Thermal dysregulation in patients with multiple sclerosis during SARS-CoV-2 infection. The potential therapeutic role of exercise

Razi, Omid; Tartibian, Bakhtyar; Teixeira, Ana Maria; Zamani, Nastaran; Govindasamy, Karuppasamy; Suzuki, Katsuhiko; Laher, Ismail; Zouhal, Hassane

doi:10.1016/j.msard.2022.103557

Cited by 4 publications

(5 citation statements)

References 284 publications

(349 reference statements)

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“…In addition, persons with chronic conditions such as multiple sclerosis are encouraged to exercise to improve their health, despite an impaired ability to remove body heat (13). Higher internal body temperatures in multiple sclerosis patients result from their inability to dilate skin pores and engage in evaporation (14). Their greater heat sensitivity impairs nervous system propagation and undermines their health (13).…”

Section: Prevalence Of Exertional Heat Illnessmentioning

confidence: 99%

Exertional Heat Illness Prevention

Caruso,

King,

Jaggers

2023

ACSM's Health and Fitness Journal

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Section: Prevalence Of Exertional Heat Illnessmentioning

confidence: 99%

Exertional Heat Illness Prevention

Caruso,

King,

Jaggers

2023

ACSM's Health and Fitness Journal

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“…Additionally, alterations in intestinal pathogens and intestinal barrier breakdown can be detected as neuroinflammatory mediators by the gut-brain axis and may exacerbate MS by intensifying autoimmune responses. Fluctuations in the body or ambient temperature and febrile illnesses like COVID-19 can worsen neurological symptoms [ 57 ].…”

Section: Reviewmentioning

confidence: 99%

Exacerbation of Pre-existing Neurological Symptoms With COVID-19 in Patients With Chronic Neurological Diseases: An Updated Systematic Review

Sakibuzzaman¹,

Hassan²,

Hayee³

et al. 2022

Cureus

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The neurotropism of the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) can potentially explain the worsening of symptoms in patients with a history of neurological conditions such as stroke, Parkinson's disease, Alzheimer's, and epilepsy. Several studies have reported that these pre-existing conditions may worsen with a higher frequency of flare-ups, thus resulting in a more significant risk of patient mortality. In this review, we sought to provide an overview of the relationship between pre-existing neurological disorders and COVID-19, focusing on whether the initial infection directly influenced the severity of symptoms. We systematically searched the electronic database PubMed (MEDLINE) and used specific keywords related to our aims from January 2020 to July 2022. All articles published on COVID-19 with keywords pertaining to pre-existing neurological diseases were retrieved and subsequently analyzed. After independent review, the data from 107 articles were selected and evaluated. After analyzing the data from selected articles reviewing the effect of COVID-19 on neurological conditions, we have documented the relationship between said pre-existing neurological diseases, showing an increased risk of hospitalization, admission length, worsening of symptoms, and even mortality in COVID-19 patients.

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“…Viral infection in MS patients is often associated with an increased risk of relapsing ( De Keyser et al, 1998 ). Patients with MS are sensitive to increases in body temperature during exercise sessions ( Razi et al, 2022b ), and a supervised muscle strengthening training program should be modified according to the stage of the disease ( Smith et al, 2006 ; Pedersen and Saltin, 2015 ). Physical exercise is not recommended during any systemic viral disease, since inflammatory reactions in muscle cells and coronary artery walls increase the risk of cardiac sudden death during infection ( Inciardi et al, 2020 ).…”

Section: Practical Considerationsmentioning

confidence: 99%

Multimodal Benefits of Exercise in Patients With Multiple Sclerosis and COVID-19

et al. 2022

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Multiple sclerosis (MS) is a demyelinating disease characterized by plaque formation and neuroinflammation. The plaques can present in various locations, causing a variety of clinical symptoms in patients with MS. Coronavirus disease-2019 (COVID-19) is also associated with systemic inflammation and a cytokine storm which can cause plaque formation in several areas of the brain. These concurring events could exacerbate the disease burden of MS. We review the neuro-invasive properties of SARS-CoV-2 and the possible pathways for the entry of the virus into the central nervous system (CNS). Complications due to this viral infection are similar to those occurring in patients with MS. Conditions related to MS which make patients more susceptible to viral infection include inflammatory status, blood-brain barrier (BBB) permeability, function of CNS cells, and plaque formation. There are also psychoneurological and mood disorders associated with both MS and COVID-19 infections. Finally, we discuss the effects of exercise on peripheral and central inflammation, BBB integrity, glia and neural cells, and remyelination. We conclude that moderate exercise training prior or after infection with SARS-CoV-2 can produce health benefits in patients with MS patients, including reduced mortality and improved physical and mental health of patients with MS.

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Thermal dysregulation in patients with multiple sclerosis during SARS-CoV-2 infection. The potential therapeutic role of exercise

Cited by 4 publications

References 284 publications

Exertional Heat Illness Prevention

Exertional Heat Illness Prevention

Exacerbation of Pre-existing Neurological Symptoms With COVID-19 in Patients With Chronic Neurological Diseases: An Updated Systematic Review

Multimodal Benefits of Exercise in Patients With Multiple Sclerosis and COVID-19

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