Thermal desorption-ion mobility spectrometry: A rapid sensor for the detection of cannabinoids and discrimination of Cannabis sativa L. chemotypes

Contreras, María del Mar; Jurado-Campos, Natividad; Callado, Carolina Sánchez-Carnerero; Arroyo‐Manzanares, Natalia; Fernández, Luis Ángel; Casano, S.; Marco, Santiago; Ferreiro‐Vera, Carlos

doi:10.1016/j.snb.2018.07.031

Cited by 19 publications

(10 citation statements)

References 29 publications

(63 reference statements)

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“…These kinds of results confirmed that the analyzed samples were correctly classified as hemp, since the quantity of Δ8-THC and Δ9-THC was found to be lower than the limits established by the legislation. According to what is indicated in literature [30], in the hemp variety considered (Futura 75), the most present compound was CBDA, followed by CBD; all the other compounds were in very low amounts ranging from 0.01 to 0.06%. CBGA is the compound from which all other cannabinoids are biosynthesized [5], which is probably why it was found at a low concentration in both samples examined.…”

Section: Resultsmentioning

confidence: 82%

Fast Detection of 10 Cannabinoids by RP-HPLC-UV Method in Cannabis sativa L.

Mandrioli

Tura

Scotti³

et al. 2019

Molecules

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Cannabis has regained much attention as a result of updated legislation authorizing many different uses and can be classified on the basis of the content of tetrahydrocannabinol (THC), a psychotropic substance for which there are legal limitations in many countries. For this purpose, accurate qualitative and quantitative determination is essential. The relationship between THC and cannabidiol (CBD) is also significant as the latter substance is endowed with many specific and non-psychoactive proprieties. For these reasons, it becomes increasingly important and urgent to utilize fast, easy, validated, and harmonized procedures for determination of cannabinoids. The procedure described herein allows rapid determination of 10 cannabinoids from the inflorescences of Cannabis sativa L. by extraction with organic solvents. Separation and subsequent detection are by RP-HPLC-UV. Quantification is performed by an external standard method through the construction of calibration curves using pure standard chromatographic reference compounds. The main cannabinoids dosed (g/100 g) in actual samples were cannabidiolic acid (CBDA), CBD, and Δ9-THC (Sample L11 CBDA 0.88 ± 0.04, CBD 0.48 ± 0.02, Δ9-THC 0.06 ± 0.00; Sample L5 CBDA 0.93 ± 0.06, CBD 0.45 ± 0.03, Δ9-THC 0.06 ± 0.00). The present validated RP-HPLC-UV method allows determination of the main cannabinoids in Cannabis sativa L. inflorescences and appropriate legal classification as hemp or drug-type.

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Section: Resultsmentioning

confidence: 82%

Fast Detection of 10 Cannabinoids by RP-HPLC-UV Method in Cannabis sativa L.

Mandrioli

Tura

Scotti³

et al. 2019

Molecules

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“…Concerning IMS, a recent study on cannabinoids, the phenolic components of hemp, enabled their direct analysis in plant solid samples using thermal desorption-IMS. For this, IMS spectra were pre-processed and then, using PCA-linear discriminant analysis, related to their chemotype based on GC-MS [ 166 ]. The reduced mobilities values (K 0 ), which are a characteristic parameter, measured by this technique could be related to specific cannabinoids after comparison with standards, e.g., K 0 values at 1.09 cm 2 V −1 s −1 (cannabidiol/cannabidiolic acid), 1.18 cm 2 V −1 s −1 (cannabidivarin), 1.08 cm 2 V −1 s −1 (Δ 9 -tetrahydrocannabinol/Δ 9 -tetrahydrocannabinolic acid), 1.16 cm 2 V −1 s −1 (Δ 9 -tetrahydrocannabivarin) and 1.05/1.10 cm 2 V −1 s −1 (cannabigerolic acid and/or cannabigerol) ( Figure 9 ).…”

Section: Analytical Tools For the Analysis Of Phenolic Compoundsmentioning

confidence: 99%

“…The arrows show characteristic signals of the chemotypes. “Reprinted from Sensors and Actuators B: Chemical , 273, Contreras et al, Thermal desorption–ion mobility spectrometry: A rapid sensor for the detection of cannabinoids and discrimination of Cannabis sativa L. chemotypes, 1413–1424, Copyright (2018), with permission from Elsevier” [ 166 ].…”

