In this study, hydrofoil ribs having NACA 2412 profile were mounted in a novel way at all walls of microchannel heat sink with various configurations to improve its thermo-hydraulic characteristics. The various configurations include comparison between staggered and aligned arrangements, and the variation of rib spacing between two hydrofoils (Sr = 200-600 µm) at a constant cord length (Cr = 400 µm). The performance of various configurations were compared with each other and with smooth channel using parameters like friction factor (f), Nusselt number (Nu), and overall performance is determined by thermal enhancement factor (η). The results showed that the best performance is achieved by the configuration where rib spacing became equal to cord length (Sr = 400 µm). Moreover, staggered configuration performed better than aligned configuration.