Thermal, electrical, and mechanical properties of tween 80/span 80–based organogels and its application in iontophoretic drug delivery

Sagiri, Sai S.; Kumar, Uttam; Champaty, Biswajeet; Singh, Vinay Kumar; Pal, Kunal

doi:10.1002/app.41419

Cited by 7 publications

(4 citation statements)

References 46 publications

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“…The bigels were prepared by fluid‐filled structure mechanism as per our previously reported method with slight modifications . The surfactant mixture of span 80: tween 80 (1 : 2, w/w) was used as the liquid gelator ( S mix ).…”

Section: Methodsmentioning

confidence: 99%

Development of ionic and non‐ionic natural gum‐based bigels: Prospects for drug delivery application

Sahoo

Singh

Uvanesh

et al. 2015

J of Applied Polymer Sci

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Recently, much attention has been focused on the development of gel based formulations for controlled drug delivery applications. Herein, we report the effect of the ionic (gum acacia) and the non-ionic (guar gum) gums on the properties of the bigels prepared with fluid-filled organogels. The microscopic study suggested the presence of flocculated structure in guar gum bigel, whereas, a de-flocculated structure was observed in gum acacia bigel. Infrared spectroscopy suggested the presence of polysaccharides in the bigels. The mechanical properties of the guar gum bigel were better than gum acacia bigel. The conductivity and the release properties suggested superior properties of gum acacia bigel. This indicated that the ionic nature of acacia bigel played a major role in controlled drug delivery, making it a potential bigel for desired pharmaceutical applications.

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Section: Methodsmentioning

confidence: 99%

Development of ionic and non‐ionic natural gum‐based bigels: Prospects for drug delivery application

Sahoo

Singh

Uvanesh

et al. 2015

J of Applied Polymer Sci

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“…On the other hand, a 1.4-fold enhancement in CPDR was recorded for d-AuG0 in the active mode compared to that in the passive mode. Such an increment, although minor, was not an unexpected outcome since nonconducting oleogels have been reported to be slightly responsive toward iontophoretic drug release . However, a striking 3.2-fold increase was observed in the case of d-AuG4 in the active mode compared to that in the passive mode.…”

Section: Discussionmentioning

confidence: 83%

“…Such an increment, although minor, was not an unexpected outcome since nonconducting oleogels have been reported to be slightly responsive toward iontophoretic drug release. 48 However, a striking 3.2-fold increase was observed in the case of d-AuG4 in the active mode compared to that in the passive mode. Clearly, the iontophoretic effect due to the presence of AuNPs was the major responsible factor prevalent in this case.…”

Section: Discussionmentioning

confidence: 93%

Transdermal Delivery of Gold Nanoparticles by a Soybean Oil-Based Oleogel under Iontophoresis

Dhal

Pal

Giri

2020

ACS Appl. Bio Mater.

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Developing a facile mechanism for transporting nanoparticles across the whole skin by overcoming the stratum corneum is a challenging task. Herein, a stimuli-responsive and noninvasive transport of gold nanoparticles (AuNPs) has been reported through the fabrication of AuNP-incorporated soybean oil-based oleogels (AuG) using stearic acid as a gelator. A series of AuG was formulated by incorporating different proportions of AuNPs and a fixed amount of ciprofloxacin hydrochloride (drug) to establish that the composition with the highest concentration of AuNP (d-AuG4) was associated with the best iontophoretic response, validated via the corresponding in vitro drug release under AC field-induced iontophoresis. The sample d-AuG4 exhibited both drug and AuNP permeation across the whole pig ear skin thickness within as early as 1 h under the iontophoresis condition. With relevant control experiments, it was shown that the transport of AuNPs through the stratum corneum tissue and across the whole skin was possible upon the simultaneous fulfillment of two conditions: the presence of a skin permeation enhancer (stearic acid) within the oleogel and iontophoresis. While the literature reported that the permeation time for any free inorganic nanoparticle through the full-skin thickness varied within a few days, the permeation enhancement technique developed here reduced the corresponding delivery time for the AuNPs to a few hours. The extent of AuNP permeation that occurred in the microgram (per cm–2) scale was found to be affected by the duration of iontophoresis, suggesting that AuNPs’ rapid transdermal entry can be simultaneously triggered and modulated by iontophoretic conditions.

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“…Hence, it can be concluded that the addition of GO helped in the formation of a more stable structure in the formulations that had higher levels of GO. Sagiri et al (2015) have mentioned that %SR is the measure of the molecular arrangement of all the constituents that are present in the gel [ 73 ]. Hence, the %SR was calculated to study the percentage decrease in the force values from the maximum to the end of the relaxation time (Equation (5)).…”

Section: Resultsmentioning

confidence: 99%

Graphene Oxide Increases Corneal Permeation of Ciprofloxacin Hydrochloride from Oleogels: A Study with Cocoa Butter-Based Oleogels

Qureshi

Choudhary

Mohanty³

et al. 2020

Gels

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In this work, oleogels of cocoa butter (CB), rice bran oil (RBO), and graphene oxide (GO) were prepared. The prepared oleogels were subjected to various characterization techniques such as bright-field microscopy, X-ray diffraction (XRD), crystallization kinetics, differential scanning calorimetry (DSC), and mechanical studies. The influence of increasing GO content on the in vitro drug release and ex vivo corneal permeation of the model drug (ciprofloxacin HCl—CPH) from the oleogels was also investigated. Bright-field micrographs showed that increment in GO content reduced the size of the globular particles of CB. XRD analysis revealed that CB was crystallized in its β’ and β polymorphic forms in the oleogels, which was in agreement with thermal studies. The mechanical characterization demonstrated that the presence of GO improved the elastic nature and stress-bearing properties of the oleogels. Moreover, GO altered the crystallization kinetics of CB in the oleogels in a composition-dependent manner. The in vitro release of CPH from the oleogels occurred through either Fickian diffusion or fat network relaxation or a combination thereof. Furthermore, the inclusion of GO enhanced the ex vivo permeation of CPH molecules across the caprine cornea. Hence, we concluded that the prepared oleogels could be explored as potential delivery systems for ophthalmic applications.

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Thermal, electrical, and mechanical properties of tween 80/span 80–based organogels and its application in iontophoretic drug delivery

Cited by 7 publications

References 46 publications

Development of ionic and non‐ionic natural gum‐based bigels: Prospects for drug delivery application

Development of ionic and non‐ionic natural gum‐based bigels: Prospects for drug delivery application

Transdermal Delivery of Gold Nanoparticles by a Soybean Oil-Based Oleogel under Iontophoresis

Graphene Oxide Increases Corneal Permeation of Ciprofloxacin Hydrochloride from Oleogels: A Study with Cocoa Butter-Based Oleogels

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