Thermal gelation of cellulose based suspensions

Viitanen, Leevi; Miranda-Valdez, Isaac Yair; Koivisto, Juha; Puisto, Antti; Alava, Mikko J.

doi:10.1007/s10570-023-05150-7

Cited by 3 publications

(2 citation statements)

References 37 publications

(58 reference statements)

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“…The latter might be related with the higher solubility of lactose at 40 °C, reducing the flow resistance, in comparison with 25 °C [ 34 ]. In the case of F1 and F4, it might be related to the increase in viscosity due to changes in cellulose network [ 35 ].…”

Section: Resultsmentioning

confidence: 99%

“…The latter might be related with the higher solubility of lactose at 40 • C, reducing the flow resistance, in comparison with 25 • C [34]. In the case of F1 and F4, it might be related to the increase in viscosity due to changes in cellulose network [35]. For evaluating the influence of printing speed on several dependent variables of the semi-solid mass which can be studied using SSE-P (yield point, yield point time, maximum pressure, pressure at flow cessation, Young Modulus, shear stress at steady flow and apparent/dynamic viscosity), the results of the Multivariate Analysis of Variance showed a significant statistical relationship (p < 0.05) for all tests performed: Wilks' lambda (0.010), Pillai's trace (0.027), and Roy's greatest root (<0.01).…”

Section: Ta and Sse-p Comparisonmentioning

confidence: 99%

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Revolutionizing Three-Dimensional Printing: Enhancing Quality Assurance and Point-of-Care Integration through Instrumentation

Suárez-González,

Díaz-Torres,

Monzón-Rodríguez

et al. 2024

Pharmaceutics

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Three-dimensional printing in the field of additive manufacturing shows potential for customized medicines and solving gaps in paediatric formulations. Despite successful clinical trials, 3D printing use in pharmaceutical point-of-care is limited by regulatory loopholes and a lack of Pharmacopoeia guidelines to ensure quality. Semi-solid extrusion is a 3D printing technology that stands out for its versatility, but understanding the fluid dynamics of the semi-solid mass is critical. The aim of this research is to look into the advantages of instrumenting a 3D printer with a semi-solid extrusion motor-driven printhead, which is able to record the printing pressure over time, for in situ characterization of the semi-solid mass and quality evaluation of dosage forms. Four formulations using hydrochlorothiazide as the active pharmaceutical ingredient and several excipients were used. Their flow properties were studied at different printing speeds and temperatures using traditional techniques (rheometer and Texture Analyzer) and the proposed semi-solid extrusion motor-driven printhead incorporated into a printing platform. In addition, the influence of printing speed in the printing process was also evaluated by the study of printing pressure and printlet quality. The results demonstrated the similarities between the use of a Texture Analyzer and the semi-solid extrusion motor-driven. However, the latter enables temperature selection and printing speed in accordance with the printing process which are critical printing parameters. In addition, due to the incorporation of a sensor, it was possible to conclude, for the first time, that there is a link between changes in essential printing parameters like printing speed or formulations and variations in printing pressure and printlet quality attributes such as the energy require to obtain a single dosage unit, weight or diameter. This breakthrough holds a lot of potential for assuring the quality of 3D printing dosage forms and paving the way for their future incorporation into point-of-care settings.

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Section: Resultsmentioning

confidence: 99%

Section: Ta and Sse-p Comparisonmentioning

confidence: 99%

Revolutionizing Three-Dimensional Printing: Enhancing Quality Assurance and Point-of-Care Integration through Instrumentation

Suárez-González,

Díaz-Torres,

Monzón-Rodríguez

et al. 2024

Pharmaceutics

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Bio‐Based Foams to Function as Future Plastic Substitutes by Biomimicry: Inducing Hydrophobicity with Lignin

Miranda‐Valdez,

Mäkinen,

et al. 2024

Adv Eng Mater

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To replace common plastics, bio‐based alternatives are needed. Cellulose foams, as plant‐based materials, are the most attractive solution, being often biodegradable and inexpensive and having the potential for distributed production. Cellulose and its derivatives, as raw materials, present a fundamental challenge, as they are hydrophilic. Herein, this problem is solved by drawing inspiration from the hydrophobic barrier that lignin creates in wood and applying lignin to methylcellulose (MC) foams. The lignin (0.0–1.0 wt% being the range studied here) is applied directly to the suspension consisting of water and MC (1.8 wt%), which is then foamed and solidified to a dry 3D porous structure. By comparing different types of lignin and the resulting surface morphologies, it is shown that organosolv lignin (OL) most strongly self‐assembles to the air–foam interfaces, achieving area fractions up to 27%. Using different concentrations of OL, how hydrophobicity—described by the initial water contact angle and its time evolution—increases with increasing lignin concentration is then shown. Thus, significantly increased water resistance (up to 91 times higher compared to the pure MC foam), a crucial property for developing novel bio‐based materials that can compete with traditional plastics, is able to be achieved.

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Fractional rheology of colloidal hydrogels with cellulose nanofibers

Miranda-Valdez,

Sourroubille,

Mäkinen

et al. 2024

Cellulose

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Colloidal gels are soft solids composed of particles dispersed in a fluid phase. Their rheological behavior highly depends on the particle concentration, but establishing a relationship can be challenging. This article showcases the potential of fractional rheology to model and predict linear viscoelastic responses of colloidal hydrogels containing TEMPO-oxidized cellulose nanofibers. Cellulose nanofiber hydrogels are soft solids whose rheology is directly related to the particle concentration. Therefore, this work defined the rheological behavior of the hydrogels using a fractional order derivative analytically solved to determine rheological responses in frequency, stress relaxation, and creep. Using two parameters, it evaluated the rheology of cellulose nanofiber hydrogels and established tests that predict rheological behaviors for given particle concentrations. The findings suggested that the fractional approach could become a standard method for characterizing cellulose nanofiber hydrogels in the reported concentration regime. The two parameters of the fractional model build a comparison framework to assess the rheology of different viscoelastic materials. Graphic abstract

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Thermal gelation of cellulose based suspensions

Cited by 3 publications

References 37 publications

Revolutionizing Three-Dimensional Printing: Enhancing Quality Assurance and Point-of-Care Integration through Instrumentation

Revolutionizing Three-Dimensional Printing: Enhancing Quality Assurance and Point-of-Care Integration through Instrumentation

Bio‐Based Foams to Function as Future Plastic Substitutes by Biomimicry: Inducing Hydrophobicity with Lignin

Fractional rheology of colloidal hydrogels with cellulose nanofibers

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