Section: Figurementioning

confidence: 99%

Extraction Systems and Analytical Techniques for Food Phenolic Compounds: A Review

Lama-Muñoz

Contreras

2022

Foods

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Phenolic compounds are highly valuable food components due to their potential utilisation as natural bioactive and antioxidant molecules for the food, cosmetic, chemical, and pharmaceutical industries. For this purpose, the development and optimisation of efficient extraction methods is crucial to obtain phenolic-rich extracts and, for some applications, free of interfering compounds. It should be accompanied with robust analytical tools that enable the standardisation of phenolic-rich extracts for industrial applications. New methodologies based on both novel extraction and/or analysis are also implemented to characterise and elucidate novel chemical structures and to face safety, pharmacology, and toxicity issues related to phenolic compounds at the molecular level. Moreover, in combination with multivariate analysis, the extraction and analysis of phenolic compounds offer tools for plant chemotyping, food traceability and marker selection in omics studies. Therefore, this study reviews extraction techniques applied to recover phenolic compounds from foods and agri-food by-products, including liquid–liquid extraction, solid–liquid extraction assisted by intensification technologies, solid-phase extraction, and combined methods. It also provides an overview of the characterisation techniques, including UV–Vis, infra-red, nuclear magnetic resonance, mass spectrometry and others used in minor applications such as Raman spectroscopy and ion mobility spectrometry, coupled or not to chromatography. Overall, a wide range of methodologies are now available, which can be applied individually and combined to provide complementary results in the roadmap around the study of phenolic compounds.

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“…Ambient pressure drift tube ion mobility spectrometry (IMS) is a rapid gas-phase detection technique, in which a variety of ions are separated by constant collisions with a counter current drift gas driven by a drift electric field. Drift tube ion mobility spectrometry has been widely adopted in the detection of explosives, − narcotics, − toxic industrial compounds, , and chemical warfare agents (CWAs) − owing to its sensitivity, stability, fast response, and high portability. However, according to the chemical composition of the target substance, positive or negative ions or both positive and negative ions may be generated during the ionization process.…”

Section: Introductionmentioning

confidence: 99%

Implementing of Fourier Deconvolution Multiplexing to Fast Polarity Switching Miniaturized Ion Mobility Spectrometer

Yang,

Ye,

et al. 2024

Anal. Chem.

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Ion mobility spectrometry (IMS) is a reliable and sensitive technique for the detection and analysis of compounds at the trace level. Depending on the chemical composition of the sample, compounds may be positively or negatively charged to form different polarity ions and detected in positive or negative polarity of the electric field. In order to detect multiple threats simultaneously with miniaturized devices, using a single detection unit to achieve high resolving power and high sensitivity is important. In this work, a miniaturized drift tube with fast polarity switching capabilities integrated with Fourier deconvolution multiplexing techniques is proposed for the first time as a means to improve the performance of ion mobility spectrometry. The sensitivity and resolving power are improved compared to traditional polarity switching signal averaging data acquisition methods. The displayed device had a high resolving power up to 52 at a drift length of 41 mm and a drift tube voltage of 2 kV. Trinitrotoluene (TNT), methamphetamine (MA), benzene, toluene, methyl tert-butyl ether (MTBE), acetic acid, and methylene chloride were evaluated using the proposed fast polarity switching multiplexing spectrometer and exhibited satisfied performance.

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Thermal desorption-ion mobility spectrometry: A rapid sensor for the detection of cannabinoids and discrimination of Cannabis sativa L. chemotypes

Cited by 19 publications

References 29 publications

Fast Detection of 10 Cannabinoids by RP-HPLC-UV Method in Cannabis sativa L.

Fast Detection of 10 Cannabinoids by RP-HPLC-UV Method in Cannabis sativa L.

Extraction Systems and Analytical Techniques for Food Phenolic Compounds: A Review

Implementing of Fourier Deconvolution Multiplexing to Fast Polarity Switching Miniaturized Ion Mobility Spectrometer

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