topical L-menthol on cold pain and secondary mechanical hyperalgesia. Analogue to the heat-capsaicin model on skin sensitization, we proposed that cold/menthol enhances or prolong L-menthol-evoked sensitization. Topical 40% L-menthol or vehicle was applied (20 minutes) on the volar forearms of 20 healthy females and males (age, 28.7 ± 0.6 years). Cold stimulation of 5°C for 5 minutes was then applied to the treated area 3 times with 40-minute intervals. Cold detection threshold and pain, mechanical hyperalgesia (pinprick), static and dynamic mechanical allodynia (von Frey and brush), skin blood flow (laser speckle), and temperature (thermocamera) were assessed. Cold detection threshold and cold pain threshold (CPT) increased after L-menthol and remained high after the cold rekindling cycles (P < 0.001). L-menthol evoked secondary hyperalgesia to pinprick (P < 0.001) particularly in females (P < 0.05) and also induced secondary allodynia to von Frey and brush (P < 0.001). Application of cold stimuli kept these areas enlarged with a higher response in females to brush after the third cold cycle (P < 0.05). Skin blood flow increased after L-menthol (P < 0.001) and stayed stable after cold cycles. Repeated application of cold on skin treated by L-menthol facilitated and prolonged L-menthol-induced cold pain and hyperalgesia. This model may prove beneficial for testing analgesic compounds when a sufficient duration of time is needed to see drug effects on CPT or mechanical hypersensitivity.

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Thermal grill‐evoked sensations of heat correlate with cold pain threshold and are enhanced by menthol and cinnamaldehyde

Cited by 20 publications

References 46 publications

High-Concentration L-Menthol Exhibits Counter-Irritancy to Neurogenic Inflammation, Thermal and Mechanical Hyperalgesia Caused by Trans-cinnamaldehyde

High-Concentration L-Menthol Exhibits Counter-Irritancy to Neurogenic Inflammation, Thermal and Mechanical Hyperalgesia Caused by Trans-cinnamaldehyde

Disentangling interoception: insights from focal strokes affecting the perception of external and internal milieus

Cold and L-menthol-induced sensitization in healthy volunteers—a cold hypersensitivity analogue to the heat/capsaicin model

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